Lack of effect of delta F508 mutation on aerobic capacity in patients with cystic fibrosis.
Clin J Sport Med
; 6(4): 226-31, 1996 Oct.
Article
em En
| MEDLINE
| ID: mdl-8894334
ABSTRACT
OBJECTIVE:
As aerobic exercise capacity, as defined by VO2max, is associated with patient functioning and possibly prognosis in cystic fibrosis (CF), correlations between VO2max phenotype and genotype may be of value.DESIGN:
Retrospective clinical series.SETTING:
Cystic fibrosis referral clinic. PATIENTS Convenience sample of 35 patients with CF consecutively referred for exercise testing. MAIN OUTCOMEMEASURES:
Blood samples were examined for mutations of cystic fibrosis transmembrane regulator (CFTR), Height, wight, pulmonary function, resting-energy expenditure, VO2max, and other exercise variables were assessed in each referred patient.RESULTS:
Statistical comparison of 10 patients who were homozygous for the dF508 mutation of CFTR with 20 patients heterozygous for dF508 revealed no significant differences for height, weight, pulmonary function, resting-energy expenditure, VO2max, or any other exercise variables.CONCLUSIONS:
These results imply a limited effect of the mutation status on overall patient functioning and prognosis. Future identification of more rare CFTR mutations and other genes and subsequent classification of patients in a manner reflective of the cellular physiology may lead to different results.
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Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Consumo de Oxigênio
/
Fenilalanina
/
Regulador de Condutância Transmembrana em Fibrose Cística
/
Fibrose Cística
/
Mutação
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Clin J Sport Med
Assunto da revista:
MEDICINA ESPORTIVA
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Estados Unidos