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2.
Toxicol Lett ; 351: 135-144, 2021 Oct 15.
Artigo em Inglês | MEDLINE | ID: mdl-34500033

RESUMO

This article provides guidance into the quantitative risk assessment of skin exposures to metals. The use of wipe sampling methodologies has been shown to be standardised and effective for skin exposure assessment to metals. However, there is a lack of guidance documents and frameworks available to evaluate the level of health risk to workers from skin exposures to metals. Adverse health effects from exposures to metals have been described in the literature (Fernández-Nieto et al. 2006; Herman et al. 2006; Kreiss et al. 1996). Monitoring of workplace exposures typically focuses on the assessment of respiratory exposures. To provide a safe workplace there is a need to ensure all routes of exposure are risk assessed and controlled. The goal of this article was to develop skin (surface) exposure limits to metals, using the construction industry as a test environment, to quantitatively assess worker health risk of skin exposures to metals. This research concluded it was not feasible to establish single quantitative skin exposure limits to metals due to the many assumptions surrounding dermal exposures. A range of acceptable exposure limits are presented.


Assuntos
Metais/administração & dosagem , Exposição Ocupacional/prevenção & controle , Pele/efeitos dos fármacos , Animais , Testes de Carcinogenicidade , Indústria da Construção , Monitoramento Ambiental , Humanos , Manufaturas , Concentração Máxima Permitida , Metais/toxicidade , Medição de Risco
3.
Int Arch Occup Environ Health ; 93(7): 789-803, 2020 10.
Artigo em Inglês | MEDLINE | ID: mdl-32170361

RESUMO

PURPOSE: This article summarises a systematic literature review of skin exposure assessment methods and concepts for deriving skin (dermal) exposure limits for metals, using the construction industry, where there is a high prevalence of occupational skin exposures as a test environment. METHODS: A systematic literature review was undertaken across ten databases key to Occupational Health and Safety. Articles were considered for inclusion if they evaluated skin or surface exposure to metals or discussed the feasibility of establishing skin or surface exposure limits in an occupational setting. Only full text, peer-reviewed articles were retrieved. All publications up to 30/06/2019 were considered. The quality of evidence was evaluated based on methodology. RESULTS: A total of 71 studies were selected for inclusion in the review with 49 on skin exposure assessment methods for metals and 22 relating to the derivation of skin exposure limits. The use of wipe sampling methodologies was shown to be standardised and effective for sampling skin exposures to metals. In contrast, there was no scientific consensus on the concept of quantitative skin exposure limits. CONCLUSION: There was greater strength of evidence that wipe methods for the measurement of metals would work well. A research gap with respect to the development of health-based skin exposure limits for metals was identified. Frameworks currently proposed for devising quantitative skin exposure limits are provided. These approaches could be adapted to improve the risk assessment of skin exposures to surface metal contaminants.


Assuntos
Indústria da Construção , Metais/análise , Exposição Ocupacional/análise , Pele , Humanos , Medição de Risco/métodos , Absorção Cutânea
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