RESUMO
We have developed recombinant fragment C based rapid point of care dipstick devices to assess tetanus immunization status using plasma or whole blood. The devices demonstrated specificity of 0.90 and sensitivity of 0.90 (whole blood)/0.94 (plasma) at field sites in Bangladesh and The Gambia when compared to a commercial ELISA with the immune cut-off titer set as ≥0.1IU/mL.
Assuntos
Anticorpos Antibacterianos/sangue , Fragmentos de Peptídeos/imunologia , Proteínas Recombinantes/imunologia , Toxina Tetânica/imunologia , Toxoide Tetânico/imunologia , Tétano/imunologia , Adulto , Bangladesh , Criança , Gâmbia , Humanos , Masculino , Fragmentos de Peptídeos/genética , Proteínas Recombinantes/genética , Sensibilidade e Especificidade , Toxina Tetânica/genética , VacinaçãoRESUMO
The African Society of Human Genetics (AfSHG), founded in 2003 with its inaugural meeting in Accra, Ghana,1 has the stated missions of (1) disseminating information about human genetics research in Africa, (2) establishing a mentorship network providing educational resources, including the development of appropriate technology transfer, (3) providing advocacy for human genetic research in Africa, and (4) encouraging collaborative research. Despite its young age, the AfSHG has developed a strong cadre of active researchers, both within and outside of Africa, with more than 400 members (from 16 countries across Africa as well as 8 other countries), and has held six successful meetings, five in Africa and one in the United States.
