[Spatial accessibility to animal health care - a GIS based analysis]. / Räumliche Zugänglichkeit zu tiermedizinischer Versorgung ­ eine GIS-basierte Analyse.

INTRODUCTION: Various studies from the past years examine the changing conditions and challenges in the veterinary sector. Secured access to public and private care services is a prerequisite for a holistically oriented health care system ("One Health"). In the present study, a multidimensional concept of accessibility to care services was used for the first time to determine and visualize the density of the animal health care system in Switzerland. Traditional indicators used to describe care structures focus either on availability or accessibility. In order to overcome the limitations of traditional indicators, the family of methods known as Floating-Catchment-Area-Methods (FCA) has been developed in care geographical research. The strength of FCA methods lies in the fact that they output accessibility independent of administrative boundaries and at the same time consider the spatial distance and available capacities. The study provides insight into the density of animal health care services using FCA methods and geographical information systems (GIS). Data on providers of veterinary services in the companion animal sector and, on the demand side, data on dogs and cats kept in Switzerland served as illustrative example. The result was interactive maps of the density of health care and the structure of spatial accessibility to veterinary providers and consumers. As expected, high spatial accessibility is found in the urban centers and the agglomerations of the Central Plateau. In contrast, spatial accessibility to medical services for dogs and cats is often lower in peripheral areas. Due to hitherto unavailable data, various analyses had to be postponed for the time being. For example, the model could of course be extended to all animal species and all types of medical services. In addition, it would also be possible to forecast the future density of health care, or to optimize the care system. Together with the relevant industry stakeholders, these gaps could be closed, and the model and the resulting findings could be further differentiated. The results should serve private actors in the concerned value chains, but also decision-makers in the public veterinary service, governmental authorities, agricultural bodies, universities, etc. as a basis for strategic decisions regarding the issue of medical supply density and care services in the animal sector.

INTRODUCTION: Ces dernières années, divers travaux ont examiné l'évolution des conditions cadres et des défis dans le secteur vétérinaire. L'assurance d'un accès aux soins publics et privés est une condition préalable à un système de santé holistique (« One Health ¼). Dans le travail présent, on a tenté pour la première fois d'enregistrer et de visualiser la densité d'approvisionnement du système de soins vétérinaires en Suisse en utilisant un concept multidimensionnel d'accessibilité aux offres de soins. Les indicateurs traditionnels pour décrire les structures de soins se concentrent soit sur la disponibilité soit sur l'accessibilité. Afin de contrer les limites des indicateurs traditionnels, la famille de méthodes du Floating-Catchment-Area (FCA) s'est développée dans la recherche en géographie sanitaire. La force des méthodes FCA est qu'elles fournissent un accès indépendamment des limites administratives, tout en tenant compte de la distance spatiale et de la capacité disponible. Ce travail permet d'avoir un aperçu de la densité de l'offre vétérinaire en utilisant la méthodologie FCA en tenant compte de systèmes d'information géographique (SIG). Les données sur les prestataires de services vétérinaires dans le secteur des animaux de compagnie et sur la demande concernant les chiens et les chats vivant en Suisse ont servi d'exemple. Le résultat a été des cartes interactives de la densité de l'offre et de la structure de l'accessibilité spatiale aux prestataires vétérinaires et de celle des consommateurs. Comme prévu, il existe un degré élevé d'accessibilité spatiale dans les centres urbains et les agglomérations du plateau suisse. En revanche, l'accessibilité spatiale aux services vétérinaires pour chiens et chats est souvent plus basse dans les zones périphériques. En raison de données indisponibles précédemment, diverses analyses ont dû être abandonnées dans un premier temps. Ce modèle pourrait être étendu à toutes les espèces animales et aux diverses offres vétérinaires. En outre, il serait également possible de faire des prévisions sur la future densité de l'offre ou sur son optimisation. Conjointement avec les acteurs de la branche concernés, ces lacunes pourraient être comblées avec certitude et le modèle et les résultats qui en résulteraient seraient encore plus différenciés. Les résultats sont destinés à aider les acteurs privés dans les chaînes de valeur ajoutée, mais ils pourraient aussi servir de base aux décideurs des services vétérinaires publics, aux autorités d'exécution, aux organes de l'agriculture, aux universités, etc., pour prendre des décisions stratégiques autour du thème de la densité de l'offre médicale dans le secteur animal.

[Long-term treatment of patients with symptomatic gastroesophageal reflux disease comparing costs and efficacy over 6 months of treatment with Nexium On-Demand Treatment or Nexium continuous treatment. An open, randomised multi-center study]. / Wirksamkeit und Kosten einer kontinuierlichen Langzeit- behandlung mit Esomeprazol versus einer Anwendung bei Bedarf bei symptomatischen Reflux-Patienten in der Praxis ohne endoskopische Abklärung-die ONE Studie (On-demand Nexium Evaluation).

This open, randomized study (ONE: On-demand Nexium Evaluation) compared the two long-term management options with esomeprazole 20 mg--continuous daily or on-demand treatment--in endoscopically uninvestigated patients seeking primary care for symptoms suggestive of gastroesophageal reflux disease (GERD) who demonstrated complete relief of symptoms after four weeks of initial treatment with esomeprazole 40 mg. In total 1904 patients were randomized. During 26 weeks 913 patients received continuous daily therapy with esomeprazole 20 mg, once daily, while 991 patients were treated with esomeprazole 20 mg on-demand. The continuous therapy offered slightly better relief of the symptom heartburn, however esomeprazole 20 mg taken on-demand was associated with lower direct medical costs. Esomeprazole was generally well tolerated.

Hospital health care resource utilization and costs of colorectal cancer during the first 3-year period following diagnosis in Switzerland.

BACKGROUND: In industrialized countries, colorectal cancer is a leading cause of morbidity and mortality. Decisions on colorectal cancer screening are based on cost-effectiveness analyses that rely on colorectal cancer cost studies. Additionally, the study of the resource utilization pattern may lead to cost-saving strategies in the care of colorectal cancer. AIM: To estimate hospital resource utilization, the use of various therapy modalities and costs of colorectal cancer cases undergoing surgery during the first 3 years following the diagnosis at a Swiss university hospital. METHODS: Consecutive colorectal cancer patients from 1997 to 1998 were identified using the surgery database of the University Hospital of Basel and followed for a period of 3 years. In-hospital resource utilization and costs were retrieved from the computerized administrative records. Treatment outside of the hospital during the study period constituted an exclusion criterion. RESULTS: Eighty-three (94%) of 89 patients undergoing surgery for colorectal cancer were included in the study, 58 with colon cancer and 25 with rectal cancer. The average ages were 70.3 and 63.6 years, respectively. Overall, 59% of the patients were treated with surgery alone, 27% also had chemotherapy and 15% received additional chemoradiotherapy. These percentages and resource utilization varied broadly between the two colorectal cancer groups. On average, patients were admitted to the hospital 2.7 times and the hospital length of stay amounted to 35 days. They were visited by doctors 69 times, and examined with colonoscopy, ultrasonography and computerized tomography 2.7, 3.2 and 2.4 times, respectively. Mean costs incurred for rectal cancer (US dollars 40,230) were about 22% higher than for colon cancer patients (US dollars 33,079). Hospitalization and surgical therapy generated the greatest costs. Expenses were highest for the first year and with more severe disease stages at diagnosis. CONCLUSIONS: Colorectal cancer is an expensive disease. Economic analyses on screening should take into account the large resource utilization and cost variability by performing sensitivity analysis on broad cost ranges. Furthermore, they should consider stage shifting at diagnosis and include stage-specific costs.

[Assessment of gastric emptying]. / Messung der Magenentleerung.

In the absence of overt mucosal lesions, abnormalities of gastroduodenal motorfunction are considered to be important in the pathogenesis of many upper abdominal symptoms. These may be idiopathic, occur following gastric surgery, or in association with diseases such as diabetes mellitus. A variety of investigations have been developed to examine the motility of the stomach and duodenum. To date the most reliable and useful techniques are those which assess gastric transit either radiologically or scintigraphically. Assessment of the expulsion of radio-opaque gastric markers with a single abdominal x-ray can be performed as a simple outpatient screening procedure. More precise radioisotopic definition of delayed gastric emptying, however, requires access to a Nuclear Medicine Department. A number of other approaches are currently under investigation as potential diagnostic tests. The future role of these techniques is unclear, although 13C breath testing may soon permit rapid and simple screening of gastric emptying abnormalities without exposure to ionizing radiation. At present, other techniques such as ultrasound, antropyloroduodenal manometry, and magnetic resonance imaging have application only in research centers.

Non-invasive assessment of gastrointestinal motility disorders in diabetic patients with and without cardiovascular signs of autonomic neuropathy.

Twenty six patients with insulin dependent diabetes mellitus underwent a gastric emptying test, a gall bladder contraction test, an orocaecal transit study, and a colon transit test. Eleven patients had signs of cardiovascular autonomic neuropathy, 15 patients were without signs of cardiovascular autonomic neuropathy. Mean gastric clearance of radioopaque markers ingested with a meal averaged 29.5 (2.3) markers per six hours in subjects without cardiovascular autonomic neuropathy compared with 17.8 (2.3) markers per six hours in patients with cardiovascular autonomic neuropathy (p < 0.02). Gall bladder emptying in response to graded CCK8 stimulation was impaired in five of 11 patients with cardiovascular autonomic neuropathy, whereas it was normal in the patients without cardiovascular autonomic neuropathy (p < 0.01). Oral caecal transit times were not significantly different in the two patient groups, whereas colonic transit was slower in the patients with cardiovascular autonomic neuropathy compared with the group without cardiovascular autonomic neuropathy (p < 0.02). There was no correlation between disturbed gastric clearance, impaired gall bladder contraction, and prolonged colonic transit time in the patients with cardiovascular autonomic neuropathy nor was there a correlation between any disturbed motor function and age or duration of diabetes. It is concluded that autonomic neuropathy can affect motor functions throughout the gastro-intestinal tract. Any disturbed motor function in the gut could therefore be one of the numerous expressions of diabetic neuropathy affecting the cardiovascular, the endocrine or the gastrointestinal system.