Assessing the economic burden of multi-causal respiratory diseases in broiler farms in Iran.

The aim of this study was to find the direct economic losses due to the three viral causes of the avian respiratory syndrome, including Newcastle disease (ND), H9N2 influenza, and infectious bronchitis (IB) in stamped-out broiler farms during 2016-2017 across the country. This study was carried out on the information on cross-sectional monitoring in the years 2016-2017. The statistical society of the study was all the active broiler farms of the country stamped out due to respiratory syndrome. This study used compensation insurance data, and other sources. One-way ANOVA or Kruskal-Wallis tests were used to analyze normally and non-normally distributed data. In total, during the study period, 132 broiler farms and 1,723,131 fowls were stamped out. According to the results of the present investigation, the sum of costs and losses due to respiratory complex was 9.47 $US Million, 2016-2017 (5.72 from $US Million chicken meat losses and 3.75 $US Million was the total cost). ND was the main cause of economic losses and costs with 3.86 $US equal to 40.8% of the total. Cost of feeding was the highest followed by veterinary services and medicines, vaccination, and 1-day-old chicks costs with 2.27, 1.11, 0.33, and 0.036 $US Million, 2016-2017. In conclusion, we need to improve the preventive measures against respiratory viruses, especially NDV. Additionally, as the cost of feeding was the largest, it is important to shorten the time interval between disease occurrence and stamping out to reduce the cost.

Use of systemic anti-infective agents in Iran during 1997-1998.

OBJECTIVE: Conduction of standardized national drug utilization review to investigate the pattern of systemic anti-infective agent use in Iran. METHODS: The wholesale data were used. The Anatomical Therapeutic Chemical (ATC) classification and the defined daily dose (DDD) methodology was employed. Data were presented as DDD/1,000 inhabitants"day. Results were compared using national drug statistics of Norway, Sweden, and Denmark. RESULTS: The overall sales of systemic anti-infective agents was 43.5 DDD/1,000 inhabitants/day. The parenteral form of drug accounted for 4.20% and broad-spectrum systemic antibacterial agents accounted for 86.2%. The three most commonly used agents, accounting for 74.1% of total sales, were amoxicillin, co-trimoxazole, and ampicillin. Seven kinds of anti-infective agents (17% of total available agents) accounted for 90% of antibacterial use, with dominance of broad-spectrum agents. Comparison showed differences in pattern and intensity of use. The sales of systemic anti-infective agents in general, particularly antibacterials and anti-tuberclotics, were greater in Iran than in three European countries. Broad-spectrum antibacterial agents accounted for a larger proportion of total sales in Iran. CONCLUSION: The high use of systemic antibacterial agents in general, particularly broad-spectrum agents, suggest the possibility of irrational prescribing, higher prescribed daily doses than DDDs, and a drug wastage. This survey, as a first attempt, provided an overview of anti-infective use in Iran. Thus, it may serve as a basis for further investigative studies and advanced drug policies.

Utilization review of systemic antiinfective agents in a teaching hospital in Tehran, Iran.

OBJECTIVES: To investigate the pattern of systemic antiinfective use in Bouali teaching hospital (BH) within a standardized methodology. METHODS: To perform a standardized and repeatable study, the Anatomic-Therapeutic-Chemical classification and defined daily dose (ATC/DDD) methodology was used for the first time in Iran. The number of systemic antiinfectives (J class) prescribed for inpatients over a period of 6 months was converted to DDDs. DDD per 100 bed-days was used as a quantitative indicator, and the expenditure share of these drugs was computed. Data were compared with those of similar studies in other countries. RESULTS: Total prescription of systemic antiinfectives was 101.92 DDD/100 bed-days, of which 62% related to parenteral forms. 58% to broad-spectrum agents, and 40.2% to broad-spectrum parenteral agents. The five most commonly used drugs were ampicillin, cefazolin, ceftizoxime, gentamicin, and cefalexin. Antiinfectives prescribed for inpatients accounted for 25.2% of total drug sales of the hospital pharmacy. Most prescriptions occurred in infectious diseases ward. followed by the intensive care unit, gynecology, obstetrics, and ear-nose-throat wards. CONCLUSION: Prescribing patterns in different wards, relationships between use and cost. and monthly variations are identified and discussed. High utilization rate and irrational prescription of antiinfectives in BH, along with inadequate hospital and national drug policies may be concluded from this study. Drug utilization research study is a useful tool to highlight patterns of drug use.