Down-regulated expression of transforming growth factor beta 1 mRNA in endometrial carcinoma.
Br J Cancer
; 77(8): 1260-6, 1998 Apr.
Article
em En
| MEDLINE
| ID: mdl-9579831
ABSTRACT
Transforming growth factor beta1 (TGF-beta1) is a potent modulator of cell proliferation in vitro, and recent studies have demonstrated its overexpression in several different tumours; nevertheless, the molecular mechanisms of TGF-beta1 action on cell growth and differentiation have not been fully elucidated. To clarify the role of TGF-beta and its receptor in human endometrial proliferation and differentiation, TGF-beta1 expression at both the mRNA and protein levels has been evaluated by using Northern blotting and immunohistochemistry, in both normal (atrophic, proliferative and secretory) and neoplastic (adenocarcinoma) endometrial samples. This study demonstrates that TGF-beta1 mRNA expression is dramatically reduced in endometrial carcinomas with respect to non-neoplastic tissues, whereas the immunohistochemical expression of TGF-beta1 is enhanced in the epithelial component of endometrial carcinomas compared with non-neoplastic tissues. These data suggest that TGF-beta1 acts as a paracrine regulator of endometrial cell proliferation and that it may contribute to the carcinogenic mechanisms of endometrial carcinoma.
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
/
Saude_da_mulher
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Colo_do_utero
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Tipos_de_cancer
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Colo_do_utero
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Outros_tipos
Base de dados:
MEDLINE
Assunto principal:
RNA Mensageiro
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Adenocarcinoma
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Regulação para Baixo
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Fator de Crescimento Transformador beta
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Neoplasias do Endométrio
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Receptores de Ativinas Tipo I
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Proteínas de Neoplasias
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Middle aged
Idioma:
En
Revista:
Br J Cancer
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Itália