1.
Stroke
; 31(7): 1789-90, 2000 Jul.
Artigo
em Inglês
| MEDLINE
| ID: mdl-10884492
2.
Basic Res Cardiol
; 76(4): 365-8, 1981.
Artigo
em Inglês
| MEDLINE
| ID: mdl-6269527
RESUMO
Two isolated guinea pig hearts (H1, H2) were perfused in series in order to bioassay in the recipient heart (H2) the release of vasoactive metabolites. Due to an effective reoxygenation system transit time between H1 and H2 as only 20 sec. Hypoxic perfusion (30% O2) of H1 caused relaxation of the coronary vessels of H2, and this effect could be completely abolished by adenosine deaminase. Similar results were obtained when H1 was stimulated by isoproterenol while H2 was protected by propranolol. From our findings it is concluded that adenosine is the primary vasodilating substance released by the heart into the coronary circulation.