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1.
J Med Educ Curric Dev ; 10: 23821205231213716, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-38025024

RESUMO

OBJECTIVES: The Royal College of Surgeons (RCS) Diversity Review 2021 found that premedical school students from ethnic minority backgrounds were dissuaded from pursuing a surgical career. Gloucestershire is in the bottom 20% of disadvantaged counties; there is no widening participation (WP) scheme in the county. We implemented a fully inclusive WP scheme in Gloucester, with means of accessing virtual and face-to-face work experience, to enhance the equity of work experience. METHODS: A three-stage project was conducted. Stage 1; two separate virtual Q and A sessions, to allow students to ask questions about life as a doctor. Stage 2; conversation between student and patient held virtually, to gain insight into working as a doctor to help determine whether medicine is the career for them. Stage 3; face-to-face work experience. Distribution sent to all 58 schools (state and private) in the county, targeted at secondary school children. RESULTS: One hundred twenty-nine people attended the Q and A; 70 feedback responses received. Of the total, 86% female and 56% of ethnic minority background. 26% did not have an immediate family member that attended university, 10% had care-giving responsibilities. Eighty-one percent rated the session >8/10 for usefulness. Twenty-seven undertook the virtual conversation, feedback from 11; 91% female, 45% of ethnic minority background, and 27% did not have an immediate family member that attended university. All rated the session 10/10 for usefulness. 10 attended the face-to-face experience, 50% from an ethnic minority background. CONCLUSION: The RCS Report identified barriers to aspiring students from less-privileged backgrounds pursuing a medical career. More needs to be done with WP schemes to promote equity. Targeted distribution of WP schemes to all schools, utilization of a variety of means of offering work experience, and accessibility to any school-aged student were aspects of our WP to improve exposure to the medical profession.

2.
Contemp Nurse ; 56(4): 297-308, 2020 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-32799620

RESUMO

Nurses and midwives of Australia now is the time for change! As powerfully placed, Indigenous and non-Indigenous nursing and midwifery professionals, together we can ensure an effective and robust Indigenous curriculum in our nursing and midwifery schools of education. Today, Australia finds itself in a shifting tide of social change, where the voices for better and safer health care ring out loud. Voices for justice, equity and equality reverberate across our cities, our streets, homes, and institutions of learning. It is a call for new songlines of reform. The need to embed meaningful Indigenous health curricula is stronger now than it ever was for Australian nursing and midwifery. It is essential that nursing and midwifery leadership continue to build an authentic collaborative environment for Indigenous curriculum development. Bipartisan alliance is imperative for all academic staff to be confident in their teaching and learning experiences with Indigenous health syllabus. This paper is a call out. Now is the time for Indigenous and non-Indigenous nurses and midwives to make a stand together, for justice and equity in our teaching, learning, and practice. Together we will dismantle systems, policy, and practices in health that oppress. The Black Lives Matter movement provides us with a 'now window' of accepted dialogue to build a better, culturally safe Australian nursing and midwifery workforce, ensuring that Black Lives Matter in all aspects of health care.


Assuntos
Pessoal Administrativo/psicologia , Negro ou Afro-Americano/psicologia , Assistência à Saúde Culturalmente Competente/organização & administração , Tocologia/educação , Cuidados de Enfermagem/psicologia , Recursos Humanos de Enfermagem Hospitalar/psicologia , Racismo/prevenção & controle , Estudantes de Enfermagem/psicologia , Adulto , Austrália , Currículo , Bacharelado em Enfermagem , Feminino , Humanos , Liderança , Masculino , Pessoa de Meia-Idade , Recursos Humanos de Enfermagem Hospitalar/educação , Gravidez , Racismo/psicologia
3.
Phys Med Biol ; 61(16): 5993-6010, 2016 08 21.
Artigo em Inglês | MEDLINE | ID: mdl-27435339

RESUMO

Gold nanoparticles (GNPs) have shown potential as dose enhancers for radiation therapy. Since damage to the genome affects the viability of a cell, it is generally assumed that GNPs have to localise within the cell nucleus. In practice, however, GNPs tend to localise in the cytoplasm yet still appear to have a dose enhancing effect on the cell. Whether this effect can be attributed to stress-induced biological mechanisms or to physical damage to extra-nuclear cellular targets is still unclear. There is however growing evidence to suggest that the cellular response to radiation can also be influenced by indirect processes induced when the nucleus is not directly targeted by radiation. The mitochondrion in particular may be an effective extra-nuclear radiation target given its many important functional roles in the cell. To more accurately predict the physical effect of radiation within different cell organelles, we measured the full chemical composition of a whole human lymphocytic JURKAT cell as well as two separate organelles; the cell nucleus and the mitochondrion. The experimental measurements found that all three biological materials had similar ionisation energies ∼70 eV, substantially lower than that of liquid water ∼78 eV. Monte Carlo simulations for 10-50 keV incident photons showed higher energy deposition and ionisation numbers in the cell and organelle materials compared to liquid water. Adding a 1% mass fraction of gold to each material increased the energy deposition by a factor of ∼1.8 when averaged over all incident photon energies. Simulations of a realistic compartmentalised cell show that the presence of gold in the cytosol increases the energy deposition in the mitochondrial volume more than within the nuclear volume. We find this is due to sub-micron delocalisation of energy by photoelectrons, making the mitochondria a potentially viable indirect radiation target for GNPs that localise to the cytosol.


Assuntos
Núcleo Celular/efeitos da radiação , Citosol/efeitos da radiação , Ouro/química , Nanopartículas Metálicas/química , Mitocôndrias/efeitos da radiação , Fótons , Humanos , Células Jurkat , Método de Monte Carlo , Doses de Radiação
4.
Pharmacol Biochem Behav ; 103(3): 481-6, 2013 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-23046851

RESUMO

Methamphetamine use disorders are a persistent public health concern. Behavioral treatments have demonstrated that providing access to non-drug alternative reinforcers reduces methamphetamine use. The purpose of this human laboratory experiment was to determine how changes in response cost for non-drug alternative reinforcers influenced methamphetamine choice. Seven subjects with past year histories of recreational stimulant use completed a placebo-controlled, crossover, double-blind protocol in which they first sampled doses of oral methamphetamine (0, 8 or 16 mg) and completed a battery of subject-rated and physiological measures. During subsequent sessions, subjects then made eight discrete choices between 1/8th of the sampled dose and an alternative reinforcer ($0.25). The response cost to earn a methamphetamine dose was always 500 responses (FR500). The response cost for the alternative reinforcer varied across sessions (FR500, FR1000, FR2000, FR3000). Methamphetamine functioned as a positive reinforcer and produced prototypical stimulant-like effects (e.g., elevated blood pressure, increased ratings of Stimulated). Choice for doses over money was sensitive to changes in response cost for alternative reinforcers in that more doses were taken at higher FR values than at lower FR values. Placebo choices changed as a function of alternative reinforcer response cost to a greater degree than active methamphetamine choices. These findings suggest that manipulating the effort necessary to earn alternative reinforcers could impact methamphetamine use.


Assuntos
Comportamento de Escolha/efeitos dos fármacos , Metanfetamina/farmacologia , Reforço Psicológico , Administração Oral , Adulto , Pressão Sanguínea/efeitos dos fármacos , Estimulantes do Sistema Nervoso Central/farmacologia , Estudos Cross-Over , Método Duplo-Cego , Feminino , Frequência Cardíaca/efeitos dos fármacos , Humanos , Masculino , Metanfetamina/administração & dosagem , Esquema de Reforço , Autoadministração , Autorrelato
5.
Trop Med Int Health ; 17(2): 147-52, 2012 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-22032415

RESUMO

OBJECTIVES: This enquiry aimed to provide a snap-shot of availability, price and quality of malaria rapid diagnostic tests (RDTs) in private health facilities at selected sites in six malaria-endemic countries in Africa, South East Asia and South America. METHODS: In each study site, data collectors surveyed private healthcare facilities which were selected based on accessibility from their home institution. Using a questionnaire, information was recorded about the facility itself and the malaria RDT(s) available. Where possible, a small number of RDTs were procured and quality control tested using a standardized procedure. RESULTS: Of the 324 private healthcare facilities visited, 35 outlets (mainly private clinics and hospitals) were found to supply 10 different types of RDTs products. RDT prices across the six countries ranged from US$1.00 to $16.81. Five of the 14 malaria RDTs collected failed quality control testing. CONCLUSIONS: In the private outlets sampled, the availability of RDTs was limited. Some of the RDTs whose quality we tested demonstrated inadequate sensitivity. This presents a number of risks. Given the more widespread distribution of antimalarials currently planned for private sector facilities, parasite-based diagnosis in this sector will be essential to adhere to the WHO guidelines for effective case management of malaria. Considerable regulation and quality control are also necessary to assure the availability of accurate and reliable RDTs, as well as adequate case management and provider adherence to RDT results. Public sector engagement is likely to be essential in this process.


Assuntos
Comércio , Testes Diagnósticos de Rotina , Acessibilidade aos Serviços de Saúde , Serviços de Saúde , Malária/diagnóstico , Setor Privado , África , Instituições de Assistência Ambulatorial , Sudeste Asiático , Testes Diagnósticos de Rotina/economia , Testes Diagnósticos de Rotina/normas , Doenças Endêmicas , Pesquisas sobre Atenção à Saúde , Serviços de Saúde/economia , Serviços de Saúde/normas , Hospitais , Humanos , Malária/economia , Malária/parasitologia , Plasmodium falciparum , Plasmodium vivax , Setor Privado/economia , Setor Privado/normas , Controle de Qualidade , América do Sul , Inquéritos e Questionários
6.
Postgrad Med J ; 86(1012): 106-15, 2010 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-20145060

RESUMO

Staging for non-small cell lung cancer (NSCLC) requires accurate assessment of the mediastinal lymph nodes which determines treatment and outcome. As radiological staging is limited by its specificity and sensitivity, it is necessary to sample the mediastinal nodes. Traditionally, mediastinoscopy has been used for evaluation of the mediastinum especially when radical treatment is contemplated, although conventional transbronchial needle aspiration (TBNA) has also been used in other situations for staging and diagnostic purposes. Endobronchial ultrasound guided transbronchial needle aspiration (EBUS-TBNA) offers a minimally invasive alternative to mediastinoscopy with additional access to the hilar nodes, a better safety profile, and it removes the costs and hazards of theatre time and general anaesthesia with comparable sensitivity, although the negative predictive value of mediastinoscopy (and sample size) is greater. EBUS-TBNA also obtains larger samples than conventional TBNA, has superior performance and theoretically is safer, allowing real-time sampling under direct vision. It can also have predictive value both in sonographic appearance of the nodes and histological characteristics. EBUS-TBNA is therefore indicated for NSCLC staging, diagnosis of lung cancer when there is no endobronchial lesion, and diagnosis of both benign (especially tuberculosis and sarcoidosis) and malignant mediastinal lesions. The procedure is different than for flexible bronchoscopy, takes longer, and requires more training. EBUS-TBNA is more expensive than conventional TBNA but can save costs by reducing the number of more costly mediastinoscopies. Revenue based tariff systems have been slow to reflect the innovation of techniques such as EBUS-TBNA. In the future, endobronchial ultrasound may have applications in airways disease and pulmonary vascular disease.


Assuntos
Biópsia por Agulha Fina/métodos , Brônquios/patologia , Broncoscopia/métodos , Carcinoma Pulmonar de Células não Pequenas/patologia , Neoplasias Pulmonares/patologia , Biópsia por Agulha Fina/economia , Biópsia por Agulha Fina/instrumentação , Broncoscopia/economia , Competência Clínica/normas , Custos e Análise de Custo , Educação Médica Continuada , Desenho de Equipamento , Previsões , Humanos , Metástase Linfática , Neoplasias do Mediastino/patologia , Estadiamento de Neoplasias , Manejo de Espécimes , Ultrassonografia de Intervenção/economia , Ultrassonografia de Intervenção/métodos
7.
Respiration ; 79(6): 482-9, 2010.
Artigo em Inglês | MEDLINE | ID: mdl-20110643

RESUMO

BACKGROUND: Conventional transbronchial needle aspiration (TBNA) is a cheap, minimally invasive tool for lung cancer staging and diagnosis. Endobronchial ultrasound-guided TBNA (EBUS-TBNA) is more sensitive but is more expensive and less widely available. We describe a prospective analysis of TBNA diagnostic, staging and cost utility in a centre in the UK. OBJECTIVES: To illustrate the potential diagnostic, staging and cost utility of a low cost conventional TBNA service. METHODS: A prospective analysis of 79 TBNA procedures over a 2-year period was performed looking at performance and cost utility in a 'mixed' cohort with variable pre-test probability of malignancy (year 1) followed by a high probability cohort (year 2). RESULTS: TBNA avoided mediastinoscopy in 25% of the cases overall (37% in high probability vs. 13% in the 'mixed' cohort, p = 0.03). The overall prevalence of malignancy was 84%, sensitivity 79%, negative predictive value 58% and accuracy 85%. Diagnostic utility varied with pre-test probability and nodal station. TBNA down-staged 8% of lung cancer patients to receive surgery and confirmed the pre-treatment stage (inoperability) in 74%. TBNA led to theoretical cost savings of GBP 560 per patient. CONCLUSIONS: TBNA can achieve a high diagnostic sensitivity for cancer in high probability patients and stage the majority appropriately, thereby avoiding unnecessary mediastinoscopies and reducing costs. It may also down-stage a minority to have surgery. TBNA is cheap, routinely available and learnable. As EBUS-TBNA will take time to develop due to its costs, all respiratory centres should perform TBNA at flexible bronchoscopy in suspected lung cancer with accessible mediastinal adenopathy.


Assuntos
Biópsia por Agulha , Endossonografia , Linfonodos/patologia , Ultrassonografia de Intervenção , Biópsia por Agulha/economia , Biópsia por Agulha/métodos , Redução de Custos , Endossonografia/economia , Feminino , Humanos , Neoplasias Pulmonares/patologia , Metástase Linfática , Masculino , Mediastinoscopia/economia , Mediastino , Pessoa de Meia-Idade , Valor Preditivo dos Testes , Sensibilidade e Especificidade
8.
QJM ; 102(12): 859-64, 2009 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-19789210

RESUMO

BACKGROUND: New innovative techniques can improve patient care but may not be appropriately funded. Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS) offers a minimally invasive mediastinal staging and diagnostic method for suspected lung cancer. AIM: We report the performance and cost analysis of a newly established EBUS service in a prospective real world cohort of patients to assess the impact of Payment by Results (PbR). DESIGN: Prospective cohort study. METHODS: Fifty-four patients between June 2008 and April 2009 underwent EBUS for evaluation of unexplained mediastinal lymphadenopathy on CT. Cost analysis was performed from local Trust financial data and 2008-09 tariffs. RESULTS: EBUS had an 89% sensitivity, 75% negative predictive value and 92% accuracy for malignancy. EBUS coding was inaccurate in 15.6% of cases. The actual cost of an EBUS is 1252-1433 pounds but is coded as a standard bronchoscopy (561 pounds). EBUS reduces health community costs by 107824 pounds/year, as a result of a Primary Care Trust cost saving of 113968 pounds/year and a Trust cost deficit of 6144 pounds/year. Coding inaccuracies further alter the Primary Care Trust costs. CONCLUSION: Medical innovation is fundamental to improved patient care. EBUS can potentially reduce morbidity for lung cancer patients and save health community costs. However, with PbR the service provider delivers this at a loss as the tariffs do not reflect innovation and because of coding inaccuracies. We suggest tariffs for innovative procedures need to reflect the true cost.


Assuntos
Endossonografia/economia , Neoplasias Pulmonares/diagnóstico , Ultrassonografia de Intervenção/economia , Biópsia por Agulha/métodos , Broncoscopia , Custos e Análise de Custo , Endossonografia/métodos , Feminino , Humanos , Masculino , Valor Preditivo dos Testes , Estudos Prospectivos , Sensibilidade e Especificidade , Reino Unido
9.
Lung Cancer ; 66(3): 355-8, 2009 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-19329220

RESUMO

INTRODUCTION: Local anaesthetic video-assisted thoracoscopy (LAVAT) is a safe, reliable and therapeutic procedure used by respiratory physicians in the management of pleural disease, especially pleural malignancy. We describe a prospective analysis of a UK LAVAT service set up in a tertiary respiratory centre to complement an existing large surgical video-assisted thoracic surgery (VATS) service. METHODS: A prospective analysis of 125 LAVAT procedures over a 34-month period was performed looking at a variety of quality control endpoints comparing them to national thoracic surgical VATS standards. RESULTS: Talc pleurodesis was effective in over 86% of cases and this did not significantly lengthen bed stay (median 4.5 days). Bed stay was also unchanged between the ages of 60-89 years. Over 77% of the 48 patients with proven metastatic pleural lung malignancy or mesothelioma received either surgical decortication or oncological treatment (palliative chemotherapy in 57%). In only 6% were biopsies not possible because of technical factors. LAVAT biopsies had a diagnostic accuracy of 97.4%, sensitivity 95.4%, specificity 100%, positive predictive value 100%, and negative predictive value 94.7%. Our complication rate was 4% and mortality rate 0.8%. DISCUSSION: Our LAVAT service meets surgical VATS standards for diagnosis and safety with a good pleurodesis efficacy rate. It complements our surgical VATS service, offering a pleural diagnostic service for patients with non-complex pleural exudates or too frail for VATS. Our data demonstrate there is a demand and potential for respiratory physicians dealing with pleural malignancy to develop LAVAT and enhance their local lung cancer and pleural diagnostic pathway.


Assuntos
Biópsia , Tempo de Internação , Neoplasias Pulmonares/terapia , Garantia da Qualidade dos Cuidados de Saúde , Cirurgia Torácica Vídeoassistida , Idoso , Idoso de 80 Anos ou mais , Serviços de Saúde , Humanos , Neoplasias Pulmonares/diagnóstico , Neoplasias Pulmonares/economia , Neoplasias Pulmonares/patologia , Pessoa de Meia-Idade , Metástase Neoplásica , Valor Preditivo dos Testes , Estudos Prospectivos , Unidades de Cuidados Respiratórios , Reino Unido
10.
QJM ; 102(5): 329-33, 2009 May.
Artigo em Inglês | MEDLINE | ID: mdl-19244349

RESUMO

BACKGROUND: Correct service costing is essential but may not always be done accurately. AIM: To assess the accuracy of Healthcare Resource Group (HRG) coding allocation for patients undergoing local anaesthetic video-assisted thoracoscopy (LAVAT) against predicted codes under Payment by Results (PbR). DESIGN: Single centre retrospective study. Tertiary respiratory centre in Leicestershire. METHODS: One hundred twenty-five patients undergoing LAVAT from July 2005 to July 2008. MAIN OUTCOME MEASURES: Predicted and actual revenue per LAVAT episode based on predicted and actual HRG codes allocated. RESULTS: Among 125 patients undergoing LAVAT, the actual HRG code matched the predicted code in only 39 cases (31.2%), odds ratio (OR) 0.002, 95% confidence intervals (CIs) 0.0001-0.03, P < 0.0001. In 51 cases (40.8%), this resulted in a median (interquartile range) excess of PbR revenue of 574 pounds (574-1366) per episode; a total estimated overspend of 29,274 pounds. In 35 cases (28.0%), this resulted in a median underspend of --1093 pounds (-1285 to -851) per episode; a total estimated underspend of 38,529 pounds, with a total estimated financial error of 67,529 pounds. The net median (interquartile range) difference for PbR-related revenue was 0 pounds (-89 to + 574). Factors associated with coding discrepancy were longer length of stay (OR = 2.52, 95% CIs = 1.09-5.81, P = 0.03) and talc pleurodesis (OR = 2.25, 95% CI = 1.01-4.99, P = 0.06). CONCLUSION: HRG coding allocation errors occur frequently. The potential financial implications of this are significant for providers and commissioners. Future strategies are required at multiple levels (NHS Trust, Primary Care Trust and Department of Health) to minimize future discrepancies and financial error.


Assuntos
Anestesia Local/economia , Alocação de Recursos/economia , Cirurgia Torácica Vídeoassistida/economia , Análise Custo-Benefício , Humanos , Estudos Retrospectivos , Estatística como Assunto , Cirurgia Torácica Vídeoassistida/métodos , Resultado do Tratamento
11.
Food Chem Toxicol ; 46(9): 3059-68, 2008 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-18619512

RESUMO

Diacylglycerol (DAG) oil is a novel edible oil with similar taste and usability characteristics as conventional edible oils. Recent studies suggest that DAG oil may be helpful in the prevention and management of obesity. The objective of the present two-generation study was to evaluate potential adverse effects of DAG oil on reproductive processes. DAG oil was administered via gavage to rats (30/sex/group) for at least 70 days prior to mating, at dose levels of 0, 1.25, 2.5 or 5.0 ml/kg/day (0, 1160, 2320 and 4630 mg/kg/day). An additional group received a triacylglycerol (TAG) oil with a similar fatty acid composition to DAG oil. The rats were treated throughout the mating, gestation and lactation periods. Administration of DAG or TAG oil did not reveal any toxicologically significant effects on reproductive performance (mating, fertility and copulation/conception indices). DAG oil did not affect mean gestation lengths, the process of parturition, spermatogenic parameters, organ weights, histopathologic findings, mean numbers of pups born, implantation sites and unaccounted sites. F1 and F2 pup viability, live litter sizes, body weights, mean age of attainment of balanopreputial separation and vaginal patency were similar to those in the control group. Based on the results of this study, a dose level of 5.0 ml/kg (4630 mg/kg/day) was considered as the no-observed-adverse-effect level for reproductive and systemic toxicity, and neonatal toxicity.


Assuntos
Dieta , Diglicerídeos/toxicidade , Reprodução/efeitos dos fármacos , Animais , Peso Corporal/efeitos dos fármacos , Ingestão de Alimentos/efeitos dos fármacos , Ciclo Estral/efeitos dos fármacos , Feminino , Lactação/efeitos dos fármacos , Tamanho da Ninhada de Vivíparos/efeitos dos fármacos , Masculino , Nível de Efeito Adverso não Observado , Tamanho do Órgão/efeitos dos fármacos , Parto/efeitos dos fármacos , Gravidez , Ratos , Ratos Sprague-Dawley , Comportamento Sexual Animal/efeitos dos fármacos , Maturidade Sexual , Espermatogênese/efeitos dos fármacos , Desmame
12.
J Adv Nurs ; 59(5): 488-96, 2007 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-17681079

RESUMO

AIM: This paper is a report of a study to explore the views of patients, mental health nurses and psychiatrists involved in mental health nurse supplementary prescribing. BACKGROUND: Medication prescribing by mental health nurses in the United Kingdom is controversial. However, the experience of mental health patients suggests that increasing prescribing capacity could be one strategy to provide a person-centred prescribing approach. METHOD: A qualitative study was carried out in 2005. Semi-structured interviews were conducted with 12 psychiatrists, 11 mental health nurses with prescribing authority, and 12 patients who had been prescribed psychiatric medication by a mental health nurse. Participants were interviewed about positive aspects of supplementary prescribing including the extent of it being evidence-based, person-centred and clinically focussed. FINDINGS: Participants from all three groups had a positive reaction to nurse supplementary prescribing. Mental health nurse prescribing was viewed as evidence-based, person-centred and with an additional focus on physical health. Mental health nurses worked within their levels of competency. Barriers to the implementation of mental health nurse prescribing were nurses' lack of prescribing experience, shortfalls in supervision, insufficient focus on redesigning the service to support the role of the mental health nurse, and preparation for the role. CONCLUSION: Mental health nurse prescribing seems potentially beneficial. However, more rigorous audit and evaluation are needed to confirm its safety, patient satisfaction and health outcomes. Mental health nurse prescribing will require service redesign to ensure that is becomes embedded in the service organizational culture.


Assuntos
Atitude do Pessoal de Saúde , Atitude Frente a Saúde , Prescrições de Medicamentos/enfermagem , Controle de Medicamentos e Entorpecentes , Transtornos Mentais/tratamento farmacológico , Transtornos Mentais/enfermagem , Adulto , Feminino , Humanos , Masculino , Serviços de Saúde Mental/organização & administração , Pessoa de Meia-Idade , Papel do Profissional de Enfermagem , Cultura Organizacional , Inovação Organizacional , Assistência Centrada no Paciente , Autonomia Profissional , Enfermagem Psiquiátrica , Psiquiatria , Segurança , Reino Unido
13.
J Psychiatr Ment Health Nurs ; 13(1): 26-32, 2006 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-16441390

RESUMO

The article describes the management of akathisia by a mental health nurse (MHN) prescriber, working in partnership with the patient. A single-case design was used to evaluate this. It highlights three features: first, MHN can safely prescribe psychiatric medication in combination with concordance therapy. Second, the value base underpinning prescribing practice is partnership, honesty and choice for the patient. Finally, the pharmacological mechanism of antipsychotic medication, which contributes towards akathisia, requires further analysis.


Assuntos
Acatisia Induzida por Medicamentos/tratamento farmacológico , Acatisia Induzida por Medicamentos/enfermagem , Enfermeiros Clínicos/organização & administração , Enfermagem Psiquiátrica/organização & administração , Acatisia Induzida por Medicamentos/etiologia , Acatisia Induzida por Medicamentos/psicologia , Ansiolíticos/uso terapêutico , Antipsicóticos/efeitos adversos , Benzodiazepinas/efeitos adversos , Diazepam/uso terapêutico , Monitoramento de Medicamentos/enfermagem , Prescrições de Medicamentos , Humanos , Masculino , Papel do Profissional de Enfermagem , Avaliação em Enfermagem , Pesquisa em Avaliação de Enfermagem , Olanzapina , Avaliação de Resultados em Cuidados de Saúde , Cooperação do Paciente/psicologia , Autonomia Profissional , Escalas de Graduação Psiquiátrica , Psicoterapia Breve , Esquizofrenia/diagnóstico , Esquizofrenia/tratamento farmacológico , Esquizofrenia/enfermagem , Psicologia do Esquizofrênico , Índice de Gravidade de Doença
14.
J Sch Nurs ; 21(3): 164-9, 2005 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-15898852

RESUMO

When attempting to locate guidelines for designing school nurses' offices, one finds there are minimal resources that address this need. In an effort to solve this concern, the authors were instrumental in writing an article for The Journal of School Nursing published in April 1997. The current article is an updated perspective that defines recommendations to be utilized in new construction or renovation of school nurses' offices. It encompasses information on square footage, design, utilization of space, location, and necessary equipment. Prototypes are provided that apply to elementary, middle school, and high school settings. The article outlines the importance of continued collaboration between the school nurse and key people involved in the planning and construction process, such as the school principal, administrators, and the district engineer.


Assuntos
Arquitetura de Instituições de Saúde/normas , Edifícios de Consultórios Médicos/organização & administração , Serviços de Saúde Escolar/organização & administração , Serviços de Enfermagem Escolar , Local de Trabalho/organização & administração , Eficiência Organizacional , Guias como Assunto , Humanos , Decoração de Interiores e Mobiliário/normas , Administração de Consultório , Gestão da Segurança/organização & administração , Estados Unidos
15.
Mar Pollut Bull ; 51(1-4): 70-5, 2005.
Artigo em Inglês | MEDLINE | ID: mdl-15757709

RESUMO

Adaptive management is the pathway to effective conservation, use and management of Australia's coastal catchments and waterways. While the concepts of adaptive management are not new, applications involving both assessment and management responses are indeed limited at the national and regional scales. This paper outlines the components of a systematic framework for linking scientific knowledge, existing tools, planning approaches and participatory processes to achieve healthy regional partnerships between community, industry, government agencies and science providers to overcome institutional barriers and uncoordinated monitoring. The framework developed by the Coastal CRC (www.coastal.crc.org.au/amf/amf/_index.htm) is hierarchical in the way it displays information to allow associated frameworks to be integrated, and represents a construct in which processes, information, decision tools and outcomes are brought together in a structured and transparent way for adaptive catchment and coastal management. This paper proposes how an adaptive management approach could be used to benefit the implementation of the Reef Water Quality Protection Plan (RWQPP).


Assuntos
Antozoários , Conservação dos Recursos Naturais , Meio Ambiente , Poluição da Água/prevenção & controle , Animais , Formulação de Políticas , Controle de Qualidade , Queensland
16.
Anaesthesia ; 58(5): 412-21, 2003 May.
Artigo em Inglês | MEDLINE | ID: mdl-12693995

RESUMO

We compared the cost-effectiveness of general anaesthetic agents in adult and paediatric day surgery populations. We randomly assigned 1063 adult and 322 paediatric elective patients to one of four (adult) or two (paediatric) anaesthesia groups. Total costs were calculated from individual patient resource use to 7 days post discharge. Incremental cost-effectiveness ratios were expressed as cost per episode of postoperative nausea and vomiting (PONV) avoided. In adults, variable secondary care costs were higher for propofol induction and propofol maintenance (propofol/propofol; p < 0.01) than other groups and lower in propofol induction and isoflurane maintenance (propofol/isoflurane; p < 0.01). In both studies, predischarge PONV was higher if sevoflurane/sevoflurane (p < 0.01) was used compared with use of propofol for induction. In both studies, there was no difference in postdischarge outcomes at Day 7. Sevoflurane/sevoflurane was more costly with higher PONV rates in both studies. In adults, the cost per extra episode of PONV avoided was pound 296 (propofol/propofol vs. propofol/ sevoflurane) and pound 333 (propofol/sevoflurane vs. propofol/isoflurane).


Assuntos
Procedimentos Cirúrgicos Ambulatórios/economia , Anestesia Geral/economia , Custos de Cuidados de Saúde , Náusea e Vômito Pós-Operatórios/economia , Adolescente , Adulto , Idoso , Anestesia Geral/efeitos adversos , Anestesia Geral/métodos , Anestésicos Inalatórios/efeitos adversos , Anestésicos Inalatórios/economia , Anestésicos Intravenosos/efeitos adversos , Anestésicos Intravenosos/economia , Criança , Pré-Escolar , Inglaterra , Humanos , Isoflurano/economia , Éteres Metílicos/economia , Pessoa de Meia-Idade , Náusea e Vômito Pós-Operatórios/induzido quimicamente , Propofol/economia , Estudos Prospectivos , Sevoflurano
17.
Water Sci Technol ; 45(11): 85-90, 2002.
Artigo em Inglês | MEDLINE | ID: mdl-12171370

RESUMO

Rivers provide society with numerous returns. These relate to both the passive and extractive uses of the resources embodied in river environments. Some returns are manifest in the form of financial gains whilst others are non-monetary. For instance, rivers are a source of monetary income for those who harvest their fish. The water flowing in rivers is extracted for drinking and to water crops and livestock that in turn yield monetary profits. However, rivers are also the source of non-monetary values arising from biological diversity. People who use them for recreation (picnicking, swimming, boating) also receive non-monetary returns. The use of rivers to yield these returns has had negative consequences. With extraction for financial return has come diminished water quantity and quality. The result has been a diminished capacity of rivers to yield (non-extractive) environmental returns and to continue to provide extractive values. A river is like any other asset. With use, the value of an asset depreciates because its productivity declines. In order to maintain the productive capacity of their assets, managers put aside from their profits depreciation reserves that can be invested in the repair or replacement of those assets. Society now faces a situation in which its river assets have depreciated in terms of their capacity to provide monetary and non-monetary returns. An investment in river "repair" is required. But, investment means that society gives up something now in order to achieve some benefit in the future. Society thus has to grapple wih the choice between investing in river health and other investments--such as in hospitals, schools, defence etc. - as well as between investing in river health and current consumption--such as on clothes, food, cars etc. A commonly used aid for investment decision making in the public sector is benefit cost analysis. However, its usefulness in tackling the river investment problem is restricted because it requires all benefits and costs to be measured in dollar terms, and many of the benefits arising from investments in river health are non-monetary. In this paper, techniques that enable non-monetary values to be estimated in dollar terms are described. Applications of the techniques to the estimation of the environmental values of rivers are demonstrated. The values estimated are used to demonstrate the extent of returns that are possible from investing in river health.


Assuntos
Conservação dos Recursos Naturais/economia , Abastecimento de Água/economia , Tomada de Decisões , Ecossistema , Meio Ambiente , Formulação de Políticas , Condições Sociais , Poluição da Água/economia
18.
Health Technol Assess ; 6(30): 1-264, 2002.
Artigo em Inglês | MEDLINE | ID: mdl-12709296
19.
Biometrics ; 57(3): 803-12, 2001 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-11550931

RESUMO

Pharmacokinetic (PK) models describe the relationship between the administered dose and the concentration of drug (and/or metabolite) in the blood as a function of time. Pharmacodynamic (PD) models describe the relationship between the concentration in the blood (or the dose) and the biologic response. Population PK/PD studies aim to determine the sources of variability in the observed concentrations/responses across groups of individuals. In this article, we consider the joint modeling of PK/PD data. The natural approach is to specify a joint model in which the concentration and response data are simultaneously modeled. Unfortunately, this approach may not be optimal if, due to sparsity of concentration data, an overly simple PK model is specified. As an alternative, we propose an errors-in-variables approach in which the observed-concentration data are assumed to be measured with error without reference to a specific PK model. We give an example of an analysis of PK/PD data obtained following administration of an anticoagulant drug. The study was originally carried out in order to make dosage recommendations. The prior for the distribution of the true concentrations, which may incorporate an individual's covariate information, is derived as a predictive distribution from an earlier study. The errors-in-variables approach is compared with the joint modeling approach and more naive methods in which the observed concentrations, or the separately modeled concentrations, are substituted into the response model. Throughout, a Bayesian approach is taken with implementation via Markov chain Monte Carlo methods.


Assuntos
Biometria , Hirudinas/análogos & derivados , Modelos Biológicos , Farmacocinética , Farmacologia/estatística & dados numéricos , Anticoagulantes/farmacocinética , Anticoagulantes/farmacologia , Teorema de Bayes , Hirudinas/farmacocinética , Hirudinas/farmacologia , Humanos , Cadeias de Markov , Método de Monte Carlo , Tempo de Tromboplastina Parcial , Proteínas Recombinantes/farmacocinética , Proteínas Recombinantes/farmacologia
20.
J Environ Manage ; 62(3): 301-16, 2001 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-11475087

RESUMO

Choice modelling is an emerging approach to estimating the non-use values of environmental services with multiple attributes. In this paper, results are reported of a choice modelling study conducted in the Herbert River District of North Queensland to estimate the value placed on the protection of natural vegetation in areas suitable for cane production by the local community. Resource use options that vary in the level of environmental protection and the level of agricultural production were presented as a series of choice sets and respondents were asked to choose among a set of three discrete alternatives in a given choice set. The alternatives in each choice set were described by four attributes, pertaining to the area of teatree woodlands, the area of vegetation along rivers and in wetlands, regional income from cane production, and an environmental levy. The responses were analysed together with socio-economic data using a nested-logit discrete-choice model to estimate the community willingness-to-pay for the protection of natural vegetation. The results indicate that the environmental values of wetlands are comparable to returns from commercial production of sugar cane and that the values of teatree woodlands are comparable to returns from extensive grazing. It is argued that land allocation policies should recognise these values in tandem with commercial benefits of production to ensure that resources are used more efficiently.


Assuntos
Agricultura , Conservação dos Recursos Naturais/economia , Tomada de Decisões , Meio Ambiente , Grupos Focais , Modelos Teóricos , Adulto , Idoso , Análise Custo-Benefício , Ecossistema , Feminino , Administração Financeira , Humanos , Masculino , Pessoa de Meia-Idade , Plantas , Opinião Pública
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