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1.
J Neurol Surg A Cent Eur Neurosurg ; 83(1): 39-45, 2022 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-34100269

RESUMO

BACKGROUND AND STUDY AIMS: Treatment modalities in vestibular schwannoma (VS) are difficult to compare since different techniques for size measurements are used. The purpose of this study was to evaluate the relation between different tumor size grading systems regarding their compatibility as well as the relationship to facial nerve outcome facilitating comparisons of different studies. MATERIAL AND METHODS: In this retrospective study, preoperative magnetic resonance imaging of 100 patients with surgically treated VS was evaluated regarding total tumor volume and anatomical extension based on the Koos and Samii classification, as well as volumetric and maximal diameter measures. Three-dimensional constructive interference in steady state (3D-CISS) and T1 postcontrast volumetric interpolated breath-hold examination (VIBE) sequences were used. Facial nerve function was evaluated according to the House-Brackmann (HB) scale 6 months following complete tumor removal via the retrosigmoid approach. RESULTS: Tumor size showed a moderate influence on postsurgical facial nerve function with correlations not exceeding 0.4. Severe palsy was observed mainly in patients with large tumors with Koos grade 4, Samii grade 4b, respectively a volume of at least 6 cm3 or a maximum diameter of 2.4 cm for HB ≥ 3 and a volume of 7.5 cm3 and maximum diameter of 3.2 cm for HB ≥ 4. In regard to volumetry, the Koos and Samii grading systems were highly comparable, whereas the maximal diameter showed consistently lower correlation values. CONCLUSIONS: The results of our study allow direct comparison of studies on surgery versus radiotherapy of VS. The data allow for translation of tumor sizes based on different grading systems. Comparison of microsurgical, radiotherapeutic and radiosurgical approaches should concentrate on patients with large tumors. Whereas smaller tumors were rarely associated with severe facial palsy, large tumors did not exclude the possibility of weak or no palsy 6 months after surgery.


Assuntos
Neuroma Acústico , Radiocirurgia , Nervo Facial/diagnóstico por imagem , Humanos , Neuroma Acústico/diagnóstico por imagem , Neuroma Acústico/cirurgia , Complicações Pós-Operatórias/diagnóstico por imagem , Estudos Retrospectivos , Resultado do Tratamento
2.
Neuroimage ; 245: 118753, 2021 12 15.
Artigo em Inglês | MEDLINE | ID: mdl-34852278

RESUMO

Diffusion-relaxation correlation NMR can simultaneously characterize both the microstructure and the local chemical composition of complex samples that contain multiple populations of water. Recent developments on tensor-valued diffusion encoding and Monte Carlo inversion algorithms have made it possible to transfer diffusion-relaxation correlation NMR from small-bore scanners to clinical MRI systems. Initial studies on clinical MRI systems employed 5D D-R1 and D-R2 correlation to characterize healthy brain in vivo. However, these methods are subject to an inherent bias that originates from not including R2 or R1 in the analysis, respectively. This drawback can be remedied by extending the concept to 6D D-R1-R2 correlation. In this work, we present a sparse acquisition protocol that records all data necessary for in vivo 6D D-R1-R2 correlation MRI across 633 individual measurements within 25 min-a time frame comparable to previous lower-dimensional acquisition protocols. The data were processed with a Monte Carlo inversion algorithm to obtain nonparametric 6D D-R1-R2 distributions. We validated the reproducibility of the method in repeated measurements of healthy volunteers. For a post-therapy glioblastoma case featuring cysts, edema, and partially necrotic remains of tumor, we present representative single-voxel 6D distributions, parameter maps, and artificial contrasts over a wide range of diffusion-, R1-, and R2-weightings based on the rich information contained in the D-R1-R2 distributions.


Assuntos
Imagem de Difusão por Ressonância Magnética , Processamento de Imagem Assistida por Computador/métodos , Espectroscopia de Ressonância Magnética , Neuroimagem/métodos , Adulto , Neoplasias Encefálicas/diagnóstico por imagem , Neoplasias Encefálicas/tratamento farmacológico , Glioblastoma/diagnóstico por imagem , Glioblastoma/tratamento farmacológico , Voluntários Saudáveis , Humanos , Masculino , Método de Monte Carlo
3.
Transl Stroke Res ; 12(4): 540-549, 2021 08.
Artigo em Inglês | MEDLINE | ID: mdl-32954472

RESUMO

Intracerebral hemorrhage (ICH) prognostication during the acute phase is often subjective among physicians and often affects treatment decisions. The present study explores objective imaging parameters using quantitative corticospinal tract (CST) fiber reconstruction during the acute phase of ICH and correlates these parameters with functional outcome and patient recovery. We prospectively enrolled nonsurgical spontaneous supratentorial ICH patients and obtained an MRI scan on day 5 ± 1. Q-space diffeomorphic reconstruction was performed using DSI Studio, and quantitative anisotropy (QA) was calculated. The CST was reconstructed based on QA. The dichotomized modified Rankin Scale score on day 90 (favorable outcome = 0-2) and Barthel Index (favorable recovery = 100 on day 90 or improvement between discharge and day 90 > 60%) were assessed. Thirty-three patients, median age 72 years (interquartile range (IQR) 64-83), 21 female (64%), 21 (64%) with lobar hemorrhage, median ICH volume on admission 15.0 (IQR 7.0-27.4) mL, were included. Sixteen patients (48%) had a favorable outcome and 24 (73%) had a favorable recovery. The mean number of ipsilesional reconstructed CST fiber pathways was higher in patients with favorable outcomes (153 (standard deviation (SD) 103) vs. 60 (SD 39), p = 0.003) and predicted outcome after adjustment (Exp(B) = 1.016 (95% CI = 1.002-1.030)). QA in the ipsilesional posterior limb of the internal capsule showed a trend towards an association with favorable outcome (Exp(B) = 1.194 (95% CI = 0.991-1.439 (adjusted))). The total (ipsilesional + contralesional) number of reconstructed fiber pathways was associated with favorable recovery (Exp(B) = 1.025 (95% CI = 1.003-1.047 (adjusted))). Quantitative tractography parameters assessed in the acute phase of ICH may represent a promising predictor of long-term outcome and recovery. This might facilitate prognostic evaluation and organization of rehabilitation.


Assuntos
Hemorragia Cerebral , Tratos Piramidais , Idoso , Hemorragia Cerebral/diagnóstico por imagem , Feminino , Humanos , Alta do Paciente , Prognóstico , Tratos Piramidais/diagnóstico por imagem
4.
Acad Radiol ; 27(5): 744-749, 2020 05.
Artigo em Inglês | MEDLINE | ID: mdl-31466889

RESUMO

RATIONALE AND OBJECTIVES: Differences in brain signal intensity ratios (SIRs) of deep brain nuclei in T1-weighted (T1w) magnetic resonance images were reported as an indicator of gadolinium brain retention. Variable methods of image reconstruction and inhomogeneity correction for T1w images exist, which might affect the accuracy of SIRs. The aim of our prospective study was to investigate the effect of flow artifact compensation (FAC) and intensity inhomogeneity correction (IIC) on the dentate nucleus-to-pons and globus pallidus-to-thalamus SIRs in study participants who had previously received multiple doses of gadobutrol. MATERIALS AND METHODS: This study included 76 participants who received five or more gadobutrol-enhanced scans between 2007 and 2017. A control group of 25 participants without gadolinium-based contrast agent application in their patient history was included for comparison. Unenhanced brain magnetic resonance imaging including two T1w spin-echo sequences with and without FAC was performed in all participants. Both sequences were reconstructed with and without IIC. Images were assessed for flow artifacts and SIRs were calculated. RESULTS: Using FAC, a lower proportion of participants had to be excluded from the final analysis of dentate nucleus-to-pons SIR due to flow artifacts (15% versus 46%, p < 0.001). Without IIC, a difference was found between the study and the control group for the dentate nucleus-to-pons ratio (p = 0.004), but not for the same sequence reconstructed with IIC (p = 0.29). For the globus pallidus-to-thalamus ratio, no difference was found between the study and control group. CONCLUSION: The application of an IIC algorithm has significant impact on brain nuclei SIRs for the assessment of gadolinium brain retention.


Assuntos
Gadolínio , Compostos Organometálicos , Artefatos , Encéfalo/diagnóstico por imagem , Núcleos Cerebelares/diagnóstico por imagem , Meios de Contraste , Gadolínio DTPA , Globo Pálido/diagnóstico por imagem , Humanos , Imageamento por Ressonância Magnética , Estudos Prospectivos , Estudos Retrospectivos
5.
Clin Neuroradiol ; 30(4): 721-728, 2020 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31489450

RESUMO

PURPOSE: Evaluation of a new postprocessing method for postoperative control of cochlear implants (CI) based on a single flat detector computed tomography (FD-CT) run and volume rendering of 3D models of the inner ear. METHODS: The FD-CT datasets of CIs were selected and postprocessed to generate both standard multiplanar reconstructions (MPR) and merged volume-rendered 3D datasets (MRD) of the CIs. The MRDs consisted of two different reconstructions (bone/implant) that are automatically layered to avoid manual coregistration inaccuracy. Corresponding datasets were evaluated in consensus reading in terms of qualitative (integrity, position, configuration) and quantitative (insertion depth angle) CI parameters. RESULTS: In total 20 FD-CTs with 20 CIs were successfully postprocessed. Qualitative evaluation of MPR and MRD demonstrated complete congruency (integrity: narray integrity = 20; position: nscala tympani = 13, nscalar translocation = 7; configuration: nharmonic spiralization = 16, ntip fold over = 3, nlooped implant = 1). Adverse intracochlear implant spiralization was identified in all 10 cases with MRD and MPR. Measurement of the insertion depth angle in MRD was equivalent to that in MPR (r = 0.99; P = <0.0001). CONCLUSION: The use of MRD is a helpful method for precise postoperative CI assessment and provides easy detection of incorrect intracochlear spiralization.


Assuntos
Implante Coclear , Implantes Cocleares , Cóclea/diagnóstico por imagem , Cóclea/cirurgia , Humanos , Cuidados Pós-Operatórios , Osso Temporal , Tomografia Computadorizada por Raios X
6.
Interv Neuroradiol ; 25(6): 655-663, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31296064

RESUMO

BACKGROUND: The recent growth of neuro-endovascular treatment has rekindled interest in the use of angiographic techniques for flow assessment. Aneurysm treatment with flow diverters is particularly amenable to such analysis. We analyze contrast time-density curves - recorded within aneurysms before (pre) and immediately after (post) flow diverter implantation to estimate six-month treatment outcomes. METHODS: Fifty-six patients with 65 aneurysms were treated with flow diverters at two institutions. A region of interest was drawn around the aneurysm perimeter in image sequences taken both pre and post angiography, and the temporal variation in grayscale intensity within the aneurysm (time-density curve) was recorded. Eleven parameters were quantified from each time-density curve. Aneurysm occlusion status was recorded six months post treatment. The change in parameters from pre to post treatment was statistically evaluated between aneurysm occluded and non-occluded groups. RESULTS: Of the 11 parameters, eight were significantly different before and immediately after flow diversion. Considering the entire data set, none of the parameters was statistically different between the occluded and non-occluded groups. However, subgroup analyses showed that four variables were significantly different between the aneurysm occluded and non-occluded groups. The sensitivity of these variables to predict aneurysm occlusion at six months ranged from 60% to 89%, while the specificity ranged from 55% to 70%. CONCLUSIONS: Device-induced intra-aneurysmal flow alterations quantified by simple aneurysmal time-density curves can potentially be used to predict long-term outcomes of flow diversion. Large multi-center studies will be required to confirm these findings. Patient-to-patient variability in coagulation may need to be incorporated for clinically relevant predictive values.


Assuntos
Prótese Vascular , Angiografia Cerebral , Aneurisma Intracraniano/diagnóstico por imagem , Aneurisma Intracraniano/cirurgia , Stents , Feminino , Humanos , Masculino , Procedimentos Neurocirúrgicos , Procedimentos Cirúrgicos Vasculares
7.
J Cereb Blood Flow Metab ; 37(2): 632-643, 2017 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-27317652

RESUMO

Knowledge about the topological and structural heterogeneity of the microvasculature is important for diagnosis and monitoring of glioma. A vessel caliber and type-dependent temporal shift in the magnetic resonance imaging signal forms the basis for vascular architecture mapping. This study introduced a clinically feasible approach for assessment of vascular pathologies in gliomas using vascular architecture mapping. Sixty consecutive patients with known or suspected gliomas were examined using vascular architecture mapping as part of the routine magnetic resonance imaging protocol. Maps of microvessel radius and density, which adapted to the vasculature-dependent temporal shift phenomenon, were calculated using a costume-made software tool. Microvessel radius and density were moderately to severely elevated in a heterogeneous, inversely correlated pattern within high-grade gliomas. Additionally, three new imaging biomarkers were introduced: Microvessel type indicator allowing differentiation between supplying arterial and draining venous microvasculature in high-grade gliomas. Vascular-induced bolus peak time shift may presumably be sensitive for early neovascularization in the infiltration zone. Surprisingly, curvature showed significant changes in peritumoral vasogenic edema which correlated with neovascularization in the tumor core of high-grade gliomas. These new magnetic resonance imaging biomarkers give insights into complexity and heterogeneity of vascular changes in glioma; however, histological validations in more well-defined patient populations are required.


Assuntos
Neoplasias Encefálicas/irrigação sanguínea , Encéfalo/irrigação sanguínea , Glioma/irrigação sanguínea , Imageamento por Ressonância Magnética/métodos , Microvasos/diagnóstico por imagem , Adulto , Idoso , Encéfalo/diagnóstico por imagem , Encéfalo/patologia , Neoplasias Encefálicas/diagnóstico por imagem , Neoplasias Encefálicas/patologia , Feminino , Glioma/diagnóstico por imagem , Glioma/patologia , Humanos , Masculino , Microvasos/patologia , Pessoa de Meia-Idade
8.
Neurocrit Care ; 25(1): 40-6, 2016 08.
Artigo em Inglês | MEDLINE | ID: mdl-26690939

RESUMO

BACKGROUND: Our study aimed to evaluate whether the effect of an intra-arterial vasospasm therapy can be assessed quantitatively by in vivo blood flow analysis using the postprocessing algorithm parametric color coding (PCC). METHODS: We evaluated 17 patients presenting with acute clinical deterioration due to vasospasm following subarachnoidal hemorrhage treated with intra-arterial nimodipine application. Pre- and post-interventional DSA series were post-processed by PCC. The relative time to maximum opacification (rTmax) was calculated in 14 arterially and venously located points of interest. From that data, the pre- and post-interventional cerebral circulation time (CirT) was calculated. Additionally, the arterial vessel diameters were measured. Pre- and post-interventional values were compared and tested for significance, respectively. RESULTS: Flow analysis revealed in all arterial vessel segments a non-statistically significant prolongation of rTmax after treatment. The mean CirT was 5.62 s (±1.19 s) pre-interventionally and 5.16 s (±0.81 s) post-interventionally, and the difference turned out as statistically significant (p = 0.039). A significantly increased diameter was measurable in all arterial segments post-interventionally. CONCLUSION: PCC is a fast applicable imaging technique that allows via real-time and in vivo blood flow analysis a quantitative assessment of the effect of intra-arterial vasospasm therapy. Our results seem to validate in vivo that an intra-arterial nimodipine application induces not only vasodilatation of the larger vessels, but also improves the microcirculatory flow, leading to a shortened cerebral CirT that reaches normal range post-interventionally. Procedural monitoring via PCC offers the option to compare quantitatively different therapy regimes, which allows optimization of existing approaches and implementation of individualized treatment strategies.


Assuntos
Angiografia Digital/métodos , Circulação Cerebrovascular/efeitos dos fármacos , Monitorização Neurofisiológica/métodos , Nimodipina/farmacologia , Hemorragia Subaracnóidea/complicações , Vasodilatadores/farmacologia , Vasoespasmo Intracraniano/diagnóstico por imagem , Vasoespasmo Intracraniano/tratamento farmacológico , Adulto , Feminino , Humanos , Infusões Intra-Arteriais , Masculino , Pessoa de Meia-Idade , Nimodipina/administração & dosagem , Vasodilatadores/administração & dosagem , Vasoespasmo Intracraniano/etiologia
9.
Neuroradiology ; 55(6): 709-18, 2013 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-23475161

RESUMO

INTRODUCTION: Using ultra-high-field contrast-enhanced magnetic resonance imaging (MRI), an increase of field strength is associated with a decrease of T 1 relaxivity. Yet, the impact of this effect on signal characteristics and contrast-enhanced pathology remains unclear. Hence, we evaluated the potential of a 17.6-T MRI to assess contrast-enhancing parts of experimentally induced rat gliomas compared to 3 T. METHODS: A total of eight tumor-bearing rats were used for MRI assessments either at 17.6 T (four rats) or at 3 T (four rats) at 11 days after stereotactic implantation of F98 glioma cells into the right frontal lobe. T 1-weighted sequences were used to investigate signal-to-noise-ratios, contrast-to-noise-ratios, and relative contrast enhancement up to 16 min after double-dose contrast application. In addition, tumor volumes were calculated and compared to histology. RESULTS: The 17.6-T-derived contrast-enhancing volumes were 31.5 ± 15.4 mm(3) at 4 min, 38.8 ± 12.7 mm(3) at 8 min, 51.1 ± 12.6 mm(3) at 12 min, and 61.5 ± 10.8 mm(3) at 16 min after gadobutrol injection. Corresponding histology-derived volumes were clearly higher (138.8 ± 8.4 mm(3); P < 0.01). At 3 T, contrast-enhancing volumes were 85.2 ± 11.7 mm(3) at 4 min, 107.3 ± 11.0 mm(3) at 8 min, 117.0 ± 10.5 mm(3) at 12 min, and 129.1 ± 10.0 mm(3) at 16 min after contrast agent application. Averaged histology-derived volumes (139.1 ± 13.4 mm(3)) in this group were comparable to the 16-min volume (P ↔16 min = 0.38). Compared to ultra-high-field MRI, all 3-T-derived volumes were significantly higher (P < 0.02). CONCLUSION: Compared to 3-T-derived images and histology, tumor volumes were underestimated by approximately 50 % at 17.6 T. Hence, contrast-enhanced 17.6-T MRI provided no further benefits in tumor measurement compared to 3 T.


Assuntos
Neoplasias Encefálicas/patologia , Glioma/patologia , Aumento da Imagem/métodos , Imageamento por Ressonância Magnética/métodos , Neoplasias Experimentais/patologia , Compostos Organometálicos , Carga Tumoral , Algoritmos , Animais , Meios de Contraste , Interpretação de Imagem Assistida por Computador/métodos , Masculino , Ratos , Ratos Endogâmicos F344 , Reprodutibilidade dos Testes , Sensibilidade e Especificidade
10.
Eur Radiol ; 21(8): 1779-87, 2011 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-21365196

RESUMO

OBJECTIVE: Careful follow up is necessary after intracranial stenting because in-stent restenosis (ISR) or residual stenosis (RS) is not rare. A minimally invasive follow-up imaging technique is desirable. The objective was to compare the visualisation of stents in Flat Detector-CT Angiography (FD-CTA) after intravenous contrast medium injection (i.v.) with Multi Detector Computed Tomography Angiography (MD-CTA) and Digital Subtracted Angiography (DSA) in an animal model. METHODS: Stents were implanted in the carotid artery of 12 rabbits. In 6 a residual stenosis (RS) was surgically created. Imaging was performed using FD-CTA, MD-CTA and DSA. Measurements of the inner and outer diameter and cross-section area of the stents were performed. Stenosis grade was calculated. RESULTS: In subjective evaluation FD-CTA was superior to MD-CTA. FD-CTA was more accurate compared with DSA than MD-CTA. Cross-sectional area of the stent lumen was significantly larger (p < 0.05) in FD-CTA in comparison to MD-CTA. Accurate evaluation of stenosis was impossible in MD-CTA. There was no statistically significant difference in the stenosis grade of DSA and FD-CTA. CONCLUSION: Our results show that visualisation of stent and stenosis using intravenous FD-CTA compares favourably with DSA and may replace DSA in the follow-up of patients treated with intracranial stents.


Assuntos
Angiografia Cerebral/métodos , Stents , Angiografia Digital , Animais , Meios de Contraste/administração & dosagem , Processamento de Imagem Assistida por Computador , Coelhos , Estatísticas não Paramétricas , Tomografia Computadorizada por Raios X/métodos
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