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Multifunctionalized Carbon Dots as an Active Nanocarrier for Drug Delivery to the Glioblastoma Cell Line.
Algarra, Manuel; Soto, Juan; Pino-González, Maria Soledad; Gonzalez-Munoz, Elena; Ducic, Tanja.
Afiliação
  • Algarra M; INAMAT-Institute for Advanced Materials and Mathematics, Dept. Science, Public University of Navarra, Campus Arrosadía, 31006 Pamplona, Spain.
  • Soto J; Dept. Physical Chemistry, Faculty of Science, University of Málaga, Avda. Cervantes, 2, 29071 Málaga, Spain.
  • Pino-González MS; Dept. Organic Chemistry, Faculty of Science, University of Málaga, Avda. Cervantes, 2, 29071 Málaga, Spain.
  • Gonzalez-Munoz E; Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND., C/Severo Ochoa, 35, 29590 Málaga, Spain.
  • Ducic T; Dept. Cell Biology, Genetics and Physiology, University of Málaga, 29071 Málaga, Spain.
ACS Omega ; 9(12): 13818-13830, 2024 Mar 26.
Article em En | MEDLINE | ID: mdl-38559983
ABSTRACT
Nanoparticle-based nanocarriers represent a viable alternative to conventional direct administration in cancer cells. This advanced approach employs the use of nanotechnology to transport therapeutic agents directly to cancer cells, thereby reducing the risk of damage to healthy cells and enhancing the efficacy of treatment. By approving nanoparticle-based nanocarriers, the potential for targeted, effective treatment is greatly increased. The so-called carbon-based nanoparticles, or carbon dots, have been hydrothermally prepared and initiated by a polymerization process. We synthesized and characterized nanoparticles of 2-acrylamido-2-methylpropanesulfonic acid, which showed biocompatibility with glioblastoma cells, and further, we tested them as a carrier for the drug riluzole. The obtained nanoparticles have been extensively characterized by techniques to obtain the exact composition of their surface by using Fourier transform infrared (FTIR), X-ray photoelectron spectroscopy (XPS), and nuclear magnetic resonance (NMR) spectroscopy, as well as cryo-transmission electron microscopy. We found that the surface of the synthesized nanoparticles (NPs) is covered mainly by sulfonated, carboxylic, and substituted amide groups. These functional groups make them suitable as carriers for drug delivery in cancer cells. Specifically, we have successfully utilized the NPs as a delivery system for the drug riluzole, which has shown efficacy in treating glioblastoma cancer cells. The effect of nanoparticles as carriers for the riluzole system on glioblastoma cells was studied using live-cell synchrotron-based FTIR microspectroscopy to monitor in situ biochemical changes. After applying nanoparticles as nanocarriers, we have observed changes in all biomacromolecules, including the nucleic acids and protein conformation. These findings provide a strong foundation for further exploration into the development of targeted treatments for glioblastoma.

Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Idioma: En Revista: ACS Omega Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Espanha

Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Idioma: En Revista: ACS Omega Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Espanha