Association of Life-Course Educational Attainment and Breast Cancer Grade in the MEND Study.

Background: Nigeria reports the highest age-standardized mortality rate for breast cancer (BC) among African countries and disproportionately high rates of high-grade cancer. Histological grade is a strong predictor of mortality, and evidence suggests that educational attainment influences cancer outcomes. Objective: We characterize the association between educational trends across the life-course and BC grade at diagnosis. Methods: Data on 224 BC patients enrolled in the Mechanisms for Established and Novel Risk Factors for Breast Cancer in Nigerian Women (MEND) study was analyzed. Participant and parental (mother and father) education was categorized as low (primary school or less) or high (secondary school or greater). Accordingly, the educational trend across the life-course was determined for each participant relative to each parent: stable high, increasing, decreasing, or stable low. BC grade was classified as high (grade 3) or low (grades 1-2). Findings: About 34% of participants, 71% of fathers, and 85% of mothers had low education. Approximately one-third of participants were diagnosed with high-grade BC. Participants with low-grade BC were more likely to have highly educated fathers (p = 0.04). After adjusting for age, comorbidities, marital status and mammogram screening, participants with highly educated fathers were 60% less likely to have high-grade BC (aOR 0.41; 95% CI 0.20 to 0.84) compared to those with less-educated fathers. Stable high life-course education relative to father was also associated with a significantly lower likelihood of having high-grade BC (aOR 0.36; 95% CI 0.15 to 0.87) compared to stable low life-course education. No significant associations were observed for the participant's education, mother's education, or life-course education relative to mother. Conclusions: Early-life socioeconomic status (SES) may influence BC grade. This deserves further study to inform policies that may be useful in reducing high-grade BC in Nigeria.

A comprehensive review of water quality monitoring and assessment in Nigeria.

Nigeria is the most populated black nation in the world with about 199 million people. About 66.3 million Nigerians do not have access to safe drinking water. In this study, research findings on water quality monitoring and assessment in Nigeria over the past two decades were systematically reviewed. There are still grave enforcement issues in Nigeria as quality guidelines are still being contravened at no cost to the infringer due to the corrupt socio-political circumstances of the country. The quality of surface water, groundwater, rainwater and commercially available water was discussed in line with their pollution sources. The quality of surface water was generally poor. Groundwater pollution has come due to landfill leachate, oil and gas exploration and production, sewage and hydrogeological interactions of the groundwater with the base rock. The hydrogeological effect has led to the observation of lead and barium in groundwater in many locations across the country. The main issue with rainwater in Nigeria is the low pH but it was observed to be fairly clean. Commercially available water (bottled or sachet) is currently the best source of drinking water for the Nigerian populace. Bottled water quality is higher than for sachet water and the latter largely influenced by microbe contamination. Future perspectives in water quality monitoring and assessment are suggested in the evaluation of emerging contaminants and micro-pollutants and the utilisation of internet-enabled technologies.