RESUMO
The energy oriented mine ecological restoration mode of photovoltaic+ecological restoration provides a breakthrough for alleviating the dilemma of photovoltaic land development and solving the urgent need for restoration of abandoned mining land. Taking a mining area in central Liaoning Province as an example, we established three photovoltaic+mining ecological restoration modes, including forest-photovoltaic complementary, agriculture-photovoltaic, and grass photovoltaic complementation. Combined with the life cycle assessment method, we calculated and assessed the potential of photovoltaic+mining ecological restoration in carbon reduction and sink enhancement. The average annual carbon reduction and sink increase was 514.93 t CO2·hm-2 under the photovoltaic+mining ecological restoration mode, while the average annual carbon reduction per megawatt photovoltaic power station was 1242.94 t CO2. The adoption of photovoltaic+ecological restoration mode in this mining area could make carbon reduction and sink enhancement 6.30-7.79 Mt CO2 during 25 years. The carbon reduction and sink increment mainly stemmed from the photovoltaic clean power generation induced carbon reduction, accounting for 96.4%-99.4%, while the contribution of ecosystem carbon sink increment was small, accounting for only 0.6%-3.7% of the total. Among different photovoltaic+ecological restoration modes, the carbon reduction and sink increment was the largest in forest-photovoltaic complementary (7.11 Mt CO2), followed by agriculture-photovoltaic (7.04 Mt CO2), and the least in grass photovoltaic complementation (6.98 Mt CO2). Constructing the development mode of "photovoltaic+mining ecological restoration" could effectively leverage the dual benefits of reducing emissions from photovoltaic power generation and increase sinks from mining ecological restoration, which would be helpful for achieving the goal of carbon neutrality in China.
Assuntos
Sequestro de Carbono , Ecossistema , Mineração , China , Recuperação e Remediação Ambiental/métodos , Modelos Teóricos , Carbono/química , Carbono/análise , Conservação dos Recursos Naturais/métodos , Dióxido de Carbono/análise , Energia SolarRESUMO
Currently,the research or publications related to the clinical comprehensive evaluation of Chinese patent medicine are increasing,which attracts the broad attention of all circles. According to the completed clinical evaluation report on Chinese patent medicine,there are still practical problems and technical difficulties such as unclear responsibility of the evaluation organization,unclear evaluation subject,miscellaneous evaluation objects,and incomplete and nonstandard evaluation process. In terms of evaluation standards and specifications,there are different types of specifications or guidelines with different emphases issued by different academic groups or relevant institutions. The professional guideline is required to guide the standardized and efficient clinical comprehensive evaluation of Chinese patent medicine and further improve the authority and quality of evaluation. In combination with the characteristics of Chinese patent medicine and the latest research achievement at home and abroad,the detailed specifications were formulated from six aspects including design,theme selection,content and index,outcome,application and appraisal,and quality control. The guideline was developed based on the guideline development requirements of China Assoication of Chinese medicine. After several rounds of expert consensus and public consultation,the current version of the guideline has been developed.
Assuntos
Medicamentos de Ervas Chinesas , Medicina Tradicional Chinesa , Medicamentos sem Prescrição , Consenso , China , Padrões de ReferênciaRESUMO
Arsenic (As)-contaminated soils occur widely worldwide. In the present study, three low-cost Fe/Al-based materials, including red soil (RS), sponge iron filter (SIF) and Al-based water treatment sludge (WTS), were applied as amendments to remediate As-contaminated soils under anoxic conditions. After 180 d of incubation, the proportion of the sum of nonspecifically absorbed As (F1) and specifically absorbed As (F2) to the total As was reduced by 6%, 52% and 13% with 5% of RS, SIF and WTS addition, respectively, compared to the control soil (31%). The results showed that among the three amendments, SIF was the most effective at decreasing As bioaccessibility in soils. Compared with RS and WTS, SIF intensified the decrease of labile fractions and the increase of unlabile fractions, and the redistribution of the amorphous oxide-bound fraction (F3) and crystalline hydrous oxide-bound fraction (F4) occurred in the SIF-amended soil. Moreover, the As stabilization processes were divided into two stages in the control and RS-amended soil, while the processes were divided into three stages in both SIF- and WTS-treated soil. The As stabilization processes in all treated soils were characterized by the transformation of labile fractions into more immobilizable fractions, except for F4 transforming into F3 in the first stage in SIF-amended soil. Correspondingly, inner-surface complexation and occlusion within Fe/Al hydroxides were the common driving mechanisms for the transformation of As fractions. Therefore, taking into consideration the results of this study, SIF could be a more promising alternative than the other two materials to passivate As in anoxic soils.
Assuntos
Alumínio/química , Arsênio/análise , Ferro/química , Poluentes do Solo/análise , Solo/químicaRESUMO
Objectives: The discovery of mobile colistin resistance mcr-1, a plasmid-borne polymyxin resistance gene, highlights the potential for widespread resistance to the last-line polymyxins. In the present study, we investigated the impact of mcr-1 acquisition on polymyxin resistance and biological fitness in Klebsiella pneumoniae. Methods: K. pneumoniae B5055 was used as the parental strain for the construction of strains carrying vector only (pBBR1MCS-5) and mcr-1 recombinant plasmids (pmcr-1). Plasmid stability was determined by serial passaging for 10 consecutive days in antibiotic-free LB broth, followed by patching on gentamicin-containing and antibiotic-free LB agar plates. Lipid A was analysed using LC-MS. The biological fitness was examined using an in vitro competition assay analysed with flow cytometry. The in vivo fitness cost of mcr-1 was evaluated in a neutropenic mouse thigh infection model. Results: Increased polymyxin resistance was observed following acquisition of mcr-1 in K. pneumoniae B5055. The modification of lipid A with phosphoethanolamine following mcr-1 addition was demonstrated by lipid A profiling. The plasmid stability assay revealed the instability of the plasmid after acquiring mcr-1. Reduced in vitro biological fitness and in vivo growth were observed with the mcr-1-carrying K. pneumoniae strain. Conclusions: Although mcr-1 confers a moderate level of polymyxin resistance, it is associated with a significant biological fitness cost in K. pneumoniae. This indicates that mcr-1-mediated resistance in K. pneumoniae could be attenuated by limiting the usage of polymyxins.
Assuntos
Antibacterianos/farmacologia , Farmacorresistência Bacteriana/genética , Aptidão Genética , Klebsiella pneumoniae/efeitos dos fármacos , Klebsiella pneumoniae/genética , Polimixinas/farmacologia , Animais , Proteínas de Bactérias/genética , Colistina/farmacologia , Feminino , Camundongos , Testes de Sensibilidade Microbiana , Neutropenia/induzido quimicamente , Plasmídeos/efeitos dos fármacos , Plasmídeos/genéticaRESUMO
In order to illustrate heavy metal ecotoxicology associated with interactions between chemicals and biological systems, we investigated physiological changes (metabolism and behavior response) of zebra fish (Danio rerio) under 48 h Cadmium chloride (CdCl2) exposure using online monitoring technique. The concentrations of CdCl2 were designed as 4.26, 42.6 and 85.2 mg/L, which were 0.1, 1.0, and 2.0 based on toxic unit (TU), respectively. The metabolism was assessed using the oxygen consumption (OC), and the behavior response was analyzed in behavior strength (BS). Significant inhibition of both OC and BS could be observed: OC was 617.39 ± 30.48 mg/kg/h in the control, and it decreased rapidly to 229.07 ± 28.66 mg/kg/h in 2.0 TU treatment. BS changed from 0.76 ± 0.07 (control) to 0.39 ± 0.04 (2.0 TU) with the increase of exposure concentrations. Further results suggested that both factors were related to diurnal variation during 48 h exposure, which could be regarded as circadian rhythms: the average values of OC and BS during photo-phase were significantly higher than both during scoto-phase in CdCl2 treatments (p < 0.05). After integrated analysis, the original values of both OC and BS with wide fluctuation showed a negative linear relationship with CdCl2 concentration. The levels of both OC and BS were positively correlated with CdCl2 (r = 0.93 and p < 0.01). It is suggested that both OC and BS provide an objective ground for CdCl2 stress assessment, and that also could be applied to test the changes of organisms quantitatively in toxic physiology.
Assuntos
Cádmio/toxicidade , Estresse Fisiológico/fisiologia , Poluentes Químicos da Água/toxicidade , Peixe-Zebra/fisiologia , Animais , Cádmio/metabolismo , Peixe-Zebra/metabolismoRESUMO
OBJECTIVE: To provide basis for selecting the suitable method of Down's syndrome biochemical screening in the second trimester pregnancy. METHODS: A total of 30 547 singleton pregnancies between 14 and 20(+ 6) weeks of pregnancy were collected and analyzed for maternal serum alpha-fetoproteins (AFP) and human chorionic gonadotrophin, free beta subunit (beta-HCG) with or without unconjugated estriol (uE3). The screening risks were calculated using the software Lifecycle. The detection rates and the cost of per Down's syndrome detected were calculated and compared. And four different methods were compared in a series of 64 serum samples from Down's syndrome pregnancies. RESULTS: (1) Among the 64 affected cases, the detection rate of Down's syndrome was improved no matter in the double test (DT) or in the triple test (TT) if software Lifecycle (LC) was used to evaluate risks. And it was not suitable to evaluate risks with software 2T-Risks in the triple tests. (2) In the cohort of 30 547 singleton pregnancies, the detection rate of Down's syndrome with project DT-LC, which was double test using AFP and free beta-HCG together with software Lifecycle, and project TT-LC, which was triple test using AFP, free beta-HCG and uE3 together with software Lifecycle, was 56.25% and 57.14%, respectively. The former project was better because it decreased the false positive rate at a lower running cost. CONCLUSION: The DT-LC is an effective screening strategy for second trimester detection of fetal Down's syndrome in mainland China.
Assuntos
Síndrome de Down/sangue , Síndrome de Down/diagnóstico , Segundo Trimestre da Gravidez/sangue , Diagnóstico Pré-Natal/métodos , Adulto , Gonadotropina Coriônica Humana Subunidade beta/sangue , Estriol/sangue , Feminino , Testes Genéticos/métodos , Humanos , Gravidez , Diagnóstico Pré-Natal/economia , Adulto Jovem , alfa-Fetoproteínas/metabolismoRESUMO
The temporal distribution of polycyclic aromatic hydrocarbons (PAHs) was measured in sediment core from Miyun reservoir, and the possible sources and the potential risk assessment also have been identified. The aim of the present work is to understand the temporal trend of PAHs in Miyun reservoir recently. The concentrations of sigma PAH16 in sediment ranged from 618.5 ng/g to 1087.9 ng/g, and roughly, increased continuously from the bottom (16 cm under the surface) to the surface sediment. The PAHs in sediment core were mainly composed of phenanthrene and fluorene. The concentrations of phenanthrene and fluorene in sediment core were 236.1-417.9 ng/g and 91-130.8 ng/g, respectively. Both of them accounted for 47.2%-58.1% of the sigma PAH16 in sediments. Nevertheless, high-rings aromatic hydrocarbons (5-6 rings) were increased steadily in recent years. PAHs compositional profile indicated that the main source of PAHs was originated from the combustion of coal and biomass. However, the vertical profiles of Flu/Flu + Pyr and INP/INP + BghiP ratios suggested that the vehicles emission was increased very recently. Risk assessment suggested that PAHs in sediment from Miyun reservoir was no significant biological impairment, and low toxicological risk of PAHs was found up to now.
Assuntos
Monitoramento Ambiental/métodos , Sedimentos Geológicos/análise , Hidrocarbonetos Policíclicos Aromáticos/análise , Poluentes Químicos da Água/análise , Abastecimento de Água/análise , China , Fluorenos/análise , Fenantrenos/análise , Medição de Risco , Fatores de Tempo , Poluentes Químicos da Água/químicaRESUMO
OBJECTIVE: The purpose of this study was to evaluate the capability of real-time triplane echocardiography (RT3PE) for monitoring global and regional systolic function of the left ventricle (LV) after surgical revascularization and for evaluating the effect of surgery and predicting restenosis. METHODS: Forty-nine patients underwent RT3PE before and at 10 days and 1, 3, and 6 months after coronary artery bypass grafting (CABG). The global systolic function of the LV was assessed with the parameters of end-diastolic volume (EDV), end-systolic volume (ESV), ejection fraction (EF), and stroke volume (SV). The regional myocardial deformation was detected by triplane strain rate imaging. Recovery of myocardial function after surgery and the correlation between global and regional function were investigated. RESULTS: In 41 of the 49 patients, the EDV and ESV decreased, and the EF and SV increased gradually and showed statistical significance at 3 and 6 months after surgery (P < .05; P < .01). The systolic strain rate (SR(sys)) and systolic strain (S(sys)) increased, and the postsystolic strain index (PSI) decreased progressively after CABG, with significant changes in almost all studied segments at 6 months (P < .05; P < .01). In addition, recovery of the SR(sys), S(sys), and PSI at each follow-up stage after surgery correlated well with EF improvement, with a positive correlation between the SR(sys), S(sys), and EF and a negative correlation between the PSI and EF. Restenosis was suspected in the other 8 patients. The sensitivity, specificity, and accuracy of RT3PE to predict restenosis were 75.00%, 89.47%, and 85.19%, respectively. CONCLUSIONS: Real-time triplane echocardiography can be used to quantitatively assess global and regional myocardial function. It may represent a new, powerful method to monitor improvement of myocardial function after CABG and to predict restenosis.