Hyper-late major response after 5â
years of nivolumab: role of treatment beyond progression in head and neck cancer.
Anticancer Drugs
; 2024 Jun 28.
Article
em En
| MEDLINE
| ID: mdl-38941120
ABSTRACT
Patients with recurrent/metastatic (R/M) platinum-refractory squamous cell carcinoma of the head and neck (SCCHN) have fewer treatment options and harbor an especially poor prognosis. Maintaining treatment with anti-PD1 agents beyond response evaluation criteria in solid tumors-defined disease progression (TBP) has been shown to be efficacious in several solid tumors, including head and neck cancer. We present the case of a platinum-refractory locally recurrent, PD-L1-negative hypopharyngeal carcinoma, that received second-line nivolumab which was then maintained beyond progression under the following criteria no Eastern Cooperative Oncology Group performance status deterioration, no rapidly progressive disease, no severe toxicity, and evidence of overall treatment benefit. The patient achieved a partial response 8â
months after starting second-line nivolumab, with progressive disease at 26â
months, then followed by the first TBP with nivolumab lasting for 15â
months due to a new tumor progression. A second TBP with nivolumab lasting for 7â
months, was followed by a third TBP with nivolumab for 12â
months and achieving a major tumor response. Treatment is still ongoing 60â
months after starting nivolumab, with excellent tolerance to therapy. Maintaining anti-PD1 agents beyond progression is an efficacious treatment option for patients with R/M SCCHN, that may achieve very durable disease control and even late major responses.
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01-internacional
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Base de dados:
MEDLINE
Idioma:
En
Revista:
Anticancer Drugs
Assunto da revista:
ANTINEOPLASICOS
Ano de publicação:
2024
Tipo de documento:
Article