Myocardial volume change during cardiac cycle derived from three orthogonal systolic strains: towards a quality assessment of strains.

BACKGROUND: The relative modification of the myocardial volume between end-systole and end-diastole ( Vs/d=Vend-systole/Vend-diastole ) has already been assessed with different methods and falls in a range of 0.9-0.97 (mean value = 0.93). PURPOSE: To estimate Vs/d from the three longitudinal ( ɛl) , circumferential ( ɛc ), and radial ( ɛr ) strains of the left ventricle using the formula: Vs/d=(1+ɛc)(1+ɛr)(1+ɛl) and to test whether this estimate of Vs/d can be used as a marker of the echocardiography quality. MATERIAL AND METHODS: Two hundred manuscripts, including a total of 34,690 patients or healthy volunteers, were identified in the Medline database containing values of ɛl , ɛc , and ɛr measured from echocardiography. RESULTS: The median value of was 0.93, in accordance with the literature, with no significant difference between patients or healthy volunteers ( P = 0.38). The proportion of studies with Vs/d=0.93±0.1 was 79%. When only considering groups of healthy volunteers, the studies failing this test had higher standard deviations for the three individual strains: 0.038 vs. 0.029 ( P = 0.02) for ɛl ; 0.060 vs. 0.034 ( P < 10-6) for ɛc , and 0.243 vs. 0.101 ( P < 10-14) for ɛr . CONCLUSION: The median ratio of the left ventricular myocardial volumes between end-systole and end-diastole in the investigated studies was Vs/d=0.93 . The formula (1+ɛc)(1+ɛr)(1+ɛl)∉[0.83;1.03] could be used to detect studies with inaccurate strain measurements.