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Am J Surg ; 206(1): 8-15, 2013 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-23706259

RESUMO

BACKGROUND: Antibiotic prophylaxis is frequently administered after liver resection to prevent postoperative infections. However, very few studies have examined the usefulness of antibiotic prophylaxis after liver resection. A randomized controlled trial was conducted to evaluate the postoperative antibiotic prophylaxis in patients after liver resection. METHODS: A total of 241 patients scheduled to undergo liver resection were randomly assigned to the non-postoperative antibiotic group (n = 95) or the antibiotic group (n = 95). The antibiotic group was given flomoxef sodium every 12 hours for 3 days after the operation. The end point was signs of infection, surgical site infection, or infectious complications. RESULTS: There were no significant differences between the 2 groups in signs of infection (21.3% vs 25.5%, P = .606), the incidence of systemic inflammatory response syndrome (11.7% vs 17.0%, P = .406), infectious complications (7.5% vs 17.0%, P = .073), surgical site infection (10.6% vs 13.8%, P = .657), and remote site infection (2.1% vs 8.5%, P = .100). CONCLUSIONS: Postoperative antibiotic prophylaxis cannot prevent postoperative infections after liver resection, and it is thought that antibiotic prophylaxis is unnecessary and costly.


Assuntos
Antibacterianos/uso terapêutico , Antibioticoprofilaxia , Cefalosporinas/uso terapêutico , Hepatectomia/efeitos adversos , Infecções/etiologia , Neoplasias Hepáticas/cirurgia , Adulto , Idoso , Idoso de 80 Anos ou mais , Antibioticoprofilaxia/economia , Antibioticoprofilaxia/métodos , Biomarcadores/sangue , Carcinoma Hepatocelular/cirurgia , Colangiocarcinoma/cirurgia , Feminino , Hepatectomia/métodos , Humanos , Infecções/microbiologia , Neoplasias Hepáticas/metabolismo , Neoplasias Hepáticas/secundário , Transplante de Fígado/efeitos adversos , Masculino , Pessoa de Meia-Idade , Infecção da Ferida Cirúrgica/etiologia , Infecção da Ferida Cirúrgica/microbiologia , Infecção da Ferida Cirúrgica/prevenção & controle , Síndrome de Resposta Inflamatória Sistêmica/etiologia , Síndrome de Resposta Inflamatória Sistêmica/prevenção & controle , Falha de Tratamento
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