RESUMO
BACKGROUND: The aim of our study was to determine whether prediabetes increases cardiovascular (CV) risk compared to the non-prediabetic patients in our hypertensive population. Once this was achieved, the objective was to identify relevant CV prognostic features among prediabetic individuals. METHODS: We included hypertensive 1652 patients. The primary outcome was a composite of incident CV events: cardiovascular death, stroke, heart failure and myocardial infarction. We performed a Cox proportional hazard regression to assess the CV risk of prediabetic patients compared to non-prediabetic and to produce a survival model in the prediabetic cohort. RESULTS: The risk of developing a CV event was higher in the prediabetic cohort than in the non-prediabetic cohort, with a hazard ratio (HR)â¯=â¯1.61, 95% CI 1.01-2.54, pâ¯=â¯0.04. Our Cox proportional hazard model selected age (HRâ¯=â¯1.04, 95% CI 1.02-1.07, pâ¯<â¯0.001) and cystatin C (HRâ¯=â¯2.4, 95% CI 1.26-4.22, pâ¯=â¯0.01) as the most relevant prognostic features in our prediabetic patients. CONCLUSIONS: Prediabetes was associated with an increased risk of CV events, when compared with the non-prediabetic patients. Age and cystatin C were found as significant risk factors for CV events in the prediabetic cohort.