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Clinical characteristics and prognostic clinical factors of anti-gamma-aminobutyric acid-B receptor (GABAB-R) encephalitis in Türkiye: a multicenter study.
Gozubatik-Celik, Rabia Gokcen; Baykan, Betul; Emekli, Ahmed Serkan; Tuzun, Erdem; Soysal, Aysun; Uzunkopru, Cihat; Ilhan Algin, Demet; Comruk, Erol; Sanli, Elif; Akkoyun Arikan, Fatma; Hanagasi, Hasmet; Kürtüncü, Murat; Erturk Cetin, Ozdem; Velioglu, Sibel; Cerrahoglu Sirin, Tuba; Yalaz Tekan, Ulgen; Yayla, Vildan; Cilingir, Vedat; Yilmaz, Vuslat; Basturk Ayhan, Zeliha; Terzi, Murat.
Afiliação
  • Gozubatik-Celik RG; Bakirköy Prof. Dr. Mazhar Osman Training and Research Hospital for Mental Health and Neurological Disorders, Department of Neurology, University of Health Sciences, Istanbul, Türkiye.
  • Baykan B; EMAR Medical Center, Department of Neurology, Istanbul, Türkiye.
  • Emekli AS; Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Türkiye.
  • Tuzun E; Department of Neuroscience, Istanbul University Aziz Sancar Institute of Experimental Medicine (DETAE), Istanbul, Türkiye.
  • Soysal A; Bakirköy Prof. Dr. Mazhar Osman Training and Research Hospital for Mental Health and Neurological Disorders, Department of Neurology, University of Health Sciences, Istanbul, Türkiye.
  • Uzunkopru C; Faculty of Medicine, Department of Neurology, Izmir Katip Çelebi University, Izmir, Türkiye.
  • Ilhan Algin D; Faculty of Medicine, Department of Neurology, Eskisehir Osmangazi University, Eskisehir, Türkiye.
  • Comruk E; Malatya Training and Research Hospital, Department of Neurology, Malatya, Türkiye.
  • Sanli E; Department of Neuroscience, Istanbul University Aziz Sancar Institute of Experimental Medicine (DETAE), Istanbul, Türkiye.
  • Akkoyun Arikan F; Department of Neurology, Kütahya University of Health Sciences, Kütahya, Türkiye.
  • Hanagasi H; Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Türkiye.
  • Kürtüncü M; Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Türkiye.
  • Erturk Cetin O; Sancaktepe Sehit Prof. Dr. Ilhan Varank Training and Research Hospital, University of Health Sciences, Istanbul, Türkiye.
  • Velioglu S; Faculty of Medicine, Department of Neurology, Karadeniz Technical University, Trabzon, Türkiye.
  • Cerrahoglu Sirin T; Sisli Hamidiye Etfal Training and Research Hospital, Department of Neurology, Istanbul, Türkiye.
  • Yalaz Tekan U; Sisli Hamidiye Etfal Training and Research Hospital, Department of Neurology, Istanbul, Türkiye.
  • Yayla V; Sadi Konuk Training and Research Hospital, Department of Neurology, University of Health Sciences, Istanbul, Türkiye.
  • Cilingir V; Faculty of Medicine, Department of Neurology, Van Yüzüncü Yil University, Van, Türkiye.
  • Yilmaz V; Department of Neuroscience, Istanbul University Aziz Sancar Institute of Experimental Medicine (DETAE), Istanbul, Türkiye.
  • Basturk Ayhan Z; Balikesir Atatürk City Hospital, Department of Neurology, Balikesir, Türkiye.
  • Terzi M; Faculty of Medicine, Department of Neurology, Ondokuz Mayis University, Samsun, Türkiye.
Neurol Res ; 47(7): 612-625, 2025 Jul.
Article em En | MEDLINE | ID: mdl-40314255
Male gender and persistent seizures are common features of GABAB-R encephalitis.GABAB-R encephalitis is highly paraneoplastic and is most commonly associated with lung cancer.Notable prognostic factors include psychiatric symptoms, hyponatremia at presentation, drug-resistant seizures, and the presence of malignancy.A subgroup characterized by the presence of only serum GABABR antibodies tends to have a more benign course with limited clinical manifestations and better treatment responsiveness.Patients with both serum and CSF antibody positivity showed trends towards exhibiting higher rates of lung cancer and mortality.
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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Autoanticorpos / Receptores de GABA-B / Encefalite Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Neurol res Ano de publicação: 2025 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Autoanticorpos / Receptores de GABA-B / Encefalite Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Neurol res Ano de publicação: 2025 Tipo de documento: Article