Spatially fractionated radiation therapy: a critical review on current status of clinical and preclinical studies and knowledge gaps.
Phys Med Biol
; 69(10)2024 May 10.
Article
em En
| MEDLINE
| ID: mdl-38648789
ABSTRACT
Spatially fractionated radiation therapy (SFRT) is a therapeutic approach with the potential to disrupt the classical paradigms of conventional radiation therapy. The high spatial dose modulation in SFRT activates distinct radiobiological mechanisms which lead to a remarkable increase in normal tissue tolerances. Several decades of clinical use and numerous preclinical experiments suggest that SFRT has the potential to increase the therapeutic index, especially in bulky and radioresistant tumors. To unleash the full potential of SFRT a deeper understanding of the underlying biology and its relationship with the complex dosimetry of SFRT is needed. This review provides a critical analysis of the field, discussing not only the main clinical and preclinical findings but also analyzing the main knowledge gaps in a holistic way.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
/
Prevencao_e_fatores_de_risco
/
Agentes_cancerigenos
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Tipos_de_cancer
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Outros_tipos
Base de dados:
MEDLINE
Assunto principal:
Fracionamento da Dose de Radiação
/
Neoplasias
Limite:
Animals
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Humans
Idioma:
En
Revista:
Phys Med Biol
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
França