RESUMO
Production of hydroxyl anions by tissue samples of pylorus mucous membrane obtained from 45 patients with gastric or duodenal ulcers was investigated. The production was estimated using the recently developed method based on measurement of rate of pH change in urea-containing reaction mixture. The rate of [OH-] generation as a result of H. pylori metabolism accounted on pylorus square varied from 0.4 to 1318.9 mcmol [OH-]/min, and in 90.2% of cases it did not exceed 128.1 mcmol [OH-]/min. This rate is comparable to mean rate of [H+] generation in stomach of healthy man--114.2-238.4 mcmol [H+]/min. Obtained results allow to conclude that this bacterium may participate in regulation of stomach acid-base balance.
Assuntos
Proteínas de Bactérias/metabolismo , Proteínas de Transporte/metabolismo , Infecções por Helicobacter/metabolismo , Helicobacter pylori/enzimologia , Radical Hidroxila/metabolismo , Piloro/microbiologia , Úlcera Gástrica/microbiologia , Proteínas de Bactérias/análise , Biópsia , Proteínas de Transporte/análise , Mucosa Gástrica/metabolismo , Mucosa Gástrica/microbiologia , Mucosa Gástrica/patologia , Humanos , Radical Hidroxila/análise , Piloro/metabolismo , Piloro/patologia , Úlcera Gástrica/metabolismo , Úlcera Gástrica/patologiaRESUMO
AIM: To study of therapeutic activity of local (natamycine) and systemic (fluconasol) antifungal drugs in patients with atopic dermatitis (AD) with mycogenic sensitization and candida carriage. MATERIALS AND METHODS: 29 patients with severe AD and diagnosed contamination of the skin lesions with yeast fungi have received antifungal treatment with fungicidal drugs in low-dose long-term course. RESULTS: The drugs were effective in 83% of patients: poor effect was in 28%, moderate--in 21% and good--in 34% of cases. 5 (17%) patients did not respond. Mild, moderate and severe AD responded in 87, 36 and 60% of patients, respectively. The highest response was registered in patients without sensitization to yeast fungi (78%) or low sensitization (83%). In high sensitization the effect occurred in 57% of the cases. CONCLUSION: The authors have developed indications for treatment with antifungal drugs in AD patients with mycogenic sensitization.