Malabsorption of hydrochlorothiazide following intestinal shunt surgery.
Clin Pharmacokinet
; 4(1): 63-8, 1979.
Article
em En
| MEDLINE
| ID: mdl-421412
ABSTRACT
Hydrochlorothiazide 775mg was administered orally to 5 patients who had undergone intestinal shunt operations for obesity 1.5 to 6 years previously. Postoperative weight loss averaged 53.4kg. The concentrations of hydrochlorothiazide in plasma and urine were determined with gas/liquid chromatography. The mean area under the plasma concentration time curve during 9h in 4 of the patients was 889ng/ml.h. Mean total urinary recovery of hydrochlorothiazide amounted to 23.0mg in the 5 patients, which corresponds to approximately half that seen in healthy volunteers. The gastrointestinal hydrochlorothiazide appears to be substantially reduced after intestinal shunt surgery.
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Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Hidroclorotiazida
/
Absorção Intestinal
/
Intestinos
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Clin Pharmacokinet
Ano de publicação:
1979
Tipo de documento:
Article