Honokiol and magnolol: A review of structure-activity relationships of their derivatives.
Phytochemistry
; 223: 114132, 2024 Jul.
Article
em En
| MEDLINE
| ID: mdl-38714288
ABSTRACT
Honokiol (HK) and magnolol (MAG) are typical representatives of neolignans possessing a wide range of biological activities and are employed as traditional medicines in Asia. In the past few decades, HK and MAG have been proven to be promising chemical scaffolds for the development of novel neolignan drugs. This review focuses on recent advances in the medicinal chemistry of HK and MAG derivatives, especially their structure-activity relationships. In addition, it also presents a comprehensive summary of the pharmacology, biosynthetic pathways, and metabolic characteristics of HK and MAG. This review can provide pharmaceutical chemists deeper insights into medicinal research on HK and MAG, and a reference for the rational design of HK and MAG derivatives.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Compostos de Bifenilo
/
Lignanas
Limite:
Humans
Idioma:
En
Revista:
Phytochemistry
Ano de publicação:
2024
Tipo de documento:
Article