Clinical studies of beta-thioguanine deoxyriboside alone and in combination with arabinosyl cytosine.
Med Pediatr Oncol
; 2(2): 199-205, 1976.
Article
em En
| MEDLINE
| ID: mdl-958161
ABSTRACT
Beta-thioguanine deoxyriboside (betaTGdR) is a purine nucleoside derivative which was studied alone or in combination with arabinosyl cytosine (Ara-C) in patients with solid tumors and acute leukemia. No significant responses were observed in 22 patients with solid tumors. The response rate with betaTGdR alone in acute leukemia was 26% and in combination with Ara-C was 24%. Responses were generally of short duration. Toxicity included myelosuppression, nausea, stomatitis, hyperpigmentation, photosensitivity, and liver function abnormalities.
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Coleções:
01-internacional
Temas:
Geral
/
Tipos_de_cancer
/
Leucemia
Base de dados:
MEDLINE
Assunto principal:
Tioguanina
/
Leucemia
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Citarabina
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Desoxirribonucleosídeos
/
Neoplasias
Limite:
Adolescent
/
Adult
/
Aged
/
Child
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Child, preschool
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Med Pediatr Oncol
Ano de publicação:
1976
Tipo de documento:
Article