Mapping Chilean clinical research: a protocol for a scoping review and multiple evidence gap maps.

INTRODUCTION: Clinical research broadly aims to influence decision-making in order to promote appropriate healthcare. Funding agencies should prioritise research projects according to needed research topics, methodological and cost-effectiveness considerations, and expected social value. In Chile, there is no local diagnosis regarding recent clinical research that might inform prioritisation for future research funding. This research aims to comprehensively identify and classify Chilean health research studies, elaborating evidence gap maps for the most burdensome local conditions. METHODS AND ANALYSIS: We will search in electronic databases (MEDLINE, Embase, PsycINFO, CINAHL, LILACS and WoS) and perform hand searches to retrieve, identify and classify health research studies conducted in Chile or by authors whose affiliations are based in Chile, from 2000 onwards. We will elaborate evidence matrices for the 20 conditions with the highest burden in Chile (according to the Global Burden of Disease 2019) selected from those defined under the General Regime of the Health Guarantees Act. To elaborate the evidence gap maps, we will consider prioritised interventions and core outcome sets. To identify knowledge gaps and estimate redundant research, we will contrast these gap maps with the available international evidence of high or moderate certainty of evidence, for each specific clinical question. For this purpose, we will search systematic reviews using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach. ETHICS AND DISSEMINATION: No ethical approval is required to conduct this project. We will submit our results in both peer-reviewed journals and scientific conferences. We will aim to disseminate our findings through different academic platforms, social media, local press, among others. The final results will be communicated to local funding agencies and government stakeholders. DISCUSSION: We aim to provide an accurate and up-to-date picture of the research gaps-to be filled by new future findings-and the identification of redundant research, which will constitute relevant information for local decision-makers.

The GRADE approach, Part 2: Evidence to decision frameworksoutlining decision-making in health. / Metodología GRADE, parte 2: de la evidencia a la decisión—esquematizando la toma de decisiones en salud.

The GRADE (Grading of Recommendations Assessment, Development and Evaluation) methodology provides a framework for assessing the certainty of the evidence and making recommendations. The Evidence to Decision Framework (EtD) is a transparent and structured system for formulating health recommendations. Once the problem is identified and the certainty of the evidence is assessed, EtD provides several criteria for formulating a recommendation. These criteria include the trade-off between benefits and harms, patients values and preferences, acceptability, feasibility, resource use, and impact on equity. The resulting recommendations may differ in strength (strong or weak) and direction (for or against). The process is transparent, allowing other users to adjust the framework of recommendations by modifying the criteria to fit the desired context through an adaptation-adoption process. Given the extensive information available on EtD and the GRADE methodology in general, this narrative review seeks to explain the main concepts involved in decision-making in health by using simplified and friendly descriptions, accompanied by practical examples, thus facilitating its understanding by inexperienced readers.

La metodología GRADE (Grading of Recommendations Assessment, Development and Evaluation) provee un método para valorar la certeza de la evidencia y para la formulación de recomendaciones que ayuden en la toma de decisiones en salud. Una vez identificado el problema y valorada la certeza de la evidencia, los marcos de la evidencia a la decisión (Evidence to decision frameworks o EtD) utilizan un sistema transparente y estructurado para formular recomendaciones, en que se consideran criterios como el balance entre beneficios y daños, valores y preferencias de los pacientes, aceptabilidad, factibilidad, equidad y uso de recursos para establecer una recomendación en salud. Esta podrá tener distinta fuerza (fuertes o débiles) y dirección (a favor o en contra). La transparencia de este proceso permite que otros usuarios puedan adaptar un marco de recomendaciones según el contexto deseado, mediante un proceso de adaptación-adopción. Ante la extensa información disponible sobre marcos de la evidencia a la decisión y la metodología GRADE en general, esta revisión narrativa busca entregar una explicación acerca de los principales conceptos involucrados en la toma de decisiones en salud, a través de descripciones simplificadas, amigables y con ejemplos prácticos, con el fin de facilitar su entendimiento por lectores inexpertos.

A qualitative study on the elderly and mental health during the COVID-19 lockdown in Buenos Aires, Argentina - Part 1. / Estudio cualitativo sobre los adultos mayores y la salud mental durante el confinamiento por COVID-19 en Buenos Aires, Argentina - parte 1.

INTRODUCTION: On March 19, 2020, preventive and mandatory social isolation was decreed in Argentina in response to the pandemic caused by the SARS-CoV-2 virus and the disease it causes (COVID-19). This measure aimed to reduce the transmission of the virus and the resulting severe respira-tory condition that frequently besets older adults. However, this measure can also affect the support networks of these isolated people. OBJECTIVES: To explore the emerging needs related to the mental health of isolated older adults in this period and to identify the main support networks they have and the emerging coping strategies in the face of the situation. METHODOLOGY: We carried out an exploratory qualitative study, summoning participants over 60 years of age. Using snowball sampling, a group of researchers contacted them by phone to collect data. The analysis of the findings was triangulated among researchers with different academic backgrounds (medicine, psychology, and sociology). The concepts emerging from the interviews were linked in conceptual networks using an inductive methodology and were mapped into conceptual frameworks available to researchers. Atlas.ti 8 software was used for coding. RESULTS: Thirty-nine participants belonging to the Buenos Aires Metropolitan Area were interviewed between April and July 2020. For greater clarity, the main themes were described in five cross-sectional axes: network configurations, resources and coping strategies, affective states and emo-tions, perceptions and reflections on the future, and actions emerging from the participatory approach. Participants reported distress, anxiety, anger, uncertainty, exhaustion, and expressed fear of contagion from themselves and their loved ones. We identify greater vulnerability in people living alone, in small and closed environments, with weak linkages and networks, or limited access to technologies. We also found vari-ous coping strategies and technology was a fundamental factor in maintaining the bonds. CONCLUSIONS: The findings of this research have implications for decision-making at the individual level, health systems, professional care, and policy devel-opment. Future research may elucidate the regional, temporal, and socioeconomic variations of the phenomena explored in our research.

INTRODUCCIÓN: El 19 marzo de 2020 se decretó el aislamiento social preventivo y obligatorio en Argentina como respuesta a la pandemia por el virus SARS-CoV-2 y la enfermedad que causa (COVID-19). Esta medida tiene por objetivo disminuir la transmisión del virus que puede generar un cuadro respiratorio severo, más frecuentemente en adultos mayores. Sin embargo, esta medida puede afectar sus redes de contención por encontrarse previamente aislados. OBJETIVOS: Explorar las necesidades emergentes relacionadas a la salud mental de adultos mayores aislados en este periodo, e identificar las principales redes de contención con que estos cuentan, como así también las estrategias de afrontamiento emergentes frente a la situación. METODOLOGÍA: Se realizó un estudio cualitativo exploratorio convocando a participantes mayores de 60 años de edad. Mediante un muestreo en bola de nieve, un grupo de investigadores los contactó por teléfono para la recolección de datos. Se trianguló el análisis de los hallazgos entre los investigado-res con distinta formación académica (medicina, psicología y sociología). Los conceptos emergentes de las entrevistas fueron vinculados en redes conceptuales utilizando una metodología inductiva, y mapeando en marcos conceptuales disponibles para los investigadores. Para la codi-ficación se usó el software Atlas.ti 8. RESULTADOS: Se entrevistaron a 39 participantes pertenecientes al área metropolitana de Buenos Aires durante los meses de abril y julio de 2020. Para una presentación más clara, los principales temas fueron descritos en cinco ejes transversales: configuraciones vinculares; recursos y estrategias de afrontamiento; estados afectivos y emociones; percepciones y reflexiones sobre el futuro; y acciones emergentes del enfoque participativo. Los participantes del estudio relataron angustia, ansiedad, enojo, incertidumbre, hartazgo y expresaron el temor al contagio de sí mismos y de sus seres queridos. Se identificaron personas en situación de mayor vulnerabilidad al vivir solas, en ambientes pequeños y cerrados, con redes vinculares frágiles o con limitado manejo de las tecnologías. También encontramos estrategias de afrontamiento variadas para atravesar la situación y la tecnología fue un actor fundamental en el mantenimiento de los vínculos. CONCLUSIONES: Los hallazgos de esta investigación tienen implicancias en la toma de decisiones a nivel individual, de los sistemas de salud, atención profesional y el desarrollo de políticas. Futuras investigaciones pueden dilucidar las variaciones regionales, temporales y socioeconómicas de los fenómenos explorados en nuestra investigación.

A qualitative study on the elderly and accessibility to health services during the COVID-19 lockdown in Buenos Aires, Argentina - Part 2. / Estudio cualitativo sobre los adultos mayores y la accesibilidad a los servicios de salud durante el confinamiento por COVID-19 en Buenos Aires, Argentina - parte 2.

INTRODUCTION: On March 19, 2020, a mandatory lockdown was imposed in Argentina due to the global pandemic caused by SARS-CoV-2. OBJECTIVES: To explore the elderlys healthcare experiences during the lockdown and the problems that may have arisen regarding accessibility to the healthcare system and emerging adaptations to medical care. METHODS: We coded the data using Atlas.ti 8 software and then triangled the analysis among researchers from different backgrounds. Finally, concept maps were developed and themes arising from these were described. RESULTS: Thirty-nine participants were interviewed from the metropolitan area in Buenos Aires from April to July of 2020. The main emerging themes were: 1) access to regularly scheduled consults, 2) access to chronic medication, 3) emergency consultations, and 4) the role of information and communication technologies. Accessibility to the healthcare system was compromised due to reduced outpatient consultations, affecting health checkups, diagnosis, and treatment. However, participants tried to keep their immunizations up to date. Information and communication technologies were used to fill digital prescriptions and online medical consultations. While this was a solution to many, others did not have access to these technologies or had trouble using them. CONCLUSIONS: The global pandemic caused a reduction in outpatient medical consultations. Emerging needs originated new ways of carrying out medical consultations, mainly through information and communication technologies, which was a solution for many but led to the exclusion of others because of the preexisting technology gap.

INTRODUCCIÓN: El 19 marzo de 2020 se decretó el aislamiento social preventivo y obligatorio en Argentina como respuesta a la pandemia por el virus SARS-CoV-2 y la enfermedad que causa, COVID-19. OBJETIVOS: Explorar las experiencias de los adultos mayores con relación al cuidado de su salud durante el confinamiento por COVID-19, los problemas en la accesibilidad al sistema de salud y las adaptaciones emergentes. MÉTODOS: Investigación con abordaje cualitativo. Los participantes fueron adultos mayores de 60 años. Mediante un muestreo en bola de nieve, el equipo investigador contactó telefónicamente a los participantes donde se realizó una entrevista semiestructurada. Se trianguló el análisis de los hallazgos entre los investigadores con distinta formación académica. Se realizaron mapas conceptuales a través de los cuales se eligieron los ejes temáticos a abordar. RESULTADOS: Se entrevistaron a 39 participantes de la Ciudad Autónoma de Buenos Aires y Gran Buenos Aires en el período de abril y julio del año 2020. Los principales temas emergentes fueron: acceso a consultas programadas habituales, acceso a la medicación crónica, consultas agudas y emergentes, y el rol de las tecnologías de información y comunicación. La accesibilidad al sistema de salud se vio comprometida por la disminución de oferta de consultas presenciales, afectando los controles de salud, el diagnóstico y tratamiento de enfermedades. Sin embargo, los participantes intentaron mantener al día sus inmunizaciones. Las tecnologías de la información y comunicación permitieron la emisión de recetas virtuales y las teleconsultas. Si bien esto representó una solución para muchos adultos mayores, también generó un problema para otros que no tenían acceso o no sabían utilizarlas. CONCLUSIÓN: La pandemia afectó la accesibilidad al sistema de salud, principalmente a expensas de un menor acceso a consultas de modalidad presencial. Las necesidades emergentes forzaron la aparición de nuevas estrategias de atención, como las tecnologías de información y comunicación. Esto, si bien significó una solución, también generó nuevos excluidos debido a la brecha tecnológica preexistente.

Instrumentación quirúrgica: de la formación de grado a las competencias requeridas en puestos jerárquicos en la Ciudad Autónoma de Buenos Aires, Argentina / Surgical instrumentation: from undergraduate education to required competences in hierarchical positions in the Autonomous City of Buenos Aires, Argentina

La Licenciatura en Instrumentación Quirúrgica se ha propuesto desarrollar las competencias propias del profesional que actúa en un ámbito de gestión, sin descuidar las que sostiene el instrumentador en su práctica asistencial. El objetivo de esta investigación es articular los contenidos que se brindan en instituciones educativas de formación de grado para instrumentadores quirúrgicos, con las competencias que se requieren para desempeñarse en diferentes puestos jerárquicos. Se realizó un estudio cualitativo, descriptivo, de corte transversal, en el cual se procedió a entrevistar a siete profesionales de la salud que ocupan un cargo jerárquico, utilizando una guía de preguntas abiertas cuyos resultados se trabajaron mediante el análisis de contenido. También se compararon los listados de las asignaturas que se brindan en la Licenciatura para Instrumentadores Quirúrgicos en distintas universidades, cotejando los resultados con los de las entrevistas. Estas evidenciaron que los licenciados ocupan cargos jerárquicos de importancia en las instituciones para las que se desempeñan, donde necesitan poner en juego competencias como la comunicación, la gestión y el liderazgo, entre otras. En las licenciaturas ofrecidas a instrumentadores quirúrgicos se dictan asignaturas que brindan a los profesionales conocimientos generales acerca de gestión, administración, investigación y educación, concluyendo que la formación de grado sirve como base a la hora de adentrarse en el mundo laboral; no obstante, el contenido de las asignaturas varía según cada institución; por lo tanto, el nivel de formación de los licenciados resulta dispar y muchos deben realizar otros cursos o capacitaciones para complementarla. (AU)

The incorporation of a bachelor's degree for surgical-instrumentation practitioners, the academic field aims to develop the competencies required by professionals in management positions while improving the ones of surgical-instrumentation practitioners in an operating room. The following research articulated the academic training provided by different higher education institutions with the competences required to perform in several hierarchical positions. We conducted a qualitative, descriptive and cross-sectional study: we carried out interviews with seven health-professionals who work in different hierarchical roles, using open-ended questions, whose answers were studied through content analysis; and we analyzed the study-plans for Surgical Instrumentation degrees offered by a select group of universities. We also compared the lists of the subjects of the different universities that are offered in the degree for surgical instrumenters, collating the results with the interviews. The interviews revealed that graduates often get middle-level management roles that require not only the competences directly related to their surgical-assistance practice, but also a set of skills regarding human-management, such as administration, communication and leadership among others. Generally, in the analyzed bachelor's degrees curricula, the contents are properly organized and provide students with abilities in management, administration, investigation and education, concluding undergraduate academic education is an added value in graduates' resume for labor insertion. However, it exits a variation in the subject's content between higher education institutions, which creates a disparity in the academic level between graduates from different universities and force some of them to take further courses and trainings to complement their academic background. (AU)

Evidence mapping and quality assessment of systematic reviews on therapeutic interventions for oral cancer.

Purpose: This evidence mapping aims to describe and assess the quality of available evidence in systematic reviews (SRs) on treatments for oral cancer. Materials and methods: We followed the methodology of Global Evidence Mapping. Searches in MEDLINE, EMBASE, Epistemonikos and The Cochrane Library were conducted to identify SRs on treatments for oral cancer. The methodological quality of SRs was assessed using the Assessing the Methodological Quality of Systematic Reviews-2 tool. We organized the results according to identified Population-Intervention-Comparison-Outcome (PICO) questions and presented the evidence mapping in tables and a bubble plot. Results: Fifteen SRs met the eligibility criteria, including 118 individual reports, of which 55.1% were randomized controlled clinical trials. Ten SRs scored "Critically low" methodological quality. We extracted 30 PICOs focusing on interventions such as surgery, radiotherapy, chemotherapy, targeted therapy and immunotherapy; 18 PICOs were for resectable oral cancer, of which 8 were reported as beneficial. There were 12 PICOs for unresectable oral cancer, of which only 2 interventions were reported as beneficial. Conclusion: There is limited available evidence on treatments for oral cancer. The methodological quality of most included SRs scored "Critically low". The main beneficial treatment reported by authors for patients with resectable oral cancer is surgery alone or in combination with radiotherapy or chemotherapy. Evidence about the benefits of the treatments for unresectable oral cancer is lacking. These findings highlight the need to address future research focused on new treatments and knowledge gaps in this field, and increased efforts are required to improve the methodology quality and reporting process of SRs on treatments for oral cancer.