Vascular cell adhesion molecule-1: expression in normal and diseased skin and regulation in vivo by interferon gamma.
J Am Acad Dermatol
; 29(1): 67-72, 1993 Jul.
Article
em En
| MEDLINE
| ID: mdl-7686190
ABSTRACT
BACKGROUND:
Vascular cell adhesion molecule-1 (VCAM-1) is an endothelial protein with adhesive properties for inflammatory cells including lymphocytes. Its role in skin disease and regulation in vivo are uncertain.OBJECTIVE:
Our purpose was to determine expression of VCAM-1 in normal and inflamed skin and the effect on this of the T-cell-derived cytokine interferon gamma (IFN-gamma).METHODS:
VCAM-1 was detected immunohistochemically in frozen-section biopsy specimens of inflammatory dermatoses and skin tumors. Volunteers received intradermal IFN-gamma and underwent biopsy 2 hours to 6 days later.RESULTS:
In normal skin, VCAM-1 was present on perivascular dendritic cells and some follicular keratinocytes. In allergic contact dermatitis, atopic dermatitis, and psoriasis, VCAM-1 was variably upregulated on dermal endothelium and dendritic cells, but was most pronounced in lichen planus. IFN-gamma led to marked upregulation of endothelial and dermal dendritic cell VCAM-1.CONCLUSION:
VCAM-1 may be involved in the pathogenesis of various skin diseases and in vivo, IFN-gamma is a potent modulator of its expression.
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Coleções:
01-internacional
Temas:
Geral
/
Tipos_de_cancer
/
Pele
Base de dados:
MEDLINE
Assunto principal:
Pele
/
Dermatopatias
/
Neoplasias Cutâneas
/
Moléculas de Adesão Celular
/
Expressão Gênica
/
Regulação da Expressão Gênica
/
Interferon gama
Limite:
Humans
Idioma:
En
Revista:
J Am Acad Dermatol
Ano de publicação:
1993
Tipo de documento:
Article
País de afiliação:
Reino Unido