[Quality management from a legal point of view]. / Qualitätsmanagement aus juristischer Sicht.

The aim of quality management in medicine must be to increase the safety of treatment, to optimize the treatment results, but also to confirm economic justifiability. Participation in multiagency quality assurance measures should create the possibility to assess the quality of the services offered compared with other service providers and to recognize and correct corresponding deficits. Comparative examinations and assessments should serve to improve the quality of the results. The benefits of quality management as an important approach to promoting patient safety should be made known to all stakeholders. Patient-oriented process optimization and patient satisfaction are the focus. Furthermore, quality management should help increase the satisfaction of everyone involved in the process.

[Caregiver intervention studies : Recommendations on endpoints and outcome measures for cognitively impaired care recipients]. / Interventionsstudien zur Unterstützung häuslicher Pflege : Empfehlungen zu Endpunkten und Assessment-Instrumenten bei kognitiv eingeschränkten Pflegebedürftigen.

BACKGROUND: Even though the intervention effects on cognitively impaired care recipients are of interest, the evaluation in dementia caregiver studies on caregiver outcomes is often limited. Furthermore, the comparison of studies and interventions is difficult because of the large variance of endpoints and assessments used in this field. OBJECTIVE: The aim of this study was to give an overview on the most prevalent outcomes for cognitively impaired care recipients and expert based recommendations for assessment. MATERIAL AND METHODS: A written Delphi survey was carried out on 16 assessments from 5 dimensions with 14 experts working in different disciplines in German healthcare and research institutes. RESULTS: The most important outcomes and best rated assessments were 1) for problem behavior: revised memory and behavior problem checklist and neuropsychiatric inventory Q, 2) for depressive symptoms: geriatric depression scale, 3) for quality of life: quality of life in Alzheimer's disease, 4) for cognition: mini mental state examination and 5) for ADL/IADL: Katz activities of daily living and Lawton instrumental activities of daily living. CONCLUSION: Due to the varying experiences of the experts with particular assessments, the ratings were in some cases relatively heterogeneous. Overall previous international recommendations could be confirmed. There is particular need of German validation studies on internationally used instruments within the dimensions of problem behavior and quality of life.

[Ferdinand Eisenberger research stipendium 2015]. / Ferdinand Eisenberger-Forschungsstipendium 2015.

The Ferdinand Eisenberger scholarship program provides interested young urologists with the chance to undertake intensive experimental investigations for a 1-year period outside the clinical routine. Within the framework of a scientific project scholarship holders acquire competence in research and establish important contacts for themselves as well as for their institutions to scientists and research laboratories excelling in basic research. In contrast to scholarships awarded by the large funding institutions, such as the German Research Foundation (Deutsche Forschungsgemeinschaft, DFG) and German Cancer Aid (Deutsche Krebshilfe), the Eisenberger scholarships concentrate on host laboratories in Germany. In this way the German Society of Urology (DGU) hopes to strengthen the research infrastructure of urology in Germany with effective regional and national networks.

[Effectiveness and Cost-Effectiveness of a Multifactorial Fall Prevention Programme in Nursing Homes in a Real-World Setting]. / Effektivität und Kosteneffektivität einer multifaktoriellen Sturzpräventions-maßnahme in Pflegeheimen im Versorgungsalltag.

The purpose of the present study was to analyse the effectiveness and cost-effectiveness of a multifactorial fall prevention programme in nursing home residents in a real-world setting. The adjusted relative risk of a femoral fracture was 0.82 (95% CI 0.72-0.93) in residents exposed to the fall and fracture prevention programme compared to residents from the control group. Given a willingness-to-pay of 50,000 EUR per year free of femoral fractures from a payer perspective the probability that the intervention is cost-effective was 83%.

[Cost of fractures in German hospitals--what role does osteoporosis play?]. / Frakturkosten im deutschen Krankenhaussektor--Welche Rolle spielt die Osteoporose?

OBJECTIVE: The objective of this study was to examine the total and osteoporosis-attributable inpatient costs of 16 fracture types accrued in the German hospital sector in the year 2009. METHODS: To calculate the inpatient fracture costs in the hospital sector we combined data from different official German statistics, i.e., fracture-specific diagnosis data from female and male inpatients in 2009, population data, fracture-specific diagnosis-related groups (DRGs), and per diem capital costs in hospitals. The share of fractures which were attributable to osteoporosis had been estimated by the epidemiological concept of "population attributable risk". Calculation of these risks was based on empirical data obtained from the national and international literature. RESULTS: For the year 2009 the total inpatient costs accrued by the 16 fracture types considered in our analyses amounted to 2.4 billion Euros. Of these, 860 million Euros (36%) were attributable to osteoporosis. The main cost drivers were hip fractures. CONCLUSION: Fractures accrue relevant hospital costs in Germany. In order to use the limited resources of the German health-care system in an efficient way, future measures to reduce the number of incident fractures should be designed and evaluated in terms of cost-effectiveness.

CT perfusion technique for assessment of early kidney allograft dysfunction: preliminary results.

OBJECTIVES: To assess the benefit of quantitative computed tomography (CT) perfusion for differentiating acute tubular necrosis (ATN) and acute rejection (AR) in kidney allografts. METHODS: Twenty-two patients with acute kidney allograft dysfunction caused by either AR (n = 6) or ATN (n = 16) were retrospectively included in the study. All patients initially underwent a multiphase CT angiography (CTA) protocol (12 phases, one phase every 3.5 s) covering the whole graft to exclude acute postoperative complications. Multiphase CT dataset and dedicated software were used to calculate renal blood flow. Renal biopsy or clinical course of disease served as the standard of reference. Mean effective radiation dose and mean amount of contrast media were calculated. RESULTS: Renal blood flow values were significantly lower (P = 0.001) in allografts undergoing AR (48.3 ± 21 ml/100 ml/min) compared with those with ATN (77.5 ± 21 ml/100 ml/min). No significant difference (P = 0.71) was observed regarding creatinine level with 5.65 ± 3.1 mg/dl in AR and 5.3 ± 1.9 mg/dl in ATN. The mean effective radiation dose of the CT perfusion protocol was 13.6 ± 5.2 mSv; the mean amount of contrast media applied was 34.5 ± 5.1 ml. All examinations were performed without complications. CONCLUSION: CT perfusion of kidney allografts may help to differentiate between ATN and rejection. KEY POINTS: • Quantitative CT perfusion of renal transplants is feasible. • CT perfusion could help to non-invasively differentiate AR from ATN. • CT perfusion might make some renal biopsies unnecessary.

Cost-effectiveness of a multifactorial fall prevention program in nursing homes.

UNLABELLED: The purpose of this study was to analyze the cost-effectiveness of a multifactorial fall prevention program in nursing home residents. Given a willingness-to-pay (WTP) of 50,000 EUR per year free of femoral fracture, the probability that the intervention is cost-effective is 83%. INTRODUCTION: Despite their increased risk of falls and fractures, nursing home residents have been neglected in economic evaluations of fall prevention programs so far. The purpose of this study was to analyze, for the first time, the cost-effectiveness of a multifactorial fall prevention program in nursing home residents. METHODS: This study is part of a prospective, unblinded, cluster, nonrandomized, controlled study focusing on the transfer of an efficacious fall prevention program into a real-world setting. The analyzed subsample was derived from claims data and consisted of data on intervention (n=256, residents n=10,178) and control homes (n=893, residents n=22,974), representing all insurants of a sickness fund (AOK Bavaria, Germany) who were 65 years or older, residing in a nursing home on the 31st of March 2007 and had a level of care of ≥1 according to the classification of the statutory long-term care insurance. Time free of femoral fracture (ICD-10, S72) was used as measure of health effects. Femoral fracture-related costs and intervention costs were measured from a payer perspective. Multivariate regression models were applied. Sensitivity analyses were performed and cost-effectiveness acceptability curves computed. RESULTS: Within the first year of the intervention, femoral fracture rate was significantly reduced, resulting in a nonsignificant incremental mean time of 1.41 days free of femoral fracture. Incremental mean total direct costs were 29 EUR per resident, which was not significant. The incremental cost-effectiveness ratio (ICER) was 7,481 EUR per year free of femoral fracture. The probability of an ICER<50,000 EUR per year free of femoral fracture was 83%. CONCLUSION: Depending on the amount the decision-maker is willing to pay for the incremental effect, the fall prevention program might be cost-effective within the first year. Future studies should expand the range of costs and effects measured.

Assessment of adaptive walking performance.

Although mostly negative aspects are reported to be associated with gait variability, irregular walking is needed when walking performance has to be adapted to specific environmental conditions. The aim of this study was to evaluate the test-retest reliability and discriminative ability of a measure to assess adaptive walking performance and to identify parameters associated with test performance in young and elderly subjects. Eighteen older (mean age 78.1 years) and 19 young women (mean age 30.8 years) were instructed to walk as precisely as possible over a defined course targeting 26 arbitrarily positioned rectangle boxes fixed on an instrumented walk way with embedded pressure sensors. ICC(1,1) of 0.79 demonstrated sufficient reliability in the cohort of older women. Targeting was significantly worse (or deviation was larger) in older women than in young women (mean 3.20cm versus 2.27cm, p=0.005). Mean gait speed of the older women was higher during the test (0.50m/s versus 0.40m/s, p=0.020), but not during unconstrained walking (1.15m/s versus 1.50m/s, p<0.001). The deviation measure classified 78% of the subjects into correct age group (sensitivity 67%, specificity 90%, p=0.003). Adaptive walking performance was associated with parameters describing physical performance as well as with cognitive executive function. This study shows that this test of adaptive walking performance is a reliable measure of irregular walking with ability to discriminate between young and older subjects. Our results suggest that older persons might try to camouflage their lack of accuracy during adaptive walking by higher gait speed.