Defining Ultra-Massive Transfusion through a Systematic Review.
Am J Surg
; 228: 192-198, 2024 Feb.
Article
em En
| MEDLINE
| ID: mdl-38616968
ABSTRACT
Background:
Despite the widespread use of ultra-massive transfusion (UMT) as an intervention for trauma patients in hemorrhagic shock, no standard definition exists. We performed a systematic review to determine a consensus definition for UMT.Methods:
A search was performed from 1979-2022. The authors screened studies defining UMT and associated outcomes as defined by our prespecified PICO questions. The PRISMA guidelines were used.Results:
1662 articles met criteria for eligibility assessment, 17 for full-text review and eight for data extraction. Only two studies demonstrated a consensus definition of UMT, which used ≥20 units of red blood cell product within 24hrs. Parameters associated with increased mortality included lower blood pressure, lower pulse and lower Glasgow Coma Score at the time of presentation and a higher injury severity score and undergoing a resuscitative thoracotomy.Conclusions:
The absence of a consensus definition for UMT raises challenges from clinical, research and ethical perspectives. Based on our findings, the authors advocate for the feasibility of standardizing the definition of UMT as ≥20 units of red blood cell product within 24hrs.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Choque Hemorrágico
/
Transfusão de Sangue
Limite:
Humans
Idioma:
En
Revista:
Am J Surg
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Gabão