The role of signaling lymphocyte activation molecule family receptors in hematologic malignancies.
Curr Opin Oncol
; 36(5): 449-455, 2024 Sep 01.
Article
em En
| MEDLINE
| ID: mdl-39007334
ABSTRACT
PURPOSE OF REVIEW In this review, we provide an overview of the current understanding of SLAM-family receptors in hematologic malignancies. We highlighted their contribution to the disease pathogenesis and targeting strategies to improve therapeutic outcomes. RECENT FINDINGS:
Emerging studies have reported the tumor-promoting role of SLAM-family receptors in various hematologic malignancies, including chronic lymphocytic leukemia, acute myeloid leukemia, and multiple myeloma. Specifically, they regulate the interaction between malignant cells and the tumor microenvironment to promote apoptosis resistance, therapeutic resistance, impairment of antitumor and tumor progression.SUMMARY:
SLAM-family receptors promote the progression of hematologic malignancies by regulating the interaction between malignant cells and the tumor microenvironment. This provides the rationale that SLAM-targeted therapies are appealing strategies to enhance therapeutic outcomes in patients.
Texto completo:
1
Coleções:
01-internacional
Temas:
Cuidados_paliativos
/
Geral
/
Tipos_de_cancer
/
Outros_tipos
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Hematológicas
/
Família de Moléculas de Sinalização da Ativação Linfocitária
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Opin Oncol
/
Curr. opin. oncol
/
Current opinion in oncology
Assunto da revista:
NEOPLASIAS
Ano de publicação:
2024
Tipo de documento:
Article