Prospective study to evaluate radioactive iodine of 20 mCi vs 10-15 mCi in Graves' disease.
BMC Endocr Disord
; 24(1): 54, 2024 Apr 25.
Article
em En
| MEDLINE
| ID: mdl-38664774
ABSTRACT
OBJECTIVES:
To assess whether increasing radioactive iodine dose can increase treatment efficacy in Graves' disease.METHODS:
A prospective study was conducted, including 106 patients receiving 20 mCi (740 MBq) radioactive iodine (RAI), compared with a retrospective data, including 113 patients receiving 10-15 mCi (370-555 MBq) RAI. Remission and failure rates were evaluated at 6 months post-RAI. Statistical analysis was performed using logistic regression and Kaplan-Meier curves.RESULTS:
Patients receiving 20 mCi RAI demonstrated a significantly higher remission rate compared to the 10-15 mCi group (82.1% vs 66.4%, p = 0.009). Median time to remission was shorter in the 20 mCI group (3 vs 4 months, p = 0.002). Hypothyroidism at 6 months was more prevalent in the 20 mCi group (67% vs 53%, p = 0.03). Larger thyroid size (> 60 g) was associated with treatment failure (p = 0.02).CONCLUSIONS:
Higher dosage (20 mCi) RAI showed superior efficacy in achieving remission compared to lower dosages (10-15 mCi) in Graves' disease treatment.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Doença de Graves
/
Radioisótopos do Iodo
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
BMC Endocr Disord
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Tailândia