RESUMO
This communication describes a new DRB1*11 allele identified in a familial group of Caucasian individuals from central Italy. The new sequence has been officially named DRB1*11272 by the World Health Organization (WHO) Nomenclature Committee (February 2000). It encodes an HLA antigen serologically recognized as DR11. The sequence variation of this new allele was localized to codon 77 of exon 2. It differs at position 230 from DRB1*11011 allele (A replacing C), and at position 231 from DRB1*1127 (C replacing T). At the amino acid level, the DRB1*11272 mutation is silent with respect to the DRB*1127 phenotype, coding for a synonymous asparagine.
Assuntos
Alelos , Antígenos HLA-DR/genética , Sequência de Aminoácidos , Sequência de Bases , Antígenos HLA-DR/classificação , Cadeias HLA-DRB1 , Humanos , Itália , Dados de Sequência Molecular , Mutagênese , Análise de Sequência , População Branca/genéticaAssuntos
Rejeição de Enxerto/epidemiologia , Rejeição de Enxerto/imunologia , Teste de Histocompatibilidade/métodos , Transplante de Rim/imunologia , Adulto , Azatioprina/uso terapêutico , Biópsia por Agulha , Ciclosporina/uso terapêutico , Quimioterapia Combinada , Feminino , Citometria de Fluxo/métodos , Rejeição de Enxerto/patologia , Antígenos HLA-A , Antígenos HLA-B , Antígenos HLA-DR , Humanos , Imunossupressores/uso terapêutico , Incidência , Transplante de Rim/patologia , Masculino , Metilprednisolona/uso terapêutico , Prednisona/uso terapêutico , Prognóstico , Reoperação , Sensibilidade e EspecificidadeAssuntos
Países em Desenvolvimento , Transplante de Rim , Doadores de Tecidos , Obtenção de Tecidos e Órgãos , Comércio , Custos e Análise de Custo , Europa (Continente) , Humanos , Internacionalidade , Transplante de Rim/economia , Fatores Socioeconômicos , Obtenção de Tecidos e Órgãos/economia , Estados UnidosRESUMO
Seventy-five dialysis patients awaiting renal transplantation were studied. Investigations included single contrast barium meal, serum gastrin assay, gastric acid studies, and fiberoptic gastroduodenoscopy with multiple biopsies. Radiological studies revealed five duodenal ulcers and one gastric ulcer. Endoscopy showed gastroduodenal lesions in 57 patients (49%). Superficial gastritis was present in 50 patients (66.7%), atrophic gastritis in 11 (14.6%), and duodenitis in 30 (40%). Hypergastrinemia was observed in 48 patients (64%). Maximum acid output was markedly elevated in 33 patients. Acid hypersecretion was found to be correlated with the presence of endoscopic lesions and histological evidence of gastritis. Nine of the 11 patients with atrophic gastritis were acid hyposecretors and had low gastrin levels. Pretransplant gastric assessment identified a relevant number of gastroduodenal lesions in these patients. The increased risk of severe posttransplant ulceration justifies thorough gastric assessment and prophylactic antiulcer therapy in all renal transplant candidates.