[Low-cost reconstructive treatment after resection of distal radius giant cell tumor]. / Tratamiento reconstructivo de bajo costo tras resección de tumor de células gigantes de radio distal.

INTRODUCTION: giant cell tumor (GCT) is a benign intramedullary bone tumor that frequently arises at the ends of long bones. After the distal femur and proximal tibia, the distal radius is the third most affected site with particularly aggressive tumors. Our objective is the presentation of the clinical case of a patient diagnosed with distal radius GCT classified in grade III of Campanacci who received a treatment adjusted to her economic possibilities. CASE REPORT: a 47-year-old female, without economic solvency and with some medical service. Treatment included block resection, reconstruction with distal fibula autograft, and radiocarpal fusion with blocked compression plate. Eighteen months later, the patient had good grip strength (80% on the healthy side) and had fine motor function in the hand. The wrist presented stability with pronation of 85o, supination of 80o, flexion-extension of 0o and a score of 6.7 in the DASH functional outcomes assessment questionnaire. His radiological evaluation five years after his surgery continued with no evidence of local recurrence and pulmonary involvement. CONCLUSION: the result in this patient, together with the published data, indicate that the block tumor resection technique, plus distal fibula autograft and arthrodesis with blocked compression plate provide an optimal result of functionality for the grade III distal radial tumor at low cost.

INTRODUCCIÓN: el tumor de células gigantes (TCG) es un tumor óseo intramedular benigno que surge con frecuencia en los extremos de los huesos largos. Después del fémur distal y la tibia proximal, el radio distal es el tercer sitio más afectado con tumores, particularmente agresivos. Nuestro objetivo es la presentación del caso clínico de una paciente con diagnóstico de TCG de radio distal clasificada en grado III de Campanacci que recibió un tratamiento ajustado a sus posibilidades económicas. REPORTE DE CASO: paciente femenino de 47 años, sin solvencia económica y sin ningún servicio médico. El tratamiento incluyó resección en bloque, reconstrucción con autoinjerto de peroné distal y artrodesis radiocarpiana con placa de compresión bloqueada. Dieciocho meses después, la paciente presentaba una buena fuerza de prensión (80% respecto al lado sano) y tenía una función motora fina en la mano. La muñeca presentó estabilidad con pronación de 85o, supinación de 80o, flexión-extensión de 0o y una puntuación de 6.7 en el cuestionario de evaluación de resultados funcionales DASH. Su evolución radiológica a cinco años después de su cirugía continuó sin datos de recidiva local y afectación pulmonar. CONCLUSIÓN: el resultado en esta paciente, junto con los datos publicados, indican que la técnica de resección tumoral en bloque, más el autoinjerto de peroné distal y la artrodesis con placa de compresión bloqueada proporcionan un resultado óptimo de funcionalidad para el tumor radial distal grado III a bajo costo.

Treatment, outcomes and costs of asthma exacerbations in Chilean children: a prospective multicenter observational study.

OBJECTIVE: To describe potential regional variations in therapies for severe asthma exacerbations in Chilean children and estimate the associated health expenditures. METHODS: Observational prospective cohort study in 14 hospitals over a one-year period. Children five years of age or older were eligible for inclusion. Days with oxygen supply and pharmacological treatments received were recorded from the clinical chart. A basic asthma hospitalization basket was defined in order to estimate the average hospitalization cost for a single patient. Six months after discharge, new visits to the Emergency Room (ER), use of systemic corticosteroids and adherence to the controller treatment were evaluated. RESULTS: 396 patients were enrolled. Patients from the public health system and from the north zone received significantly more days of oxygen, systemic corticosteroids and antibiotics. Great heterogeneity in antibiotic use among the participating hospitals was found, from 0 to 92.3% (ICC 0.34, 95% CI 0.16-0.52). The use of aminophylline, magnesium sulfate and ketamine varied from 0 to 36.4% between the different Pediatric Intensive Care Units (ICC 0.353, 95% CI 0.010-0.608). The average cost per inpatient was of $1910 USD. 290 patients (73.2%) completed the follow-up six months after discharge. 76 patients (26.2%) were not receiving any controller treatment and nearly a fourth had new ER visits and use of systemic corticosteroids due to new asthma exacerbations. CONCLUSIONS: Considerable practice variation in asthma exacerbations treatment was found among the participating hospitals, highlighting the poor outcome of many patients after hospital discharge, with an important health cost.

Evaluación de un programa integral de tratamiento de obesidad y sobrepeso en niños escolares y adolescentes en Santiago de Chile (1999-2006) / Assessment of a multidisciplinary program for the treatment of obesity in children

Background: Medical treatment of obesity requires a multidisciplinary approach including dietary, exercise and behavioral interventions. Aim: To report the results of a multidisciplinary program for the treatment of obesity in children. Patients and Methods: Three hundred twenty four children (155 males), aged between 5 and 18 year, were treated with diet, exercise and behavioral modification, between 1999 and 2006. At baseline and at the end of follow up, weight, height, z score for body mass index (BMI), blood pressure and features of the metabolic syndrome were assessed. Results: z scores for IMC decreased by 0.28 points (95 percent confidence intervals: -0.31 to -0.25). Sixty percent of patients achieved a weight reduction of 5 percent of more of their initial weight. In a multiple linear regression model, weight loss was directly associated with the follow up time and inversely associated with the initial waist circumference. Patients had a reduction of 0.05 z score points of BMI per month (95 percent confidence intervals –0.07 to –0.025; p < 0.001), while adhering to the program. The overall compliance with the three months treatment period was 59 percent. Conclusions: In children and teenagers, a multidisciplinary management of obesity achieves a sustained weight loss, that ifs proportional to the lapse of adherence to the program.

Valoración del sedimento de orina en pacientes que consultan por dolor abdominal en urgencia / Value of urinalysis for the diagnosis of acute abdominal pain

Introducción: El sedimento de orina (SO) es un método útil para el diagnóstico de condiciones que se presentan con dolor abdominal. Sin embargo, frecuentemente no es utilizado adecuadamente. Los objetivos de este trabajo son: evaluar el impacto del SO en el diagnóstico diferencial del dolor abdominal, analizar la concordancia entre el diagnóstico y las alteraciones del SO y evaluar si el resultado del SO predijo un cambio de conducta en el manejo del paciente. Material y Método: Se analizó los SO de los pacientes que consultaron por dolor abdominal en nuestro servicio de urgencia durante 30 días consecutivos (Abril de 2005) y se evaluó la concordancia entre la hipótesis diagnóstica y diagnóstico definitivo sugerido por las características del SO mediante test de Kappa. Resultados: Consultaron 6.930 pacientes en el servicio de urgencia durante el periodo de estudio, 1.106 por dolor abdominal, solicitándose SO a 283 pacientes (25,6 por ciento). La distribución por sexo de pacientes a quienes se solicitó SO fue: 25,7 por ciento hombres,74,2 por ciento mujeres. Las hipótesis diagnósticas realizadas por el cirujano o médico del servicio de urgencia, al momento de solicitar el SO fueron, 10,9 por ciento apendicitis, 41,3 por ciento dolor abdominal inespecífico, 21,5 por ciento cólico renal, 24 por ciento ITU, 2,1 por ciento otras patologías quirúrgicas. Los patrones del SO fueron, 156/283 (55,1 por ciento) normal, 29/283 (10,2 por ciento) contaminación, 45/283 (15,9 por ciento) ITU y 42/283 (14,8 por ciento) hematuria. Al comparar la hipótesis diagnóstica con el diagnóstico de egreso (con el que el paciente fue enviado a su hogar) se encontró una buena concordancia (índice Kappa= 0,607). Sin embargo, al comparar la hipótesis diagnóstica con el diagnóstico definitivo (diagnóstico real dado por el SO y conducta definitiva como la quirúrgica, por ejemplo apendicitis) se encontró una concordancia marginal (índice Kappa= 0,265). Conclusiones: El SO, es un examen...

Epidemiological evaluation of the outcomes of nonsurgical root canal treatment in a large cohort of insured dental patients.

Selected outcomes following initial nonsurgical root canal treatment (NSRCT) procedures were retrospectively assessed using an insurance company database of 110,766 nonsurgical root canal procedures that were completed by endodontists and their referring general dentists. A subset of 44,613 cases, with a minimum required follow-up time of 2 yr, showed incidences of extraction, retreatment and periradicular surgery equal to 5.56%, 2.47%, and 1.41%, respectively. The incidence of subsequent extraction increased with patient age. Teeth that were not restored after root canal therapy were significantly more likely to undergo extraction than restored teeth. Although the practice pattern for endodontists consisted of a significantly higher proportion of molars (48% more; p < 0.001) and a smaller proportion of anterior teeth (43% less; p < 0.001) than general dentists, both groups of providers had comparable rates of untoward events. These data strongly support the hypothesis that the specialist practice provides similar rates of clinical success compared with other providers, even when treating significantly more complex NSRCT cases. Overall, 94.44% of nonsurgical root canal treated teeth remained functional over an average follow-up time of 3.5 yr. These results are an important indication of the benefits of endodontic treatment when provided in an integrated health care delivery system of endodontists and their referring general dentists.

Ethylene oxide cancer risk assessment based on epidemiological data: application of revised regulatory guidelines.

Ethylene oxide (EO) research has significantly increased since the 1980s, when regulatory risk assessments were last completed on the basis of the animal cancer chronic bioassays. In tandem with the new scientific understanding, there have been evolutionary changes in regulatory risk assessment guidelines, that encourage flexibility and greater use of scientific information. The results of an updated meta-analysis of the findings from 10 unique EO study cohorts from five countries, including nearly 33,000 workers, and over 800 cancers are presented, indicating that EO does not cause increased risk of cancers overall or of brain, stomach or pancreatic cancers. The findings for leukemia and non-Hodgkin's lymphoma (NHL) are inconclusive. Two studies with the requisite attributes of size, individual exposure estimates and follow up are the basis for dose-response modeling and added lifetime risk predictions under environmental and occupational exposure scenarios and a variety of plausible alternative assumptions. A point of departure analysis, with various margins of exposure, is also illustrated using human data. The two datasets produce remarkably similar leukemia added risk predictions, orders of magnitude lower than prior animal-based predictions under conservative, default assumptions, with risks on the order of 1 x 10(-6) or lower for exposures in the low ppb range. Inconsistent results for "lymphoid" tumors, a non-standard grouping using histologic information from death certificates, are discussed. This assessment demonstrates the applicability of the current risk assessment paradigm to epidemiological data.

Validity of the Allen Cognitive Levels Assessment: a tri-ethnic comparison.

Schizophrenia is a mental illness which is characterized by severe cognitive deficits and impairments in adaptive functioning. The Allen Cognitive Levels (ACL) Assessment is a screening instrument designed to assess cognitive functioning and to aid clinicians in making judgments about how a patient will be able to perform basic activities of daily living. While the ACL has been widely used, the validity of ACL scores for predicting concurrent adaptive functioning has not been established empirically. The present study examined ACL scores in 110 schizophrenic patients. Scores on the ACL were found to be highly related to scores on the Functional Needs Assessment (r = 0.66), which measures a patient's ability to perform basic activities of daily living. Findings provided some of the first strong evidence that ACL scores reflect adaptive functioning. Correlations between the ACL and the Functional Needs Assessment were equally strong in non-Hispanic whites (n = 31, r = 0.67), Mexican-Americans (n = 58, r = 0.60), and African-Americans (n = 21, r = 0.46). Mean scores did not differ between patients from different ethnic groups. In addition, there was no relationship between ACL scores and level of acculturation within the Mexican-American group. Our data strongly support the hypothesis that the ACL provides a valid and culturally unbiased measure of cognitive functioning that can be helpful in determining how a patient is likely to perform activities of daily living.

[The southern border and international migration from the perspective of NAFTA]. / La frontera sur y las migraciones internacionales ante la perspectiva del Tratado de Libre Comercio.

"Constitution of a trade bloc between Mexico, the United States and Canada through the North American Free Trade Agreement (NAFTA) in this decade has called attention to...the role of Mexico's southern border, Central American conflicts and migrations from that era. Relevant adjustments have been made to Mexico's policy in approaching problems regarding its southern neighbors. These changes respond largely to the perception held by larger economic blocs and migration generated by unequal development levels within these regions and countries." (SUMMARY IN ENG)

[Smoking in Porto Alegre: prevalence and the role of health professionals in its prevention]. / Tabagismo em Porto Alegre: prevalência e o papel dos profissionais da saúde na prevenção.

This study was undertaken in 1988 in order to evaluate the prevalence of smoking, the degree of awareness of smokers and ex-smokers to risks of smoking, and the role of health professionals in the control of smoking in Porto Alegre. A total of 407 persons between 15 and 64 years were interviewed in a population-based survey. Of these, 170 (41.8%) smoked. Among ex-smokers, 85.7% stopped due to awareness of the harm that cigarettes can cause. Only 16.5% of smokers and ex-smokers were warned to the risks of smoking by health professionals before acquiring the habit. After becoming smokers, only 51.4% were warned. These indices are a cause for concern as we believe that prevention is the best approach to control of the smoking epidemic.

Changes in social dynamics associated to the menstrual cycle in the vervet monkey (Cercopithecus aethiops).

Behavioral changes associated to the menstrual cycle in a social group of vervet monkeys (Cercopithecus aethiops) were studied. Three adult females were used as experimental subjects and in these, vaginal smears were taken every other day in order to detect their menstrual cycles. Only the dominant and the mid-ranking female showed regular cycles while the low-ranking female showed amenorrhea. The menstrual cycles were divided into five periods (menstrual, premenstrual, luteal, ovulatory and follicular) which were related to the behavioral data. Social behavior recordings were taken during one hour daily for five consecutive months; the data were adjusted twice in order to follow the cycles of the females with regular menstruations. By plotting in a matrix the relative frequencies of joins and displacements, the social position of each animal as well as the group's social organization and dynamics were evaluated. A clear tendency towards social rejection (emitting less joins and increasing the amount of displacements) was detected during the premenstrual periods of the dominant female which abruptly changed towards affiliation during menstruation. This observation was detected in all group members no matter their age-sex class or social position during the five months of observation. When the data were analyzed following the mid-ranking female's cycle, no consistent changes were apparent. The importance of social stimuli in the modulation and expression of hormone-related behavior is stressed, as well as the need of using social settings in the experimental analyses of premenstrual mood and behavior disorders.