Predictors of medication adherence among patients with severe psychiatric disorders: findings from the baseline assessment of a randomized controlled trial (Tecla).

BACKGROUND: Schizophrenia and bipolar disorder are characterized by a high disease burden. Antipsychotic medication is an essential part of the treatment. However, non-adherence is a major problem. Our aim was to examine potential determinants of non-adherence for patients with severe mental disorders. METHODS: Baseline data of the study "Post stationary telemedical care of patients with severe psychiatric disorders" (Tecla) were used. Medication adherence was assessed with the Medication Adherence Report Scale German version (MARS-D). A logistic regression was calculated with age, sex, education, employment status, level of global functioning, social support and intake of typical and atypical antipsychotics as predictors. RESULTS: N = 127 participants were included in the analysis (n = 73 men, mean age 42 years). The mean MARS-D Score was 23.4 (SD 2.5). The most common reason for non-adherence was forgetting to take the medicine. Significant positive determinants for adherence were older age (OR 1.02, 95% CI 1.011-1.024, p < 0.0001), being employed (OR 2.46, 95% CI 1.893-3.206, p < 0.0001), higher level of global functioning (overall measure of how patients are doing) (OR 1.02, 95% CI 1.012-1.028, p < 0.0001), having social support (OR 1.02, 95% CI 1.013-1.026, p < 0.0001), and intake of typical antipsychotics (OR 2.389, 95% CI 1.796-3.178, p < 0.0001). A negative determinant was (female) sex (OR 0.73, 95% CI 0.625-0.859, p = 0.0001). CONCLUSIONS: Especially employment, functioning and social support could be promising targets to facilitate adherence in patients with schizophrenia or bipolar disorder. TRIAL REGISTRATION: This study is retrospectively registered at the German Clinical Trials Register with the trial registration number DRKS00008548 at 21/05/2015.

Assessment of subjective emotional valence and long-lasting impact of life events: development and psychometrics of the Stralsund Life Event List (SEL).

BACKGROUND: Life events (LEs) are associated with future physical and mental health. They are crucial for understanding the pathways to mental disorders as well as the interactions with biological parameters. However, deeper insight is needed into the complex interplay between the type of LE, its subjective evaluation and accompanying factors such as social support. The "Stralsund Life Event List" (SEL) was developed to facilitate this research. METHODS: The SEL is a standardized interview that assesses the time of occurrence and frequency of 81 LEs, their subjective emotional valence, the perceived social support during the LE experience and the impact of past LEs on present life. Data from 2265 subjects from the general population-based cohort study "Study of Health in Pomerania" (SHIP) were analysed. Based on the mean emotional valence ratings of the whole sample, LEs were categorized as "positive" or "negative". For verification, the SEL was related to lifetime major depressive disorder (MDD; Munich Composite International Diagnostic Interview), childhood trauma (Childhood Trauma Questionnaire), resilience (Resilience Scale) and subjective health (SF-12 Health Survey). RESULTS: The report of lifetime MDD was associated with more negative emotional valence ratings of negative LEs (OR = 2.96, p < 0.0001). Negative LEs (b = 0.071, p < 0.0001, ß = 0.25) and more negative emotional valence ratings of positive LEs (b = 3.74, p < 0.0001, ß = 0.11) were positively associated with childhood trauma. In contrast, more positive emotional valence ratings of positive LEs were associated with higher resilience (b = - 7.05, p < 0.0001, ß = 0.13), and a lower present impact of past negative LEs was associated with better subjective health (b = 2.79, p = 0.001, ß = 0.05). The internal consistency of the generated scores varied considerably, but the mean value was acceptable (averaged Cronbach's alpha > 0.75). CONCLUSIONS: The SEL is a valid instrument that enables the analysis of the number and frequency of LEs, their emotional valence, perceived social support and current impact on life on a global score and on an individual item level. Thus, we can recommend its use in research settings that require the assessment and analysis of the relationship between the occurrence and subjective evaluation of LEs as well as the complex balance between distressing and stabilizing life experiences.

[Assessment of mild cognitive impairment and dementia in epidemiologic studies. An overview on the current state of research in Germany]. / Erfassung leichter kognitiver Störungen und demenzieller Erkrankungen in epidemiologischen Studien. Ein Überblick über den aktuellen Forschungsstand in Deutschland.

OBJECTIVE: We sought to provide an overview on the assessment of mild cognitive impairment and dementia in epidemiological studies from Germany. METHODS: We conducted a literature search in the databases Pubmed and PsycInfo. RESULTS: Literature search identified 31 relevant studies using a broad spectrum of methods and neuropsychological instruments. CONCLUSION: Further efforts are necessary to establish a generally accepted core set of instruments enabling a harmonized assessment of mild cognitive impairment and dementia in epidemiological studies. Such a core set should comprise neuropsychological tests but also standardized questionnaires on subjective cognitive impairment and impairment in activities of daily living. If possible, third-party information (proxy interviews) should be included.

[Is there an association between intra-familiar sexual abuse and sexual offences in later life?]. / Gibt es eine Assoziation zwischen familiärem sexuellen Missbrauch und späteren Sexualstraftaten?

OBJECTIVE: 12-35% of all sexual delinquents report victimization through early sexual abuse. To date, studies are based on small samples and mostly come from English-language countries. METHODS: As part of an interdisciplinary study on the human rights situation in long-term imprisonment, we examined 1,055 prisoners from 11 countries in Europe with the posttraumatic stress diagnostic scale (PDS) concerning their traumas in relation to their offences. RESULTS: Sexual delinquents who reported own prior sexual abuse within the family had a fourfold increase in committing sexual offences later in their life compared to other offenders. CONCLUSIONS: A detailed trauma history which includes sexual offences within the family is essential for adequate therapy and relapse prevention.

[A brief instrument for the assessment of childhood abuse and neglect: the childhood trauma screener (CTS)]. / Ein Screeninginstrument für Missbrauch und Vernachlässigung in der Kindheit: der Childhood Trauma Screener (CTS).

OBJECTIVE: There is a lack of a psychometrically sound screening questionnaire that assesses important dimensions of traumatic experiences during childhood and adolescence in a time-efficient way. Based on the German version of the "Childhood Trauma Questionnaire" (CTQ, 28 items) we developed a five-item self-report childhood trauma screener (CTS) that covers sexual, emotional and physical abuse and emotional and physical neglect. METHOD: The data set of the SHIP-LEGEND study (n = 1668) was used to extract five items of the CTQ that optimally covered the five dimensions and showed a high correlation with the total score. In two validation samples (clinical sample [n = 211] and subjects from the BiDirect study [n = 288]) the psychometric properties of the CTS were evaluated. RESULTS: The correlations between the five CTS Items and the corresponding dimensions from the CTQ were r = 0.55 to 0.87 (p < 0.0001) within the clinical sample. Furthermore, we found high correlations (r = 0.88; p < 0.0001) with the total CTQ score. The internal consistency was 0.757 (Cronbachs α). CONCLUSION: The CTS is a reliable, valid and economic screener for the retrospective assessment of adverse childhood experiences especially in large epidemiological studies.

Gender-dependent associations between socioeconomic status and tooth loss in working age people in the Study of Health in Pomerania (SHIP), Germany.

OBJECTIVES: Individual impact and the effect magnitude of socioeconomic key indicators (income, education and occupation) and of gender on oral health are ambiguous. In primary analyses of cross-sectional data among participants of the Study of Health in Pomerania (north-east Germany), women with low school education and low income were at highest risk for missing teeth, whereas being single was a risk indicator for missing teeth in men. Using the 5-year follow-up of this study, we aimed at verifying these findings and at investigating the gender-dependent impact of key socioeconomic indicators on tooth loss. METHODS: The longitudinal data originate from 1971 subjects (1062 women) aged 25-59 enrolled from 1997 to 2001 and again from 2002 to 2006. The effects of marital status, household income, school education and occupational prestige for tooth loss were examined by gender using negative binomial regression analyses. RESULTS: Low education and low income were moderately [relative risks (RR) between 1.6 and 2.0] associated with tooth loss among both women and men, whereas occupational prestige was not. After multiple imputations of missing data, less-educated women with lower income exhibited the highest risk of tooth loss [RR=3.1; 95% confidence interval (CI)=1.7-5.5 for <10 years of school education and the lowest income tertile] and tooth loss was more likely in single men (RR=1.5; 95% CI=1.0-2.2) than in single women (RR=0.9; 95% CI=0.6-1.3). CONCLUSIONS: The primary cross-sectional results were partly confirmed. Socioeconomic factors help to explain differences in tooth loss, although the causal pathways are speculative. To improve dental health, the policies should target not only the individual, e.g. oral health promotion, but also an entire population by better education and higher wage employment.

Socioeconomic indicators and prosthetic replacement of missing teeth in a working-age population--results of the Study of Health in Pomerania (SHIP).

OBJECTIVES: To analyse the possible effects of the socioeconomic status (SES) on the prosthetic replacement of missing teeth in working-age people and to explore the role of potential confounders. METHODS: Cross-sectional data were collected from 2310 German adults aged 30-59 years. The relationship between each of the three SES indicators (education, income, and occupational status) and dental prostheses were examined by multinomial logistic regression analyses. For that, partially dentate participants with suboptimal and no replacement of missing teeth were compared with partially dentate participants having optimal replacement. Potential confounders (age, sex, dental status, social network and social support) were entered if their inclusion in the model led to >or= 10% change in the coefficient of interest. RESULTS: Social network and social support did not meet the criterion for confounding. In the maxilla, having no replacement was positively associated with lower categories for each of the three SES indicators [Odds ratios (OR) between 1.6 and 2.1; 95% confidence intervals (CI) between 1.1 and 3.4]. Low occupational status was the single predictor for suboptimal dental prostheses (OR=3.2; 95% CI: 1.6-6.2). In the mandible, occupational status showed no association with the prosthetic status, whereas low educational level and low household income were determinants for having no replacement (OR=1.9 and 1.9, 95% CI: 1.0-3.5 and 1.1-3.0, respectively). Low household income was the single determinant for suboptimal replacement of missing teeth (OR=2.4, 95% CI=1.1-5.2). CONCLUSION: The findings may indicate the relevance of the financing of prosthodontic treatment. The strong association between various forms of upper dentures and occupational prestige can be seen as key contributing concept to how individuals' characteristics affect the outcome in prosthodontic care.

Association of mental distress with health care utilization and costs: a 5-year observation in a general population.

OBJECTIVE: Previous studies have associated mental distress and disorders with increased health care utilization and costs. However, most studies have selected subjects from treatment facilities or have applied retrospective designs. METHODS: N = 3,300 subjects from the baseline cohort of the Study of Health in Pomerania were followed up 5 years later. Mental distress was assessed with the SF-12 Health Survey and the Composite Diagnostic Screener for mental disorders. Two-part econometric models were applied adjusting for medical confounders and baseline services use. RESULTS: At 5-year follow-up somatization at baseline predicted an increase of inpatient (+39.9%) and outpatient costs (+11.9%). Depression predicted an increase of inpatient (+24.1%) and outpatient costs (+8.9%). Comorbidity of somatization and depression and somatization and anxiety predicted an increase in overall health care costs of > or =50%. CONCLUSION: Simple and time-efficient screening procedures for mental disorders may help to identify subjects at risk for increased future health care utilization. Standardized therapeutic interventions should be evaluated in subjects at risk in primary care.

[Mental distress and the use of psychiatric and psychotherapeutic treatments services: results of the Study of Health in Pomerania]. / Seelische Belastung und Inanspruchnahme psychiatrischer und psychotherapeutischer Versorgung--Ergebnisse der Study of Health in Pomerania (SHIP).

OBJECTIVE: Due to the lack of adequate data on the need of psychiatric and psychotherapeutic care in the community, an evidence-based goal directed development of treatment systems in socioeconomically poorer regions in former Eastern Germany is not feasible. METHOD: A community sample from the Study of Health in Pomerania (N = 4310) was investigated with the "Beschwerdenliste" from von Zerssen. The met and the unmet need of care were estimated. RESULTS: 3.1 % of all subjects were treated at least once by a mental health professional during the last 12 months. 12 % of the subjects, currently not in treatment, were estimated to be highly distressed by psychopathological symptoms and were considered to be potentially in need of mental health care. From this follows a treatment rate of 20 %. Subjects with high mental stress consulted their GP's, internists, orthopedics and neurologists significantly more often than subjects with low mental stress. CONCLUSION: A considerable need of psychiatric and psychotherapeutic treatment facilities has to be faced. Besides the improvement of psychiatric and psychotherapeutic treatment facilities, psychosocial networks should be established in order to provide an integrative and interdisciplinary approach to mental problems in the community.