Fibrinogen and atherosclerosis.
Wien Klin Wochenschr
; 105(15): 417-24, 1993.
Article
em En
| MEDLINE
| ID: mdl-8379153
ABSTRACT
Fibrin appears to be a multi-potential component of atherogenesis, intervening at virtually all stages of lesion development. Fibrin and microthrombus deposition on normal intima is associated with endothelial disruption and intimal oedema, and oedema is a primary characteristic of early proliferative lesions. Fibrin strands on or in the intima encourage smooth muscle cell (SMC) migration and proliferation, and contribute to the growth of plaques. Fibrin also provides a continuing source of fibrin degradation products (FDP), and these have mitogenic activity which will sustain SMC proliferation in growing plaques, and act as chemoattractants for blood leucocytes. Accumulation of the lipid core in fibrous plaques may also be influenced by fibrin which appears to bind the lipoprotein Lp(a) with high affinity, thereby immobilizing its lipid moiety within the lesion.
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Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Arteriosclerose
/
Fibrinogênio
Limite:
Humans
Idioma:
En
Revista:
Wien Klin Wochenschr
Ano de publicação:
1993
Tipo de documento:
Article
País de afiliação:
Reino Unido