Evaluating the performance of a genetic test using information from previous studies in place of a gold standard.
Med Care
; 36(8 Suppl): AS46-56, 1998 Aug.
Article
em En
| MEDLINE
| ID: mdl-9708582
ABSTRACT
OBJECTIVES:
To evaluate the performance of a diagnostic test, a researcher usually must classify study subjects with respect to (1) whether the test result was positive or negative and (2) whether the test result should have been positive or negative. To classify the subjects in the second manner, the researcher needs to have access to a gold standard (ie, a test that classifies the subjects with 100% accuracy). The authors show here how to evaluate the performance of a diagnostic test that allows researchers to determine whether a disease that is occurring within a family is attributable to one of two newly discovered genes without the use of a gold standard.METHODS:
By taking advantage of well-known genetic phenomena and their statistical implications, the behavior of the diagnostic test is mathematically modeled, and its performance with respect to various criteria is shown to be functions of genetic parameters.RESULTS:
The performance of the test over a wide range of values of the genetic parameters was evaluated, and cutoff points that would allow the test to perform very well or well with respect to all criteria were found for almost all of the situations examined.CONCLUSIONS:
This test can be used effectively under a wide range of conditions. In addition, because the genetic parameters have been estimated in previous studies, the effectiveness of the test for the specific conditions the researcher may need to run the study under can be evaluated before the study is performed.
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Coleções:
01-internacional
Temas:
Geral
/
Prevencao_e_fatores_de_risco
/
Hereditariedade
Base de dados:
MEDLINE
Assunto principal:
Testes Genéticos
/
Medicina Baseada em Evidências
/
Doenças Genéticas Inatas
Tipo de estudo:
Diagnostic_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
Idioma:
En
Revista:
Med Care
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Estados Unidos