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Morphologic Features of Invasion in Lung Adenocarcinoma: Diagnostic Pitfalls.
Thunnissen, Erik; Noguchi, Masayuki; Berezowska, Sabina; Papotti, Mauro Giulio; Filipello, Federica; Minami, Yuko; Blaauwgeers, Hans.
Afiliação
  • Thunnissen E; Department of Pathology, Amsterdam University Medical Center, Location Vumc.
  • Noguchi M; Department of Pathology, Naritatomisato Tokushukai Hospital, Chiba.
  • Berezowska S; Department of Laboratory Medicine and Pathology, Institute of Pathology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
  • Papotti MG; Department of Oncology, University of Turin.
  • Filipello F; Department of Pathology, Michele and Pietro Ferrero Hospital, Verduno (CN) and IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Minami Y; Department of Pathology, National Hospital Organization Ibarakihigashi National Hospital, The Center of Chest Diseases and Severe Motor & Intellectual Disabilities, Tokai, Ibaraki, Japan.
  • Blaauwgeers H; Department of Pathology, OLVG LAB BV, Amsterdam, The Netherlands.
Adv Anat Pathol ; 31(5): 289-302, 2024 Sep 01.
Article em En | MEDLINE | ID: mdl-38736358
ABSTRACT
Reproducibility of pulmonary invasive adenocarcinoma diagnosis is poor when applying the World Health Organization (WHO) classification. In this article, we aimed first to explain by 3-dimensional morphology why simple pattern recognition induces pitfalls for the assessment of invasion as applied in the current WHO classification of pulmonary adenocarcinomas. The underlying iatrogenic-induced morphologic alterations in collapsed adenocarcinoma in situ overlap with criteria for invasive adenocarcinoma. Pitfalls in seemingly acinar and papillary carcinoma are addressed with additional cytokeratin 7 and elastin stains. In addition, we provide more stringent criteria for a better reproducible and likely generalizable classification.
Assuntos

Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Pulmao Base de dados: MEDLINE Assunto principal: Adenocarcinoma / Adenocarcinoma de Pulmão / Neoplasias Pulmonares / Invasividade Neoplásica Limite: Humans Idioma: En Revista: Adv Anat Pathol Assunto da revista: ANATOMIA / PATOLOGIA Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Pulmao Base de dados: MEDLINE Assunto principal: Adenocarcinoma / Adenocarcinoma de Pulmão / Neoplasias Pulmonares / Invasividade Neoplásica Limite: Humans Idioma: En Revista: Adv Anat Pathol Assunto da revista: ANATOMIA / PATOLOGIA Ano de publicação: 2024 Tipo de documento: Article