The loss of regeneration competency in the animal kingdom at the expense of immunity: A journey in retrospect.

Regeneration refers to the structural growth of damaged organs or tissues and their functional integration into the existing system. Injury induced regenerative response is extremely variable across the animal kingdom. On one hand the early acoelomates can reform the entire animal even from dissociated cells, on the other; the capacity in humans is mostly restricted to wound healing. A general trend of regenerative ability is the existence of an inverse relationship between the robustness of immune system and the degree of regeneration throughout the animal kingdom. This review summarizes the evolutionary advancement of immune system in different groups and gives an account of their respective regenerative competency.