Estrogen counteracts age-related decline in beige adipogenesis through the NAMPT-regulated ER stress response.
Nat Aging
; 4(6): 839-853, 2024 Jun.
Article
em En
| MEDLINE
| ID: mdl-38858606
ABSTRACT
Thermogenic beige adipocytes are recognized as potential therapeutic targets for combating metabolic diseases. However, the metabolic advantages that they offer are compromised with aging. Here we show that treating mice with estrogen (E2), a hormone that decreases with age, can counteract the age-related decline in beige adipogenesis when exposed to cold temperature while concurrently enhancing energy expenditure and improving glucose tolerance in mice. Mechanistically, we found that nicotinamide phosphoribosyl transferase (NAMPT) plays a pivotal role in facilitating the formation of E2-induced beige adipocytes, which subsequently suppresses the onset of age-related endoplasmic reticulum (ER) stress. Furthermore, we found that targeting NAMPT signaling, either genetically or pharmacologically, can restore the formation of beige adipocytes by increasing the number of perivascular adipocyte progenitor cells. Conversely, the absence of NAMPT signaling prevents this process. Together, our findings shed light on the mechanisms regulating the age-dependent impairment of beige adipocyte formation and underscore the E2-NAMPT-controlled ER stress pathway as a key regulator of this process.
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Envelhecimento
/
Estrogênios
/
Adipogenia
/
Nicotinamida Fosforribosiltransferase
/
Estresse do Retículo Endoplasmático
/
Adipócitos Bege
Limite:
Animals
Idioma:
En
Revista:
Nat Aging
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Estados Unidos