Molecular analysis of alleles segregation at RFLPs within RB-1 gene in four families with hereditary retinoblastoma.
Mater Med Pol
; 26(3): 105-8, 1994.
Article
em En
| MEDLINE
| ID: mdl-7603079
ABSTRACT
Four families with suspected hereditary retinoblastoma in proband and one other family member were examined by genetic segregation analysis of the RB-1 gene loci with specific RFLPs of chromosome 13. Two families, TA-6 and partially CK-46, were informative using this method. In TA-6 family healthy sister (TA-6/10) of the proband was shown not to be a carrier of the mutant RB-1 gene. These results show that the segregation analysis of RB-1 gene loci with specific RFLPs, used as the DNA markers, could be helpful in the genetic diagnosis and counselling in families with hereditary retinoblastoma.
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Coleções:
01-internacional
Temas:
Geral
/
Prevencao_e_fatores_de_risco
/
Hereditariedade
/
Tipos_de_cancer
/
Outros_tipos
Base de dados:
MEDLINE
Assunto principal:
Retinoblastoma
/
Polimorfismo de Fragmento de Restrição
/
Genoma Humano
/
Genes do Retinoblastoma
Limite:
Child, preschool
/
Female
/
Humans
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Infant
/
Male
Idioma:
En
Revista:
Mater Med Pol
Ano de publicação:
1994
Tipo de documento:
Article