Patterns of Aneuploidy and Signaling Consequences in Cancer.
Cancer Res
; 2024 Jun 26.
Article
em En
| MEDLINE
| ID: mdl-38924459
ABSTRACT
Aneuploidy, or a change in the number of whole chromosomes or chromosome arms, is a near-universal feature of cancer. Chromosomes affected by aneuploidy are not random, with observed cancer-specific and tissue-specific patterns. Recent advances in genome engineering methods have allowed the creation of models with targeted aneuploidy events. These models can be used to uncover the downstream effects of individual aneuploidies on cancer phenotypes including proliferation, apoptosis, metabolism, and immune signaling. Here, we review the current state of research into the patterns of aneuploidy in cancer and their impact on signaling pathways and biological processes.
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
/
Tipos_de_cancer
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Outros_tipos
Base de dados:
MEDLINE
Idioma:
En
Revista:
Cancer Res
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Estados Unidos