Glutathionedegrading enzymes in the complex landscape of tumors (Review).
Int J Oncol
; 65(1)2024 07.
Article
em En
| MEDLINE
| ID: mdl-38847236
ABSTRACT
Glutathione (GSH)degrading enzymes are essential for starting the first stages of GSH degradation. These enzymes include extracellular γglutamyl transpeptidase (GGT) and intracellular GSHspecific γglutamylcyclotransferase 1 (ChaC1) and 2. These enzymes are essential for cellular activities, such as immune response, differentiation, proliferation, homeostasis regulation and programmed cell death. Tumor tissue frequently exhibits abnormal expression of GSHdegrading enzymes, which has a key impact on the development and spread of malignancies. The present review summarizes gene and protein structure, catalytic activity and regulation of GSHdegrading enzymes, their vital roles in tumor development (including regulation of oxidative and endoplasmic reticulum stress, control of programmed cell death, promotion of inflammation and tumorigenesis and modulation of drug resistance in tumor cells) and potential role as diagnostic biomarkers and therapeutic targets.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
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Tipos_de_cancer
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Outros_tipos
Base de dados:
MEDLINE
Assunto principal:
Gama-Glutamilciclotransferase
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Gama-Glutamiltransferase
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Glutationa
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Neoplasias
Limite:
Animals
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Humans
Idioma:
En
Revista:
Int J Oncol
Assunto da revista:
NEOPLASIAS
Ano de publicação:
2024
Tipo de documento:
Article