Evaluation of ceftriaxone prescriptions in the emergency department of a university hospital: an urgent need for improvement and alternative therapy.

To evaluate the relevance of ceftriaxone prescriptions in an emergency department of a university hospital and suggest whenever possible an antibiotic alternative with a lower ecological impact. All ceftriaxone prescriptions in the first complete week of each month during the year 2016, in the emergency department of the Grenoble university hospital, have been analyzed by an IDS referent in antibiotic prescriptions. Ceftriaxone prescription was considered appropriate if justified (an antibiotic must be used), relevant (ceftriaxone is a good choice), and adapted (in terms of dose, route, and period of administration), regardless of a potential antibiotic association, consistent with international recommendations. We considered patient outcome regarding the quality of initial prescription. Additionally, alternatives were suggested for relevant prescriptions. We included 327 patients, of which ceftriaxone prescriptions were not appropriate in 37.6% of cases: 13.5% were not justified, 12.8% not relevant, and 11.3% not adapted. The main factors associated with unjustified prescriptions were urinary, dermatological, and less frequent infection sites (p < 0.001). The main factors associated with irrelevant prescriptions were patients carrying multi-resistant bacteria (p = 0.002) or already following an antibiotic prescription at emergency department admission (p = 0.024). Antibiotic prescriptions were poorly adapted in patients with a creatinine rate over 150 µmol/L (p < 0.001) and septic shocks (p = 0.032). No difference was found concerning the hospital length of stay comparing appropriate initial prescriptions to inappropriate ones. However, alternatives with lower ecological impact were suggested in 55.2% of relevant prescriptions. In emergency departments, it is crucial to preserve ceftriaxone, selecting better indications and considering alternatives.

Experience feedback committees: A way of implementing a root cause analysis practice in hospital medical departments.

BACKGROUND: The experience feedback committee (EFC) is a tool designed to involve medical teams in patient safety management, through root cause analysis (RCA) within the team. OBJECTIVES: To investigate the functioning of EFCs in the departments of a large university-affiliated hospital in France and to consider its potential contribution to the management of patient safety. METHODS: Cross-sectional, observational study, based on an analysis of the documents produced by the EFCs for 1 year. Data were collected independently by two investigators in meeting minutes, adverse event reports and event analysis reports. RESULTS: The study included all 20 EFCs operating in the hospital's medical departments. During the study year, committees held 164 meetings, reviewed 1707 adverse events, conducted 91 event analyses and decided on 206 corrective actions. The median number of corrective actions adopted by each EFC was five actions (range, 0-62). A root cause analysis (RCA) was present in 76% of the analysis reports, and these analyses were complete in only 23% of the reports. There was also a lack of planning corrective actions: an implementation deadline was only defined in 26% of the actions. CONCLUSIONS: Healthcare professionals adhered to the system-based approach to patient safety, but we observed difficulties in holding regular meetings and deviations from the theoretical framework. These findings confirm the difficulties of practicing RCA in the healthcare setting. Nevertheless, EFCs can be vectors of safety culture and teamwork.

Age-Related Differences in Reperfusion Therapy and Outcomes for ST-Segment Elevation Myocardial Infarction.

OBJECTIVES: To compare timely access to reperfusion therapy and outcomes according to age of older adults with ST-segment elevation myocardial infarction (STEM) managed within an integrated regional system of care. DESIGN: Ongoing, prospective, regional, hospital-based clinical registry. SETTING: Twenty-three public and private hospitals in the Northern Alps in France. PARTICIPANTS: Individuals presenting with STEMI evolving for less than 12 hours from symptom onset between January 2009 and December 2015 (N=4,813; 3,716 (77.2%) <75, 782 (16.2%) 75-84, 315 (6.5%) ≥85). MEASUREMENTS: Delivery of any reperfusion therapy (primary percutaneous coronary intervention (PCI), intravenous fibrinolysis), primary PCI, and timely reperfusion therapy and in-hospital outcomes. RESULTS: The percentages of patients receiving any reperfusion therapy were 92.9% for those younger than 75, 89.0% for those aged 75 to 84, and 78.7% for those aged 85 and older (P < .001). The percentages of patients undergoing primary PCI were 63.7%, 70.3%, 72.4% (P < .001); and the percentages of patients receiving timely delivery of reperfusion therapy were 44.6%, 36.8%, 29.9% (P < .001). In-hospital all-cause mortality was 3.4% for those younger than 75, 10.2% for those aged 75 to 84, and 19.8% for those aged 85 and older (P <.001). In multivariable analysis adjusting for baseline characteristics, timely delivery of reperfusion therapy was associated with lower in-hospital mortality (adjusted odds ratio=0.63, 95% confidence interval=0.46-0.85) with no significant heterogeneity between age groups (P-value for interaction = .45). CONCLUSION: Older adults meeting contemporary eligibility criteria for reperfusion therapy continue to receive delayed reperfusion therapy and experience higher mortality than their younger counterparts.

[From professional practice assessment to continuing professional development: hospital practitioners' involvement and opinion concerning professional practice assessment activities]. / De l’évaluation des pratiques professionnelles au développement professionnel continu : engagement et opinion des praticiens hospitaliers dans les activités d’évaluation des pratiques professionnelles.

INTRODUCTION: The aim of this study was to describe implementation of professional practice assessment (PPA) programmes and participation of physicians and pharmacists in these programmes in a French university hospital. METHODS: We conducted an observational study based on PPA programmes validated in Grenoble university hospital continuing education board between 2007 and 2011. Data were extracted from individual commitment forms filled in by professionals and programme validation forms. The main outcome was the proportion of full-time hospital practitioners who validated at least one PPA programme. RESULTS: Over a 5-year period, 64 PPA programmes and 509 individual commitments involving 366 professionals were validated. At study endpoint, 264 (47%) permanent professionals had validated their mandatory PPA programme. The main methods used in PPA programmes included mortality and morbidity reviews (23), multidisciplinary meetings (23), staff PPA (8) and experience feedback committees (6). The most commonly reported strengths of these programmes included team work (49%) and improvement of patient care (30%). The most commonly reported drawbacks were organizational issues (27%) and unavailability to participate (23%). CONCLUSION: Hospital practitioners and pharmacists adhered to team-based PPA programmes. Implementation of team-base continuing development programmes was the preferred modality during the study period. Implementation of continuing professional development should help support this dynamic.

[Development and functioning of Multiprofessional Primary Care Practices in Rhône-Aipes region]. / Développement et fonctionnement des maisons de santé pluri-professionnelles dans la région Rhône-Alpes.

OBJECTIVE: The need to improve inter-professional cooperation encourages the grouping of primary care professionals in multi professional structures such as primary care practices. The objective of this study was to assess the implementation,organization and operation of primary care practices (PCP) in the French Rhone-Alpes region. METHODS: Cross-sectional survey by self-administered questionnaire of healthcare providers in charge of PCPs in RhOne-Alpes. RESULTS: The study included 35 PCPs across the 8 departments of the RhOne-Alpes region. Most (86%) had been operational since 2009. The number of professionals per PCP ranged from 6 to 30 with a median of 12. The most common~ represented occupations were nurses (125),general practitioners (105) and physical therapists(59). Inter-professional cooperation was based on multidisciplinary consultation meetings in 68% of PCPs and 74% share delectronic patient records. The majority of PCPs (54%) were located in areas with insufficient access to healthcare. Most PCPs(91%) were accessible to people with reduced mobility, 49% had opening hours of more than 60 hours per week, and 54% reported frequent use of third-party payment. CONCLUSION: Dynamic of implementation of PCPs appeared to reflect an attraction of health professionals to collective practices.This trend is consistent with French health care strategy.