Design and methods of the mobile assessment of cognition, environment, and sleep (MACES) feasibility study in newly diagnosed breast cancer patients.

Endocrine therapy (ET) for breast cancer treatment is associated with cognitive complaints, but their etiology is poorly understood. To address this, we developed and implemented an ambulatory assessment protocol consisting of wearable activity monitors, brief surveys of affect, context, and perceived impairments, and ultra-brief performance-based measures of cognition. Newly diagnosed, ER/PR+, stage 0-III, female breast cancer patients, were recruited. Ambulatory assessments were conducted on smart phones and wearable activity monitors were used to monitor sleep and physical activity. Participants were asked to complete five 7-day measurement bursts (one before starting ET and one each month for 4 consecutive months while on ET). We observed a consent rate of 36%, 27 women completed the study. Of the women that withdrew, 91% dropped prior to the midpoint of follow up. There were no significant differences in demographics, clinical breast cancer characteristics, sleep or physical activity patterns, or measures of cognition between women who completed versus withdrew. Women who did not complete the study provided fewer valid days of baseline data. In conclusion, while some women may be overwhelmed with their cancer diagnosis, we did not identify any predictive characteristics of women whom did not complete the study. This novel method enables the prospective study of psychological changes associated with cancer treatment, capturing a wide array of information about behavior, experience, and cognition, thus providing a picture of the lived experiences of cancer patients before and during exposure to ET.

Disparities in adolescent sleep health by sex and ethnoracial group.

Improving adolescent sleep health is a national priority for ameliorating health and wellbeing (Healthy People 2020), as the majority of adolescents do not get the minimum recommended amount of 8 h of sleep per night. Prior research has identified sex and ethnoracial disparities in adolescent sleep but has been limited by data availability. National studies have collected reported sleep data, while objective sleep data has been available in community samples only. Using new data from adolescents in the Fragile Families and Child Wellbeing Study, a population-based birth cohort study of children born 1998-2000, we are able to characterize sex and ethnoracial disparities in sleep health in the first national sample of actigraphy-assessed sleep health among adolescents. In cross-sectional analyses, we used linear and logistic regression models to assess sex and ethnoracial disparities in weekday sleep duration, timing, and quality measured using actigraphy collected from 738 adolescents at approximately age 15. We identified sex and ethnoracial group differences in weekday and weekend adolescent sleep duration, with larger disparities on weekends than weekdays. Male adolescents had 27-min shorter nightly sleep durations than females on weeknights. Non-Hispanic black adolescents had 32-min shorter nightly sleep durations than non-Hispanic whites on weekdays and 41-min shorter nightly sleep durations on weekends. While sex disparities persisted after accounting for naps, black-white differences were attenuated by napping such that there was no statistically significant black-white disparity in 24-h sleep on either weekdays or weekends. We did not identify disparities in sleep timing or quality. Future research should investigate the pathways through which these disparities arise, including behavioral and contextual mechanisms.

Ethnoracial sleep disparities among college students living in dormitories in the United States: a nationally representative study.

OBJECTIVES: Ethnoracial disparities in sleep health across the lifecourse, may underlie other disparities in health and well-being among adults in the United States (U.S.). We evaluated if socioenvironmental stressors, which likely differ by the race/ethnicity of college students, may contribute to sleep disparities in this demographic group. DESIGN/MEASUREMENTS: National Health Interview Survey data pooled from 2004 to 2017 were used to test the hypothesis that ethnoracial disparities in sleep exist among college students residing in dormitories in the U.S. SETTING: Nationally representative survey data. PARTICIPANTS: A total of 2,119 college students residing in dormitories (71% White, 16% Black/African-American, 7% Hispanic/Latino, and 6% Asian) participated in the study. RESULTS: The prevalence of short sleep duration was higher among Black/African-Americans than among White students, but not among Hispanics/Latinos and Asians, after adjusting for age, gender, and region of residence. In fully adjusted models, Black/African-Americans, although no longer statistically significant after adjustments, were more likely to report short sleep duration compared with White students (adjusted prevalence ratio; [aPR] = 1.30, 95% confidence interval [CI]: 0.98-1.71). The prevalence of separate insomnia symptoms did not differ by ethnoracial group in adjusted models. Only Asian students had a higher prevalence (aPR = 1.40, 95% CI: 1.12-1.75) of nonrestorative sleep than White students. CONCLUSION: Black/African-American but not Hispanic/Latino or Asian college students were more likely to report short sleep duration than Whites. Insomnia symptoms did not differ between groups, while Asians experienced more nonrestorative sleep. Future studies should investigate the socioenvironmental causes of disparities using longitudinal designs, larger sample sizes, better socioeconomic status (SES) indicators, and objective sleep measures.

Establishing equivalence of a Chinese version of the stroke specific quality of life measure for stroke survivors.

INTRODUCTION: The Stroke Specific Quality of Life Scale is a stroke-specific measure of health-related quality of life. However, there has been no Chinese (Hong Kong) version of the scale. METHODS: A descriptive study was conducted to examine the reliability, validity and factor structure of the translated version (SSQOL-C) among stroke survivors. Participants completed SSQOL-C, and the Chinese versions of the Medical Outcomes Study Short-Form Health Survey (SF-36), Stroke Self-Efficacy Questionnaire (SSEQ-C) and Frenchay Activities Index (FAI). Thirty of these participants completed the same questionnaires after 4 weeks. RESULTS: A total of 135 stroke survivors (mean age 58.90 ± 9.75) were recruited. SSQOL-C had good internal consistency with Cronbach's alphas for each domain ranging from 0.63 to 0.90. Most domains had moderate to high correlations with similar dimensions of SF-36, SSEQ-C, FAI and Barthel ADL Index total scores (Spearman's rho: 0.40-0.77, p < 0.01), suggesting acceptable convergent validity. Principal component analyses suggested an 11-factor model in contrast to the 12-factor model for the original scale with six new factors emerging and five original factors retained. DISCUSSION: The results suggest SSQOL-C is a reliable and valid tool for measuring Chinese stroke survivors' health-related quality of life. More studies are needed to confirm the 11-factor model of the scale. Implications for rehabilitation The translated Chinese version of the Stroke Specific Quality of Life Scale is a reliable and valid tool for measuring Chinese stroke survivors' health-related quality of life. An 11-factor model in contrast to the 12-factor model for the original scale with six new factors emerging and five original factors retained.

Assessment of drowsiness based on ocular parameters detected by infrared reflectance oculography.

STUDY OBJECTIVES: Numerous ocular parameters have been proposed as reliable physiological markers of drowsiness. A device that measures many of these parameters and then combines them into a single metric (the Johns Drowsiness Scale [JDS]) is being used commercially to assess drowsiness in professional drivers. Here, we examine how these parameters reflect changes in drowsiness, and how they relate to objective and subjective indices of the drowsy state in a controlled laboratory setting. DESIGN: A within subject prospective study. PARTICIPANTS: 29 healthy adults (18 males; mean age 23.3 ± 4.6 years; range 18-34 years). INTERVENTIONS: N/A. MEASUREMENTS AND RESULTS: Over the course of a 30-h extended wake vigil under constant routine (CR) conditions, participants were monitored using infrared reflectance oculography (Optalert) and completed bi-hourly neurobehavioral tests, including the Karolinska Sleepiness Scale (KSS) and Psychomotor Vigilance Task (PVT). Ocular-defined increases in drowsiness were evident with extended time awake and during the biological night for all ocular parameters; JDS being the most sensitive marker of drowsiness induced by sleep regulatory processes (p < 0.0001). In addition, the associations between JDS in the preceding 10-min period and subsequent PVT lapses and KSS were stronger (AUC 0.74/0.80, respectively) than any other ocular metric, such that PVT lapses, mean response time (RT), and KSS increased in a dose-response manner as a function of prior JDS score (p < 0.0001). CONCLUSIONS: Ocular parameters captured by infrared reflectance oculography detected fluctuations in drowsiness due to time awake and during the biological night. The JDS outcome was the strongest predictor of drowsiness among those tested, and showed a clear association to objective and subjective measures of drowsiness. Our findings indicate this real-time objective drowsiness monitoring system is an effective tool for monitoring changes in alertness and performance along the alert-drowsy continuum in a controlled laboratory setting.