[Considerations for the development of adult vaccination in China].

Adult vaccination is an important component of the life-course immunization for all. Strengthening adult vaccination in China contributes to shrinking immunization gaps between regions and groups, enhancing the overall immunity of our population, and promoting health equity and social prosperity. Chinese adults bear the heavy burden of vaccine preventable diseases such as influenza, pneumococcal diseases and shingles, and have low coverage of vaccines against those diseases, so it is necessary to make efforts to improve adult vaccination development. This article focuses on elaborating the values of adult vaccination, introducing the current status of adult vaccination abroad, and analyzing the challenges and existing foundations for China to provide adult vaccination, and makes suggestions for the building and development of adult vaccination.

Occurrence of fumonisins and aflatoxins in cereals from markets of Hebei Province of China.

Fumonisins B1, B2 and B3 (FB1, FB2 and FB3) and aflatoxins B1 (AFB1), B2 (AFB2), G1 (AFG1) and G2 (AFG2) are both major mycotoxins of food concern, because of their wide range of concentration and possible co-occurrence. Therefore, a contamination survey in corn and wheat flour by liquid chromatography-tandem mass spectrometry was carried out. Quantification of fumonisins and aflatoxins was based on internal calibration (by the use of ¹³C34-fumonisin) and external calibration, respectively. Fumonisins were detected in 95% of corn samples and in 7% of wheat flour samples, with the mean level (FB1 + FB2 + FB3) of 441 µg kg⁻¹ and 0.09 µg kg⁻¹, respectively. Low levels of aflatoxins were detected in 37% of the samples with a mean level (B1 + B2 + G1 + G2) of 0.12 µg kg⁻¹. Fumonisins and aflatoxins were not detected in 29% of the samples analysed. Simultaneous occurrence of fumonisins and aflatoxins was observed in 12% of samples.

Haemodynamic parameters of the hepatic artery and vein can detect liver metastases: assessment using contrast-enhanced ultrasound.

This study was to assess the changes in the haemodynamic parameters of the hepatic artery and vein in the diagnosis of liver metastases by contrast-enhanced ultrasound (CEUS). 52 patients with proven liver metastases (patient group) and 23 normal volunteers (control group) were recruited in this study. Each subject was administered an intravenous bolus injection of SonoVue (0.6 ml). The arrival time in the hepatic artery (AT HA), time to peak in the hepatic artery (TTP HA), peak intensity of the hepatic artery (PI HA), arrival time in the hepatic vein (AT HV), time to peak in the hepatic vein (TTP HV) and peak intensity of the hepatic vein (PI HV) were measured with the use of time-intensity curve software. The hepatic artery to vein transit time (HAVTT) was calculated as the difference between the arrival times in the hepatic artery and the hepatic vein. AT HA, TTP HA, AT HV, TTP HV and HAVTT in the patient group were significantly shorter than those of the control group (P<0.01). PI HA and PI HV in the patient group were significantly higher than those of the control group (P<0.01). These results suggest that CEUS assessment of changes in the haemodynamic parameters of the hepatic artery and vein help to diagnose liver metastases. This functional imaging technique may contribute to the early detection of micrometastases in the liver.

Support vector machine with adaptive parameters in financial time series forecasting.

A novel type of learning machine called support vector machine (SVM) has been receiving increasing interest in areas ranging from its original application in pattern recognition to other applications such as regression estimation due to its remarkable generalization performance. This paper deals with the application of SVM in financial time series forecasting. The feasibility of applying SVM in financial forecasting is first examined by comparing it with the multilayer back-propagation (BP) neural network and the regularized radial basis function (RBF) neural network. The variability in performance of SVM with respect to the free parameters is investigated experimentally. Adaptive parameters are then proposed by incorporating the nonstationarity of financial time series into SVM. Five real futures contracts collated from the Chicago Mercantile Market are used as the data sets. The simulation shows that among the three methods, SVM outperforms the BP neural network in financial forecasting, and there are comparable generalization performance between SVM and the regularized RBF neural network. Furthermore, the free parameters of SVM have a great effect on the generalization performance. SVM with adaptive parameters can both achieve higher generalization performance and use fewer support vectors than the standard SVM in financial forecasting.

[Stroke related knowledge, attitude and behavior of Chinese health professionals].

OBJECTIVE: To understand the knowledge, attitude and behavior (KAB) of Chinese health professionals and the affected factors in stroke. METHODS: 1722 anticipated participants were selected by stratified-random sampling, actual participants were 1609. Out of these participants, 1,537 were eligible for analysis. The data were gathered through self-administrated questionnaire. RESULTS: More than 70% of the health professionals selected the correct answers to some questions, but only 25.7% realized that cerebral arteriosclerosis is the most important cause of ischemic stroke. 57.8% and 48.1% of the health professionals suggested and helped patients to reduce weight and restrict salt, respectively; but only 28.0% suggested and helped patients to do physical exercise in non-acute phase. Analyses of multiple linear regression showed that health professionals' education, title, specialty and training in prevention and control of cardiovascular disease as well as the cardiovascular disease history of patients' family members were positively, significantly and independently related to KAB score. CONCLUSION: Health professionals' KAB score about stroke was low on average, health promotion is the access to improvement of health professionals' KAB level.

[Analysis of the factors related to the change of energy expenditure in burned patients].

OBJECTIVE: To analyze the factors related to the change of energy expenditure in burned patients. METHODS: Indirect calorimetry was employed to detect energy expenditure (EE) dynamically in 45 cases of burned patients and to analyze their change. RESULTS: EE increased immediately postburn and reached top level in about one week (11, 443.78 plus minus 3, 295.32) kJ/d. EE value was positively correlated to the size of burn area. EE was also correlated to the development of the disease. The EE variation happened in the early postburn stage. The degree of variation was positively correlated to the size of burn area. The EE value in patients with medium size burn and inhalation injury was higher than that without inhalation injury. Postoperative EE decreased obviously in patients with major burn who had undergone escharectomy. EE in male patients was higher than that in female. CONCLUSION: Postburn EE varied with some regularity, but was affected by burn depth and size, postburn time, inhalation injury, escharectomy, sex and individual difference.

Asian Pacific cooperative study of allogeneic bone marrow transplantation.

The first cooperative study of the Asian Pacific bone marrow transplantation group included 75 patients with early leukemia who received human leukocyte antigen-matched sibling bone marrow transplants and were randomized into granulocyte colony-stimulating factor and control groups. The selected patients were registered from 10 centers in six countries and areas within Asia (Beijing, Taipei, Hong Kong, Japan, Korea, and Malaysia). The incidence of grades II-IV acute graft-vs.-host disease was 22.2%, and the 2-year survival rate was 62.7%. The period of protective isolation (27.1-66.7 days), period of hospitalization (38.6-130.5 days), and medical costs for 4 months (US $10,300-US $80,803) varied considerably. Good cooperation, i.e., low rate of protocol violation or rapid and precise presentation of case reports, was obtained.

Quantitative assessment of myelin basic protein-reactive T cell entry to the central nervous system by using oligonucleotide probes complementary to VDJ junctional sequences of rat TCR beta-chain.

The VDJ junctional region represents the most diverse part of the antigenic TCR. We have previously reported that of 200 sequenced TCR beta-chains of rat MBP-reactive T cells, rarely did two share sequence homology over the entire CDR3 region. In this study, we demonstrate that sequences of the TCR CDR3 region are excellent clonotypic markers for rat MBP-reactive T cell clones and oligonucleotide probes complementary to the CDR3 region of three T cell clones specifically recognized the TCR from which they were derived, but failed to recognize syngeneic T cells that express a similar TCR beta-chain or T cells that share both V beta and J beta usage. To explore this observation, we determined the ability of MBP-reactive T cell clones to enter the CNS. We were able to show that some MBP-reactive T cell clones have an augmented ability to enter the CNS and that fully-activated T cells have a higher penetrating activity than their less-activated T cell counterparts.

[Assessment of sputum culture and serology for detection of chlamydia pneumoniae in patients with symptomatic acute respiratory tract infection].

OBJECTIVE: To evaluate sputum culture and serology for detection of chlamydia pneumoniae (C. pneumoniae) in adult patients with acute respiratory tract infection and normal subjects. METHODS: Microimmunoflorescence (micro-IF) test for IgG and IgM antibodies to C. pneumoniae specific antigen was performed in every subject. Thirty-seven patients also had sputum HEP-2 cell culture tested for C. pneumoniae. RESULTS: Twenty-six patients (29.7%) with micro-IF IgG titres equal to or greater than 1:512 or/and IgM titres equal to or greater than 1:32 indicated recent infection. Eight patients (21.3%) with positive sputum culture of C. pnuemoniae were identified. No similar titer was shown in control normal subjects. CONCLUSIONS: Acute infection of C. pneumoniae was common in symptomatic patients with acute respiratory tract infection and attention should be drawn to this special illness.