Comparative formation of chlorophenol metabolites from hexachlorocyclohexane in mouse and rat in vivo and in vitro.
Carcinogenesis
; 5(11): 1519-21, 1984 Nov.
Article
em En
| MEDLINE
| ID: mdl-6207952
ABSTRACT
Comparative formation of chlorophenol metabolites were evaluated in hexachlorocyclohexane (HCH) fed mouse and rat livers by h.p.l.c. No significant species differences were noted in the formation of chlorophenol metabolites studied both in vivo and in vitro. The results indicate that the marked species difference that is observed in tumor induction between mice and rats by HCH may not be due to the different rate of formation of chlorophenol metabolites.
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Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Hexaclorocicloexano
/
Clorofenóis
Limite:
Animals
Idioma:
En
Revista:
Carcinogenesis
Ano de publicação:
1984
Tipo de documento:
Article