Impact of double-strand breaks induced by uv radiation on neuroinflammation and neurodegenerative disorders.
Mol Biol Rep
; 51(1): 725, 2024 Jun 08.
Article
em En
| MEDLINE
| ID: mdl-38851636
ABSTRACT
Exposure to UV affects the development and growth of a wide range of organisms. Nowadays, researchers are focusing on the impact of UV radiation and its underlying molecular mechanisms, as well as devising strategies to mitigate its harmful effects. Different forms of UV radiation, their typical exposure effects, the impact of UV on DNA integrity, and the deterioration of genetic material are discussed in this review; furthermore, we also review the effects of UV radiation that affect the biological functions of the organisms. Subsequently, we address the processes that aid organisms in navigating the damage in genetic material, neuroinflammation, and neurodegeneration brought on by UV-mediated double-strand breaks. To emphasize the molecular pathways, we conclude the review by going over the animal model studies that highlight the genes and proteins that are impacted by UV radiation.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Temas:
Agentes_cancerigenos
Base de dados:
MEDLINE
Assunto principal:
Raios Ultravioleta
/
Doenças Neurodegenerativas
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Quebras de DNA de Cadeia Dupla
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Doenças Neuroinflamatórias
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Mol Biol Rep
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Índia