Effectiveness of Narrative Messaging Styles about the Social Determinants of Health and Health Inequities in Ontario, Canada.

Health inequities are systemic, avoidable, and unjust differences in health between populations. These differences are often determined by social and structural factors, such as income and social status, employment and working conditions, or race/racism, which are referred to as the social determinants of health (SDOH). According to public opinion, health is considered to be largely determined by the choices and behaviours of individuals. However, evidence suggests that social and structural factors are the key determinants of health. There is likely a lack of public understanding of the role that social and structural factors play in determining health and producing health inequities. Public opinion and priorities can drive governmental action, so the aim of this work was to determine the most impactful way to increase knowledge and awareness about the social determinants of health (SDOH) and health inequities in the province of Ontario, Canada. A study to test the effectiveness of four different messaging styles about health inequities and the SDOH was conducted with a sample of 805 adult residents of Ontario. Findings show that messages highlighting the challenges faced by those experiencing the negative effects of the SDOH, while still acknowledging individual responsibility for health, were the most effective for eliciting an empathetic response from Ontarians. These findings can be used to inform public awareness campaigns focused on changing the current public narrative about the SDOH toward a more empathetic response, with the goal of increasing political will to enact policies to address health inequities in Ontario.

In silico prediction of annihilators for triplet-triplet annihilation upconversion via auxiliary-field quantum Monte Carlo.

The energy of the lowest-lying triplet state (T1) relative to the ground and first-excited singlet states (S0, S1) plays a critical role in optical multiexcitonic processes of organic chromophores. Focusing on triplet-triplet annihilation (TTA) upconversion, the S0 to T1 energy gap, known as the triplet energy, is difficult to measure experimentally for most molecules of interest. Ab initio predictions can provide a useful alternative, however low-scaling electronic structure methods such as the Kohn-Sham and time-dependent variants of Density Functional Theory (DFT) rely heavily on the fraction of exact exchange chosen for a given functional, and tend to be unreliable when strong electronic correlation is present. Here, we use auxiliary-field quantum Monte Carlo (AFQMC), a scalable electronic structure method capable of accurately describing even strongly correlated molecules, to predict the triplet energies for a series of candidate annihilators for TTA upconversion, including 9,10 substituted anthracenes and substituted benzothiadiazole (BTD) and benzoselenodiazole (BSeD) compounds. We compare our results to predictions from a number of commonly used DFT functionals, as well as DLPNO-CCSD(T0), a localized approximation to coupled cluster with singles, doubles, and perturbative triples. Together with S1 estimates from absorption/emission spectra, which are well-reproduced by TD-DFT calculations employing the range-corrected hybrid functional CAM-B3LYP, we provide predictions regarding the thermodynamic feasibility of upconversion by requiring (a) the measured T1 of the sensitizer exceeds that of the calculated T1 of the candidate annihilator, and (b) twice the T1 of the annihilator exceeds its S1 energetic value. We demonstrate a successful example of in silico discovery of a novel annihilator, phenyl-substituted BTD, and present experimental validation via low temperature phosphorescence and the presence of upconverted blue light emission when coupled to a platinum octaethylporphyrin (PtOEP) sensitizer. The BTD framework thus represents a new class of annihilators for TTA upconversion. Its chemical functionalization, guided by the computational tools utilized herein, provides a promising route towards high energy (violet to near-UV) emission.