Comparative study of the effects of antitussive drugs in a canine acute cough model.
Vet Med Sci
; 10(5): e1549, 2024 Sep.
Article
em En
| MEDLINE
| ID: mdl-39041252
ABSTRACT
BACKGROUND:
Cough is a common clinical complaint in small animal practice with limited treatment options for chronic underlying conditions.OBJECTIVES:
The present study aimed to evaluate the efficacy of three antitussive drugs in a novel, minimally invasive canine acute cough model.METHODS:
Five clinically healthy Beagles were used to create an acute cough model by administering sterile saline via a transtracheally placed central venous catheter. Single-dose antitussive effects of butorphanol, maropitant and Danpron were assessed. Cough frequency was measured before and at hourly intervals up to 3 h post-administration of each drug, with a linear mixed model used for statistical analysis.RESULTS:
Butorphanol (0.3 m/kg, IM) significantly reduced cough frequency at 1 and 3 h post-administration. Danpron (0.1 mL/kg, IM) also significantly reduced cough frequency 1 h post-administration; however, this effect was not sustained at 3 h. Maropitant (1 mg/kg, IM) did not significantly reduce cough frequency. The cough induction method was effective and minimally invasive, with no adverse effects.CONCLUSION:
The present study demonstrated that butorphanol has a potent and prolonged antitussive effect in an acute canine cough model, whereas Danpron shows a transient effect. These findings provide valuable insights into the comparative efficacy of commonly used antitussive drugs in dogs.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Antitussígenos
/
Butorfanol
/
Tosse
/
Doenças do Cão
Limite:
Animals
Idioma:
En
Revista:
Vet Med Sci
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Japão