RESUMO
INTRODUCTION: From 2013 to 2019, Black women comprised 73% of pregnancy-related deaths in Philadelphia. There is currently a dearth of research on the continuity of midwifery care from initiation of prenatal care through birth in relation to characteristics such as race/ethnicity and income. The aim of this study was to investigate whether race/ethnicity and insurance status were associated with the likelihood of a pregnant person who begins prenatal care with a midwife to remain in midwifery care for birth attendance. METHODS: This was a retrospective cohort study of a diverse population of pregnant patients who gave birth in a large tertiary care hospital and had their first prenatal visit with a certified nurse-midwife (CNM) between June 2, 2009, and June 30, 2020 (n = 5121). We used multivariable, log-binomial regression models to calculate risk ratios of transferring to physician care (vs remaining within CNM care), adjusted for age, race/ethnicity, prepregnancy body mass index, insurance type, and comorbidities. RESULTS: After adjusting for pregnancy-related risk factors, non-Hispanic Black patients (adjusted relative risk [aRR], 1.14; 95% CI, 1.04-1.24) and publicly insured patients (aRR, 1.11; 95% CI, 1.01-1.22) were at higher risk of being transferred to physician care compared with non-Hispanic White and privately insured patients. Secondary analysis revealed that non-Hispanic Black patients had higher risk of transferring and having an operative birth (aRR, 1.35; 95% CI, 1.18-1.55), whereas publicly insured patients were at higher risk of being transferred for reasons other than operative births (aRR, 1.35; 95% CI, 1.18-1.54). DISCUSSION: These findings indicate that Black and publicly insured patients were more likely than White and privately insured patients to transfer to physician care even after adjustment for comorbid conditions. Thus, further research is needed to identify the factors that contribute to racial and economic disparity in continuity of midwifery care.
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Continuidade da Assistência ao Paciente , Cobertura do Seguro , Tocologia , Cuidado Pré-Natal , Humanos , Feminino , Gravidez , Adulto , Tocologia/estatística & dados numéricos , Estudos Retrospectivos , Cobertura do Seguro/estatística & dados numéricos , Philadelphia , Continuidade da Assistência ao Paciente/estatística & dados numéricos , Cuidado Pré-Natal/estatística & dados numéricos , Negro ou Afro-Americano/estatística & dados numéricos , Enfermeiros Obstétricos/estatística & dados numéricos , Adulto Jovem , Seguro Saúde/estatística & dados numéricos , Estudos de Coortes , População Branca/estatística & dados numéricosRESUMO
OBJECTIVE: There is mounting evidence that neighborhoods contribute to perinatal health inequity. We aimed (1) to determine whether neighborhood deprivation (a composite marker of area-level poverty, education, and housing) is associated with early pregnancy impaired glucose intolerance (IGT) and pre-pregnancy obesity and (2) to quantify the extent to which neighborhood deprivation may explain racial disparities in IGT and obesity. STUDY DESIGN: This was a retrospective cohort study of non-diabetic patients with singleton births ≥ 20 weeks' gestation from 1 January 2017-31 December 2019 in two Philadelphia hospitals. The primary outcome was IGT (HbA1c 5.7-6.4%) at <20 weeks' gestation. Addresses were geocoded and census tract neighborhood deprivation index (range 0-1, higher indicating more deprivation) was calculated. Mixed-effects logistic regression and causal mediation models adjusted for covariates were used. RESULTS: Of the 10,642 patients who met the inclusion criteria, 49% self-identified as Black, 49% were Medicaid insured, 32% were obese, and 11% had IGT. There were large racial disparities in IGT (16% vs. 3%) and obesity (45% vs. 16%) among Black vs. White patients, respectively (p < 0.0001). Mean (SD) neighborhood deprivation was higher among Black (0.55 (0.10)) compared with White patients (0.36 (0.11)) (p < 0.0001). Neighborhood deprivation was associated with IGT and obesity in models adjusted for age, insurance, parity, and race (aOR 1.15, 95%CI: 1.07, 1.24 and aOR 1.39, 95%CI: 1.28, 1.52, respectively). Mediation analysis revealed that 6.7% (95%CI: 1.6%, 11.7%) of the Black-White disparity in IGT might be explained by neighborhood deprivation and 13.3% (95%CI: 10.7%, 16.7%) by obesity. Mediation analysis also suggested that 17.4% (95%CI: 12.0%, 22.4%) of the Black-White disparity in obesity may be explained by neighborhood deprivation. CONCLUSION: Neighborhood deprivation may contribute to early pregnancy IGT and obesity-surrogate markers of periconceptional metabolic health in which there are large racial disparities. Investing in neighborhoods where Black patients live may improve perinatal health equity.
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Intolerância à Glucose , Desigualdades de Saúde , Disparidades em Assistência à Saúde , Obesidade , Determinantes Sociais da Saúde , Feminino , Humanos , Gravidez , Negro ou Afro-Americano/estatística & dados numéricos , Intolerância à Glucose/epidemiologia , Intolerância à Glucose/etnologia , Obesidade/epidemiologia , Obesidade/etnologia , Características de Residência , Estudos Retrospectivos , Estados Unidos/epidemiologia , Brancos/estatística & dados numéricos , Características da Vizinhança , Privação Social , Disparidades em Assistência à Saúde/economia , Disparidades em Assistência à Saúde/etnologia , Disparidades em Assistência à Saúde/estatística & dados numéricos , Philadelphia/epidemiologia , Medicaid/economia , Medicaid/estatística & dados numéricos , Equidade em SaúdeAssuntos
Etnicidade , Grupos Raciais , Lactente , Gravidez , Feminino , Humanos , Estados Unidos/epidemiologia , Disparidades nos Níveis de SaúdeRESUMO
Clinicians and researchers use published standards to assess and classify the size and growth of the fetus and newborn infant. Fetal growth is slower on average in Black fetuses as compared with White fetuses, and existing standards differ in whether they are race-specific or not. Here, we apply a health equity lens to the topic of fetal and newborn growth assessment by critically appraising two widely available growth standards. We conclude that using race-based standards is not well-justified and could perpetuate or even worsen inequities in perinatal health outcomes. We therefore recommend that neonatal and perinatal providers remove race from the assessment of fetal and newborn size.
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Desenvolvimento Fetal , Desigualdades de Saúde , Recém-Nascido , Lactente , Gravidez , Feminino , Humanos , População Negra , Parto , Feto , Idade GestacionalRESUMO
Longstanding racial disparities in preterm birth in the US remain incompletely understood. Often investigators use interaction terms or stratify epidemiologic analyses by race and ethnicity to examine disparities. However, these approaches presume differential susceptibility to similar exposures. However, American life remains largely racially segregated. As such, vastly different doses of harmful and beneficial exposures exist across racial and ethnic groups. Differences in exposure patterns and their sources likely explain a larger proportion of racial health disparities (mediation) than differential responses to exposures by race (effect modification). Thus, recently developed, user-friendly mediation analysis may be a more relevant and powerful tool to quantify the contribution of specific exposures to racial disparities. Such statistical methods coupled with evaluation of real-world reduction of exposures to toxicants may be used to focus policymakers' efforts to improve perinatal health equity through targeted interventions.
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Nascimento Prematuro , Gravidez , Feminino , Estados Unidos/epidemiologia , Recém-Nascido , Humanos , Nascimento Prematuro/epidemiologia , Etnicidade , Disparidades nos Níveis de SaúdeRESUMO
A recent shift in public attention to racism, racial disparities, and health equity have resulted in an abundance of calls for relevant papers and publications in academic journals. Peer-review for such articles may be susceptible to bias, as subject matter expertise in the evaluation of social constructs, like race, is variable. From the perspective of researchers focused on neonatal health equity, we share our positive and negative experiences in peer-review, provide relevant publicly available data regarding addressing bias in peer-review from 12 neonatology-focused journals, and give recommendations to address bias and knowledge gaps in the peer review process of health equity research.
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Equidade em Saúde , Neonatologia , Racismo , Recém-Nascido , Humanos , EtnicidadeRESUMO
Neonatal patients and families from historically marginalized and discriminated communities have long been documented to have differential access to health care, disparate health care, and as a result, inequitable health outcomes. Fundamental to these processes is an understanding of what race and ethnicity represent for patients and how different levels of racism act as social determinants of health. The NICU presents a unique opportunity to intervene with regard to the detrimental ways in which structural, institutional, interpersonal, and internalized racism affect the health of newborn infants. The aim of this article is to provide neonatal clinicians with a foundational understanding of race, racism, and antiracism within medicine, as well as concrete ways in which health care professionals in the field of neonatology can contribute to antiracism and health equity in their professional careers.
Assuntos
Equidade em Saúde , Neonatologia , Racismo , Humanos , Lactente , Recém-NascidoAssuntos
População Negra , Mortalidade da Criança , Disparidades nos Níveis de Saúde , Racismo , Adolescente , Saúde do Adolescente , Criança , Saúde da Criança , Pré-Escolar , Atenção à Saúde/métodos , Feminino , Homicídio , Humanos , Lactente , Saúde do Lactente , Masculino , Estados Unidos , Adulto JovemRESUMO
BACKGROUND: Maternal mortality is higher among Black than White people in the United States. Whether Black-White disparities in maternal in-hospital mortality during the delivery hospitalization vary across hospital types (Black-serving vs nonBlack-serving and teaching vs nonteaching) and whether overall maternal mortality differs across hospital types is not known. OBJECTIVE: The aims of this study were to determine whether risk-adjusted Black-White disparities in maternal mortality during the delivery hospitalization vary by hospital types (this is analysis of disparities in mortality within hospital types) and compare risk-adjusted in-hospital maternal mortality among Black-serving and nonBlack-serving teaching and nonteaching hospitals regardless of race (this is an analysis of overall mortality across hospital types). STUDY DESIGN: We performed a population-based, retrospective cohort study of 5,679,044 deliveries among Black (14.2%) and White patients (85.8%) in 3 states (California, Missouri, and Pennsylvania) from 1995 to 2009. A hospital discharge disposition of "death" defined maternal in-hospital mortality. Black-serving hospitals had at least 7% Black obstetrical patients (top quartile). We performed risk adjustment by calculating expected death rates using predictions from logistic regression models incorporating sociodemographics, rurality, comorbidities, multiple gestations, gestational age at delivery, year, state, and mode of delivery. We calculated risk-adjusted risk ratios of mortality by comparing observed-to-expected ratios among Black and White patients within hospital types and then examined mortality across hospital types, regardless of patient race. We quantified the proportion of Black-White disparities in mortality attributable to delivering in Black-serving hospitals using causal mediation analysis. RESULTS: There were 330 maternal deaths among 5,679,044 patients (5.8 per 100,000). Black patients died more often (11.5 per 100,000) than White patients (4.8 per 100,000) (relative risk, 2.38; 95% confidence interval, 1.89-2.98). Examination of Black-White disparities revealed that after risk adjustment, Black patients had significantly greater risk of death (adjusted relative risk, 1.44; 95% confidence interval, 1.17-1.79) and that the disparity was similar within each of the hospital types. Comparison of mortality, regardless of race, across hospital types revealed that among teaching hospitals, mortality was similar in Black-serving and nonBlack-serving hospitals. However, among nonteaching hospitals, mortality was significantly higher in Black-serving vs nonBlack-serving hospitals (adjusted relative risk, 1.47; 95% confidence interval, 1.15-1.87). Notably, 53% of Black patients delivered in nonteaching, Black-serving hospitals compared with just 19% of White patients. Among nonteaching hospitals, 47% of Black-White disparities in maternal in-hospital mortality were attributable to delivering at Black-serving hospitals. CONCLUSION: Maternal in-hospital mortality during the delivery hospitalization among Black patients is more than double that of White patients. Our data suggest this disparity is caused by excess mortality among Black patients within each hospital type, in addition to excess mortality in nonteaching, Black-serving hospitals where most Black patients deliver. Addressing downstream effects of racism to achieve equity in maternal in-hospital mortality will require transparent reporting of quality metrics by race to reduce differential care and outcomes within hospital types, improvements in care delivery at Black-serving hospitals, overcoming barriers to accessing high-quality care among Black patients, and eventually desegregation of healthcare.
Assuntos
Negro ou Afro-Americano/estatística & dados numéricos , Disparidades em Assistência à Saúde/estatística & dados numéricos , Mortalidade Hospitalar/etnologia , Hospitais/estatística & dados numéricos , Mortalidade Materna/etnologia , População Branca/estatística & dados numéricos , Adulto , Estudos de Coortes , Parto Obstétrico/estatística & dados numéricos , Feminino , Hospitais de Ensino/estatística & dados numéricos , Humanos , Gravidez , Complicações na Gravidez/epidemiologia , Estudos Retrospectivos , Estados Unidos/epidemiologiaRESUMO
The similar socioeconomic position of black and Hispanic women coupled with better birth outcomes among Hispanic women is termed the "Hispanic Paradox." However, birth outcome disparities among Hispanic women exist by maternal nativity. Persistent unequal exposure over time to stressors contributes to these disparities. We hypothesized that variation in maternal resilience to stressors also exists by race, ethnicity, and nativity. We utilized data from the Spontaneous Prematurity and Epigenetics of the Cervix study in Boston, MA (n = 771) where resilience was measured mid-pregnancy using the Connor Davidson Resilience Scale 25. We assessed resilience differences by race/ethnicity, by nativity then by race, ethnicity, and nativity together. We also assessed the risk of low resilience among foreign-born women by region of origin. We used Poisson regression to calculate risk ratios for low resilience, adjusting for maternal age, education, and insurance. Resilience did not differ significantly across race/ethnicity or by foreign-born status in the overall cohort. US-born Hispanic women were more likely to be in the low resilience tertile compared with their foreign-born Hispanic counterparts (adjusted RR 3.52, 95% CI 1.18-10.49). Foreign-born Hispanic women also had the lowest risk of being in the low resilience tertile compared with US-born non-Hispanic white women (aRR 0.33, 95% CI 0.11-0.98). Resilience did not differ significantly among immigrant women by continent of birth. Overall, foreign-born Hispanic women appear to possess a resilience advantage. Given that this group often exhibits the lowest rates of adverse birth outcomes, our findings suggest a deeper exploration of resilience among immigrant Hispanic women.
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Emigrantes e Imigrantes/psicologia , Etnicidade/psicologia , Grupos Raciais/psicologia , Resiliência Psicológica , Adulto , Boston , Estudos de Coortes , Emigrantes e Imigrantes/estatística & dados numéricos , Etnicidade/estatística & dados numéricos , Feminino , Hispânico ou Latino/psicologia , Hispânico ou Latino/estatística & dados numéricos , Humanos , Gravidez , Fatores Raciais , Grupos Raciais/estatística & dados numéricosRESUMO
Differences in preterm birth rates between black and white women are the largest contributor to racial disparities in infant mortality. In today's age of precision medicine, analysis of the genome, epigenome, metabolome, and microbiome has generated interest in determining whether these biomarkers can help explain racial disparities. We propose that there are pitfalls as well as opportunities when using precision medicine analyses to interrogate disparities in health. To conclude that racial disparities in complex conditions are genetic in origin ignores robust evidence that social and environmental factors that track with race are major contributors to disparities. Biomarkers measured in omic assays that may be more environmentally responsive than genomics, such as the epigenome or metabolome, may be on the causal pathway of race and preterm birth, but omic observational studies suffer from the same limitations as traditional cohort studies. Confounding can lead to false conclusions about the causal relationship between omics and preterm birth. Methodological strategies (including stratification and causal mediation analyses) may help to ensure that associations between biomarkers and exposures, as well as between biomarkers and outcomes, are valid signals. These epidemiologic strategies present opportunities to assess whether precision medicine biomarkers can uncover biology underlying perinatal health disparities.
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População Negra , Disparidades nos Níveis de Saúde , Medicina de Precisão , Nascimento Prematuro/etnologia , População Branca , População Negra/genética , Tomada de Decisão Clínica , Feminino , Humanos , Gravidez , Nascimento Prematuro/genética , Nascimento Prematuro/prevenção & controle , Fatores Raciais , Medição de Risco , Fatores de Risco , Determinantes Sociais da Saúde , População Branca/genéticaRESUMO
OBJECTIVE: To determine whether prenatal sex hormones from maternal saliva are associated with birth-weight-for-gestational age. STUDY DESIGN: We measured salivary progesterone, testosterone, estradiol, dehydroepiandrosterone (DHEA), and cortisone in 504 pregnant women in a Mexico City cohort. We performed linear and modified Poisson regression to examine associations of log-transformed hormones with birth-weight-for-gestational age z-scores and the risk of small-for-gestational age (SGA) and large-for-gestational age (LGA) adjusting for maternal age, sex, BMI, parity, smoking, education, and socioeconomic status. RESULTS: In total, 15% of infants were SGA and 2% were LGA. Each interquartile range increment in testosterone/estradiol ratio was associated with a 0.12 decrement in birth-weight-for-gestational age z-score (95% CI: -0.27 to -0.02) and a 50% higher risk of SGA versus appropriate-for-gestational age (AGA) (95% CI: 1.13-1.99). CONCLUSION: Higher salivary testosterone/estradiol ratios may affect fetal growth, and identifying the predictors of hormone levels may be important to optimizing fetal growth.
Assuntos
Hormônios Esteroides Gonadais/análise , Saliva/química , Adulto , Peso ao Nascer , Cortisona/análise , Desidroepiandrosterona/análise , Estradiol/análise , Feminino , Macrossomia Fetal , Idade Gestacional , Humanos , Recém-Nascido , Recém-Nascido Pequeno para a Idade Gestacional , Masculino , Paridade , Distribuição de Poisson , Gravidez , Progesterona/análise , Fatores Socioeconômicos , Testosterona/análise , Adulto JovemAssuntos
Nascimento Prematuro/etnologia , Nascimento Prematuro/prevenção & controle , Grupos Raciais , Escolaridade , Exposição Ambiental/efeitos adversos , Feminino , Disparidades nos Níveis de Saúde , Humanos , Recém-Nascido , Gravidez , Política Pública , Fatores Raciais , Meio Social , Estados Unidos/epidemiologiaRESUMO
Adverse birth outcomes such as preterm birth, low-birth weight, and infant mortality continue to disproportionately affect black and poor infants in the United States. Improvements in healthcare quality and access have not eliminated these disparities. The objective of this review was to consider societal factors, including suboptimal education, income inequality, and residential segregation, that together lead to toxic environmental exposures and psychosocial stress. Many toxic chemicals, as well as psychosocial stress, contribute to the risk of adverse birth outcomes and black women often are more highly exposed than white women. The extent to which environmental exposures combine with stress and culminate in racial disparities in birth outcomes has not been quantified but is likely substantial. Primary prevention of adverse birth outcomes and elimination of disparities will require a societal approach to improve education quality, income equity, and neighborhoods.
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Exposição Ambiental , Disparidades nos Níveis de Saúde , Renda , Mortalidade Infantil/etnologia , Recém-Nascido de Baixo Peso , Nascimento Prematuro/etnologia , Classe Social , Segregação Social , Estresse Psicológico/etnologia , Habitação , Humanos , Lactente , Recém-Nascido , Características de ResidênciaRESUMO
PURPOSE OF REVIEW: African Americans disproportionately suffer from leading causes of morbidity and mortality including cardiovascular disease (CVD), cancer, and preterm birth. Disparities can arise from multiple social and environmental exposures, but how the human body responds to these exposures to result in pathophysiologic states is incompletely understood. RECENT FINDINGS: Epigenetic mechanisms, particularly DNA methylation, can be altered in response to exposures such as air pollution, psychosocial stress, and smoking. Each of these exposures has been linked to the above health states (CVD, cancer, and preterm birth) with striking racial disparities in exposure levels. DNA methylation patterns have also been shown to be associated with each of these health outcomes. SUMMARY: Whether DNA methylation mediates exposure-disease relationships and can help explain racial disparities in health is not known. However, because many environmental and adverse social exposures disproportionately affect minorities, understanding the role that epigenetics plays in the human response to these exposures that often result in disease, is critical to reducing disparities in morbidity and mortality.
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OBJECTIVE: Determine if race or ethnicity is associated with missed or late transvaginal cervical length screening in a universal screening program. METHODS: Retrospective cohort study of nulliparous women with singleton gestations and a fetal anatomical ultrasound from 16-24 weeks' gestation from January 2012 to November 2013. We classified women into mutually exclusive racial and ethnic groups: non-Hispanic black (black), Hispanic, Asian, non-Hispanic white (white), and other or unknown race. We used log-binomial regression to calculate the risk ratio (RR) and 95% confidence interval (CI) of missed or late (≥20 weeks' gestation) screening versus optimally timed screening between the different racial and ethnic groups. RESULTS: Among the 2967 women in our study population, 971 (32.7%) had either missed or late cervical length screening. Compared to white women, black (RR: 1.3; 95% CI: 1.1-1.5) and Hispanic (RR:1.2; 95% CI: 1.01-1.5) women were more likely to have missed or late screening. Among women screened, black (versus white) women were more likely to be screened late (RR: 2.2; 95% CI: 1.6-3.1). CONCLUSIONS: Black and Hispanic women may be more likely to have missed or late cervical length screenings.
Assuntos
Medida do Comprimento Cervical/estatística & dados numéricos , Colo do Útero/diagnóstico por imagem , Disparidades nos Níveis de Saúde , Programas de Rastreamento , Grupos Raciais/estatística & dados numéricos , Adulto , Negro ou Afro-Americano/estatística & dados numéricos , Povo Asiático , Distribuição de Qui-Quadrado , Diagnóstico Tardio , Feminino , Hispânico ou Latino/estatística & dados numéricos , Humanos , Cobertura do Seguro/estatística & dados numéricos , Massachusetts , Gravidez , Complicações na Gravidez , Estudos Retrospectivos , População Branca , Adulto JovemRESUMO
PURPOSE: In a prospective prenatal cohort study, we examined associations of second trimester and cord plasma 25-hydroxyvitamin D (25[OH]D) with small-for-gestational age (SGA) and the extent to which vitamin D might explain black/white differences in SGA. METHODS: We studied 1067 white and 236 black mother-infant pairs recruited from eight obstetrical offices early in pregnancy in Massachusetts. We analyzed 25(OH)D levels using an immunoassay and performed multivariable logistic models to estimate the odds of SGA by category of 25(OH)D level. RESULTS: Mean (SD) second trimester 25(OH)D level was 60 nmol/L (SD, 21) and was lower for black (46 nmol/L [SD, 22]) than white (62 nmol/L [SD, 20]) women. Fifty-nine infants were SGA (4.5%), and more black than white infants were SGA (8.5% vs. 3.7%). The odds of SGA were higher with maternal 25(OH)D levels less than 25 versus 25 nmol/L or greater (adjusted odds ratio, 3.17; 95% confidence interval, 1.16-8.63). The increased odds of SGA among black versus white participants decreased from an odds ratio of 2.04(1.04, 4.04) to 1.68(0.82, 3.46) after adjusting for 25(OH)D. CONCLUSIONS: Second trimester 25(OH)D levels less than 25 nmol/L were associated with higher odds of SGA. Our data raise the possibility that vitamin D status may contribute to racial disparities in SGA.
Assuntos
Negro ou Afro-Americano/estatística & dados numéricos , Disparidades nos Níveis de Saúde , Recém-Nascido Pequeno para a Idade Gestacional/sangue , Segundo Trimestre da Gravidez/sangue , Vitamina D/análogos & derivados , População Branca/estatística & dados numéricos , Adulto , Estudos de Coortes , Feminino , Sangue Fetal/química , Desenvolvimento Fetal/fisiologia , Humanos , Recém-Nascido , Modelos Logísticos , Massachusetts , Gravidez , Estudos Prospectivos , Vitamina D/sangueRESUMO
PURPOSE OF REVIEW: Despite advances in medical care, preterm birth and its associated racial/ethnic disparities remain major public health issues. Environmental exposures may contribute to racial disparities in preterm birth. RECENT FINDINGS: Recent work in Iran demonstrated lead levels less than 10 µg/dl to be associated with preterm birth and premature rupture of membranes. Data on air pollution are mixed. A study in California found exposure to nitric oxide species to be associated with preterm birth. However, results from large birth cohorts in the Netherlands found no association. Interestingly, a study in South Korea recently demonstrated that socioeconomic status modifies the association between air pollution and preterm birth. A recent promising study randomized minority pregnant women in Washington, District of Columbia, to cognitive behavioral therapy vs. usual care to decrease exposure to environmental tobacco smoke (ETS). The investigators reported reductions in ETS exposure and the risk of very preterm birth. SUMMARY: Clues about potential mechanisms underlying disparities in preterm birth can be gained from exploring differences in environmental exposures. Investigators should include environmental variables when studying birth outcomes. Such efforts should result in targeted interventions to decrease the incidence of preterm birth and its disparities.
Assuntos
Poluição do Ar/efeitos adversos , Disparidades nos Níveis de Saúde , Exposição Materna/efeitos adversos , Nascimento Prematuro/etnologia , Feminino , Humanos , Chumbo/efeitos adversos , Gravidez , Nascimento Prematuro/etiologia , Fatores de Risco , Fatores Socioeconômicos , Poluição por Fumaça de Tabaco/efeitos adversos , Estados Unidos/epidemiologiaRESUMO
PURPOSE: In the United States, African American women deliver preterm and low birth weight infants two to three times more frequently than their white counterparts. Our objective was to determine whether maternal periconceptional multivitamin (MVI) use is associated with this disparity. METHODS: As a secondary analysis of previously collected data from mothers of non-malformed infants from the Slone Epidemiology Center Birth Defects Study, we conducted a retrospective cohort study of 2331 non-Hispanic white and 133 non-Hispanic black mother/infant pairs from 1998 through 2007. To estimate the effect of MVI use on birth outcomes, linear regression models were used. RESULTS: In white subjects, MVI use was not associated with birth weight, gestational age, or weight-for-gestational-age. However, in black subjects, MVI use was associated with a 536-gram increased birth weight (p=0.001). Black MVI users also had longer gestations (although not statistically significant). When birth weights were adjusted for gestational age using z scores, MVI use was associated with increased fetal growth in black infants (+0.86 z score units, 95% confidence interval: 0.35-1.36). CONCLUSIONS: The present findings suggest MVI use may improve fetal growth and possibly gestational age in the offspring of African American women.