Sex differences in treatment and prognosis of acute coronary syndrome with interventional management.

OBJECTIVE: Female sex has been associated with differences in diagnostic and management of acute coronary syndrome (ACS). Our aim was to analyze sex differences in ACS with interventional management in a tertiary care hospital. METHODS: Patients with ACS admitted to a Spanish tertiary care referral center were included prospectively and consecutively. All patients included in the study underwent a coronary angiography. RESULTS: From the total cohort of 1214 patients, 290 (24%) were women. Women were older (71 ±â€¯12.8 vs 64 ±â€¯13.4 years, p < 0.001) and showed lower ischemic risk and higher hemorrhagic risk scores (GRACE 159 ±â€¯45 vs 171 ±â€¯42, p = 0.005; CRUSADE 41 ±â€¯19 vs 28 ±â€¯17, p < 0.001). There were no significant differences in time to coronary angiography and revascularization rates between sex groups. A lower proportion of women received high-potency antiplatelet agents (29% vs 41.3%, p = 0.004). In-hospital evolution and one-year mortality were similar between groups. CONCLUSIONS: In our population, there were no gender differences in management and prognosis of ACS. Differences in risk profile among groups could have an influence on antiplatelet therapy.

La Tomografía Computarizada en la evaluación de la afección inflamatoria intestinal / Computed Tomography in the assessment of inflammatory bowel disease

Introducción: las técnicas de imagen tienen un importante papel en el diagnóstico de la enfermedad inflamatoria intestinal constituyendo la Tomografía Computarizada una técnica novedosa por su amplia perspectiva. Objetivos: describir la importancia de la Tomografía Computarizada en la valoración de la enfermedad inflamatoria intestinal e identificar los principales signos tomográficos de esta condición mediante la caracterización de la Enfermedad de Crohn. Material y Métodos: se realizó una búsqueda bibliográfica automatizada consultando las bases de datos de sistemas MEDLINE (motor de búsqueda PubMed) seleccionando aquellas más recientes y de mayor relevancia, preferentemente publicadas en el período del 2007 al 2012 utilizando como descriptores: enterografía por Tomografía Computarizada, enteroclisis por Tomografía Computarizada y Enfermedad de Crohn. Posteriormente, tras un proceso de análisis y síntesis se realizó la redacción del artículo. Desarrollo: se efectúa enfoque comparativo de las principales técnicas por imagen utilizadas en la enfermedad inflamatoria intestinal resaltando la utilidad de la Tomografía Computarizada en la valoración de la pared y lesiones extraluminales asociadas. Además son enunciados los principales hallazgos tomográficos en el diagnóstico, evolución y complicaciones de las mismas teniendo como entidad tipo la Enfermedad de Crohn. Conclusiones: la Tomografía Computarizada constituye una técnica novedosa en la valoración de la enfermedad inflamatoria intestinal, al superar las técnicas convencionales. Además nuevas generaciones de tomógrafos multicorte permitirán mejor valoración de los cambios morfológicos estructurales.

Introduction: image techniques play an important role in the diagnosis of inflammatory bowel diseases and computerized tomography constitutes a novel technique due to its wide scope. Objectives: to describe the importance of computed tomography in the assessment of inflammatory bowel disease and identify the tomographic findings by means of characterising features of Crohn´s disease. Material and Methods: it was made a review through automatized data base MEDLINE (PubMed as search engine) using computed tomography enterography, computed tomography enteroclysis and Crohn´s disease as descriptors. The review was based on the critical analysis of relevant publications, most appearing from 2007 to 2012 . Development: in the present revision article, we carried out a comparative approach of the main imaging techniques used in the inflammatory bowel disease pointing out the usefulness of computed tomography to evaluate the wall and extraluminal lesions and the main tomographic findings in the diagnosis, evolution and their complications were stated taking the Crohn´s disease as an entity type. Conclusions: computed tomography is a novel imaging study in the assessment of inflammatory bowel disease which goes beyond conventional imaging investigations. New generations of multislice computed tomography may provide a better assessment of structural morphologic changes.