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Environ Toxicol Pharmacol ; 32(1): 75-81, 2011 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-21787733

RESUMO

Asoxime (HI-6) is a well known oxime reactivator used for counteracting intoxication by nerve agents. It is able to reactivate acetylcholinesterase (AChE) inhibited even by sarin or soman. The present experiment was aimed to determine markers of oxidative stress represented by thiobarbituric acid reactive substances and antioxidants represented by ferric reducing antioxidant power, reduced and oxidized glutathione in a Beagle dog model. Two groups of dogs were intramuscularly exposed to single (11.4 mg/kg.b.wt.) or tenfold (114 mg/kg.b.wt.) human therapeutically doses of HI-6. HI-6 affinity for AChE in vitro was evaluated in a separate experiment. Complete serum biochemistry and pharmacokinetics were also performed with significant alteration in blood urea nitrogen, creatine phosphokinase, glucose and triglycerides. Blood samples were collected before HI-6 application and after 30, 60, and 120 min. The overall HI-6 impact on organism is discussed.


Assuntos
Reativadores da Colinesterase/administração & dosagem , Estresse Oxidativo , Oximas/administração & dosagem , Compostos de Piridínio/administração & dosagem , Acetilcolinesterase/metabolismo , Animais , Glicemia/análise , Nitrogênio da Ureia Sanguínea , Reativadores da Colinesterase/sangue , Reativadores da Colinesterase/farmacocinética , Creatina Quinase/sangue , Cães , Glutationa/sangue , Dissulfeto de Glutationa/sangue , Hiperglicemia/sangue , Hiperglicemia/induzido quimicamente , Oximas/sangue , Oximas/farmacocinética , Compostos de Piridínio/sangue , Compostos de Piridínio/farmacocinética , Compostos de Sulfidrila/sangue , Substâncias Reativas com Ácido Tiobarbitúrico/metabolismo , Triglicerídeos/sangue
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