Leptin and energy balance: exploring Leptin's role in the regulation of energy intake and energy expenditure.

Leptin is a tonic appetite-regulating hormone, which is integral for the long-term regulation of energy balance. The current evidence suggests that the typical orexigenic or anorexigenic response of many of these appetite-regulating hormones, most notably ghrelin and cholecystokinin (CCK), require leptin to function whereas glucagon-like peptide-1 (GLP-1) is required for leptin to function, and these responses are altered when leptin injection or gene therapy is administered in combination with these same hormones or respective agonists. The appetite-regulatory pathway is complex, thus peptide tyrosine tyrosine (PYY), brain-derived neurotrophic factor (BDNF), orexin-A (OXA), and amylin also maintain ties to leptin, however these are less well understood. While reviews to date have focused on the existing relationships between leptin and the various neuropeptide modulators of appetite within the central nervous system (CNS) or it's role in thermogenesis, no review paper has synthesised the information regarding the interactions between appetite-regulating hormones and how leptin as a chronic regulator of energy balance can influence the acute appetite-regulatory response. Current evidence suggests that potential relationships exist between leptin and the circulating peripheral appetite hormones ghrelin, GLP-1, CCK, OXA and amylin to exhibit either synergistic or opposing effects on appetite inhibition. Though more research is warranted, leptin appears to be integral in both energy intake and energy expenditure. More specifically, functional leptin receptors appear to play an essential role in these processes.

Assessment of pedometer accuracy in capturing habitual types of physical activities in overweight and obese children.

BACKGROUND: Currently, there is a limited amount of research exploring physical activity measurement tools in overweight and obese (OW/OB) children using pedometers. Thus, our objective was to determine the accuracy of one spring-levered (SC-T2) and two piezoelectric pedometers (NL-1000 and Piezo) in OW/OB children. METHODS: A total of 26 boys and 34 girls (n = 60) participated. Pedometer step-counts were compared to observed step counts for walking (walking, stair ascent and decent) and hopping tests. Pedometer accuracies were compared with Friedman tests while Bland-Altman plots were used to establish the accuracy of each pedometer against direct observations. RESULTS: Boys (n = 26) and females (n = 34) were 96 and 91% OB, respectively. The two piezoelectric pedometers (NL-1000 and Piezo) were accurate for walking and stair climbing tasks, however all pedometers were inaccurate for hopping tests. Averaged over all three walking activities, the NL-1000 was the most accurate with 6.7% median error (interquartile range (IQR): 0.0-13.3); followed by the Piezo with 10.0% median error (IQR: 3.3-18.1); SC-T2 was the least accurate with -14.7% median error (IQR: -54.8-3.5). CONCLUSION: These results support the use of the piezoelectric pedometers for walking and stair climbing types of activities, which are typical for OW/OB children in a nonlaboratory setting.